鹿子木将夫　KAKOKI MASAO　カコキ マサオ

研究者情報

研究者情報

• 氏名

  鹿子木将夫, カコキ マサオ

所属

• 生理学(壬生), 准教授

研究業績

受賞

• 2023年05月15日, 獨協医学会, 第50回獨協医学会学術集会一般演題最優秀賞, 形質転換成長因子β1低発現マウスにおける大動脈瘤の発症機序, 鹿子木將夫, 発表者, 国内学会・会議・シンポジウム等の賞

論文

原著論文
• A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling., Soomro Asfia;Khajehei Mohammad;Li Renzhong;O'Neil Kian;Zhang Dan;Gao Bo;MacDonald Melissa;Kakoki Masao;Krepinsky Joan C, Cellular & molecular biology letters, 28（1）, 10, 2023年01月30日

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• シアノコバラミンはI型糖尿病において酸化ストレスとDNMT-SOCS1/3-IGF-1シグナルの修飾によって心筋症を予防する, 4（1）, 775-775, 2021年06月23日

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• Kinin B1 Receptor Is Important in the Pathogenesis of Myeloperoxidase-Specific ANCA GN., Hu Peiqi;Su Hua;Xiao Hong;Gou Shen-Ju;Herrera Carolina A;Alba Marco A;Kakoki Masao;Falk Ronald J;Jennette J Charles, Journal of the American Society of Nephrology : JASN, 31（2）, 297-307, 2019年11月26日

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• Engulfment and cell motility protein 1 potentiates diabetic cardiomyopathy via Rac-dependent and Rac-independent ROS production., Kakoki Masao;Bahnson Edward M;Hagaman John R;Siletzky Robin M;Grant Ruriko;Kayashima Yukako;Li Feng;Lee Esther Y;Sun Michelle T;Taylor Joan M;Rice Jessica C;Almeida Michael F;Bahr Ben A;Jennette J Charles;Smithies Oliver;Maeda-Smithies Nobuyo, JCI insight, 4（12）, 2019年06月20日

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• Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice., Li Feng;Kakoki Masao;Smid Marcela;Boggess Kim;Wilder Jennifer;Hiller Sylvia;Bounajim Carol;Parnell Scott E;Sulik Kathleen K;Smithies Oliver;Maeda-Smithies Nobuyo, Hypertension (Dallas, Tex. : 1979), 71（5）, 894-903, 2018年04月02日

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• GRAF3 serves as a blood volume-sensitive rheostat to control smooth muscle contractility and blood pressure., Bai Xue;Mangum Kevin;Kakoki Masao;Smithies Oliver;Mack Christopher P;Taylor Joan M, Small GTPases, 11（3）, 194-203, 2018年01月07日

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• Prolactin alters blood pressure by modulating the activity of endothelial nitric oxide synthase., Chang Albert S;Grant Ruriko;Tomita Hirofumi;Kim Hyung-Suk;Smithies Oliver;Kakoki Masao, Proceedings of the National Academy of Sciences of the United States of America, 113（44）, 12538-12543, 2016年10月17日

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• Effects of tetrahydrobiopterin on endothelial dysfunction in rats with ischemic acute renal failure., Kakoki Masao;Hirata Yasunobu;Hayakawa Hiroshi;Suzuki Etsu;Nagata Daisuke;Tojo Akihiro;Nishimatsu Hiroaki;Nakanishi Nobuo;Hattori Yoshiyuki;Kikuchi Kazuya;Nagano Tetsuo;Omata Masao, Journal of the American Society of Nephrology : JASN, 11（2）, 301-309, 2000年02月

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• Cationic amino acid transport in the renal medulla and blood pressure regulation., Kakoki Masao;Wang Weili;Mattson David L, Hypertension (Dallas, Tex. : 1979), 39（2）, 287-292, 2002年02月

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• Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury: studies on transgenic/knockout mice of adrenomedullin gene., Nishimatsu Hiroaki;Hirata Yasunobu;Shindo Takayuki;Kurihara Hiroki;Kakoki Masao;Nagata Daisuke;Hayakawa Hiroshi;Satonaka Hiroshi;Sata Masataka;Tojo Akihiro;Suzuki Etsu;Kangawa Kenji;Matsuo Hisayuki;Kitamura Tadaichi;Nagai Ryozo, Circulation research, 90（6）, 657-663, 2002年04月05日

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• Endothelial responses of the aorta from adrenomedullin transgenic mice and knockout mice., Nishimatsu Hiroaki;Hirata Yasunobu;Shindo Takayuki;Kurihara Hiroki;Suzuki Etsu;Sata Masataka;Satonaka Hiroshi;Takeda Ryo;Nagata Daisuke;Kakoki Masao;Hayakawa Hiroshi;Kangawa Kenji;Matsuo Hisayuki;Kitamura Tadaichi;Nagai Ryozo, Hypertension research : official journal of the Japanese Society of Hypertension, 26 Suppl, S79-S84, 2003年02月

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• Altering the expression in mice of genes by modifying their 3' regions., Kakoki Masao;Tsai Yau-Sheng;Kim Hyung-Suk;Hatada Seigo;Ciavatta Dominic J;Takahashi Nobuyuki;Arnold Larry W;Maeda Nobuyo;Smithies Oliver, Developmental cell, 6（4）, 597-606, 2004年04月

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• L-Arginine uptake affects nitric oxide production and blood flow in the renal medulla., Kakoki Masao;Kim Hyung-Suk;Arendshorst William J;Mattson David L, American journal of physiology. Regulatory, integrative and comparative physiology, 287（6）, R1478-R1485, 2004年08月19日

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• Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor., Kakoki Masao;Takahashi Nobuyuki;Jennette J Charles;Smithies Oliver, Proceedings of the National Academy of Sciences of the United States of America, 101（36）, 13302-13305, 2004年08月23日

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• Amino acids as modulators of endothelium-derived nitric oxide., Kakoki Masao;Kim Hyung-Suk;Edgell Cora-Jean S;Maeda Nobuyo;Smithies Oliver;Mattson David L, American journal of physiology. Renal physiology, 291（2）, F297-F304, 2006年03月28日

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• Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors., Kakoki Masao;Kizer Catherine M;Yi Xianwen;Takahashi Nobuyuki;Kim Hyung-Suk;Bagnell C Robert;Edgell Cora-Jean S;Maeda Nobuyo;Jennette J Charles;Smithies Oliver, The Journal of clinical investigation, 116（5）, 1302-1309, 2006年04月06日

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• Quantitative effects of common genetic variations in the 3'UTR of the human LDL-receptor gene and their associations with plasma lipid levels in the Atherosclerosis Risk in Communities study., Muallem Hind;North Kari E;Kakoki Masao;Wojczynski Mary K;Li Xia;Grove Megan;Boerwinkle Eric;Wilhelmsen Kirk C;Heiss Gerardo;Maeda Nobuyo, Human genetics, 121（3-4）, 421-431, 2007年02月02日

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• Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury., Kakoki Masao;McGarrah Robert W;Kim Hyung-Suk;Smithies Oliver, Proceedings of the National Academy of Sciences of the United States of America, 104（18）, 7576-7581, 2007年04月23日

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• Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice., Kakoki Masao;Sullivan Kelli A;Backus Carey;Hayes John M;Oh Sang Su;Hua Kunjie;Gasim Adil M H;Tomita Hirofumi;Grant Ruriko;Nossov Sarah B;Kim Hyung-Suk;Jennette J Charles;Feldman Eva L;Smithies Oliver, Proceedings of the National Academy of Sciences of the United States of America, 107（22）, 10190-10195, 2010年05月17日

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• Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice., Wende Adam R;Soto Jamie;Olsen Curtis D;Pires Karla M P;Schell John C;Larrieu-Lahargue Frederic;Litwin Sheldon E;Kakoki Masao;Takahashi Nobuyuki;Smithies Oliver;Abel E Dale, Endocrinology, 151（8）, 3536-3542, 2010年05月25日

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• Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney., Vashistha Himanshu;Singhal Pravin C;Malhotra Ashwani;Husain Mohammad;Mathieson Peter;Saleem Moin A;Kuriakose Cyril;Seshan Surya;Wilk Anna;Delvalle Luis;Peruzzi Francesca;Giorgio Marco;Pelicci Pier Giuseppe;Smithies Oliver;Kim Hyung-Suk;Kakoki Masao;Reiss Krzysztof;Meggs Leonard G, American journal of physiology. Renal physiology, 303（12）, F1629-F1640, 2012年09月26日

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• Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1., Kakoki Masao;Pochynyuk Oleh M;Hathaway Catherine M;Tomita Hirofumi;Hagaman John R;Kim Hyung-Suk;Zaika Oleg L;Mamenko Mykola;Kayashima Yukako;Matsuki Kota;Hiller Sylvia;Li Feng;Xu Longquan;Grant Ruriko;Bertorello Alejandro M;Smithies Oliver, Proceedings of the National Academy of Sciences of the United States of America, 110（14）, 5600-5605, 2013年03月15日

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• The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension., Bai Xue;Lenhart Kaitlin C;Bird Kim E;Suen Alisa A;Rojas Mauricio;Kakoki Masao;Li Feng;Smithies Oliver;Mack Christopher P;Taylor Joan M, Nature communications, 4, 2910, 2013年

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• Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade., Hathaway Catherine K;Grant Ruriko;Hagaman John R;Hiller Sylvia;Li Feng;Xu Longquan;Chang Albert S;Madden Victoria J;Bagnell C Robert;Rojas Mauricio;Kim Hyung-Suk;Wu Bingruo;Zhou Bin;Smithies Oliver;Kakoki Masao, Proceedings of the National Academy of Sciences of the United States of America, 112（16）, 5141-5146, 2015年04月06日

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• Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice., Hathaway Catherine K;Gasim Adil M H;Grant Ruriko;Chang Albert S;Kim Hyung-Suk;Madden Victoria J;Bagnell C Robert;Jennette J Charles;Smithies Oliver;Kakoki Masao, Proceedings of the National Academy of Sciences of the United States of America, 112（18）, 5815-5820, 2015年04月20日

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• High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy., Hathaway Catherine K;Chang Albert S;Grant Ruriko;Kim Hyung-Suk;Madden Victoria J;Bagnell C Robert;Jennette J Charles;Smithies Oliver;Kakoki Masao, Proceedings of the National Academy of Sciences of the United States of America, 113（8）, 2218-2222, 2016年02月08日

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総説論文
• The kallikrein-kinin system in health and in diseases of the kidney., Kakoki Masao;Smithies Oliver, Kidney international, 75（10）, 1019-1030, 2009年02月04日

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• Mouse models of diabetic nephropathy., Brosius Frank C;Alpers Charles E;Bottinger Erwin P;Breyer Matthew D;Coffman Thomas M;Gurley Susan B;Harris Raymond C;Kakoki Masao;Kretzler Matthias;Leiter Edward H;Levi Moshe;McIndoe Richard A;Sharma Kumar;Smithies Oliver;Susztak Katalin;Takahashi Nobuyuki;Takahashi Takamune; , Journal of the American Society of Nephrology : JASN, 20（12）, 2503-2512, 2009年09月03日

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• The kallikrein-kinin system and oxidative stress., Kayashima Yukako;Smithies Oliver;Kakoki Masao, Current opinion in nephrology and hypertension, 21（1）, 92-96, 2012年01月

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• The kallikrein-kinin system in diabetic nephropathy., Tomita Hirofumi;Sanford Ryan B;Smithies Oliver;Kakoki Masao, Kidney international, 81（8）, 733-744, 2012年02月08日

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• Transforming growth factor beta1 and aldosterone., Matsuki Kota;Hathaway Catherine K;Chang Albert S;Smithies Oliver;Kakoki Masao, Current opinion in nephrology and hypertension, 24（2）, 139-144, 2015年03月

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• The role of transforming growth factor β1 in the regulation of blood pressure., Matsuki Kota;Hathaway Catherine K;Lawrence Marlon G;Smithies Oliver;Kakoki Masao, Current hypertension reviews, 10（4）, 223-238, 2014年

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• Transforming growth factor-β1 and diabetic nephropathy., Chang Albert S;Hathaway Catherine K;Smithies Oliver;Kakoki Masao, American journal of physiology. Renal physiology, 310（8）, F689-F696, 2015年12月30日

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講演・口頭発表等

• 局所と循環血中の形質転換成長因子β1が、Tgfb1L/Lマウスにおける大動脈瘤に与える影響の相違, 鹿子木將夫, 第100回日本生理学会大会, 2023年03月15日, 2023年03月14日, 2023年03月16日, ポスター発表
• 形質転換成長因子β1低発言マウスにおける大動脈瘤の発症機序, 鹿子木將夫, 第50回獨協医学会学術集会, 2023年12月03日, 2023年12月03日, 2024年01月29日, 口頭発表（一般）
• 3’非翻訳領域(3'UTR)の置換による遺伝子滴定マウスの作成, 鹿子木將夫, 第252回日本生理学会東京談話会, 2023年10月22日, 2023年10月22日, 2023年10月22日, 口頭発表（招待・特別）

学内助成金

• 形質転換成長因子β関連シグナルを標的とするうつ病の内科的治療法の探索, 2023年04月01日, 2024年03月31日, 1000000

委託研究費

• Loeys-Dietz症候群のマウスモデルにおける大動脈瘤の内科的治療法の探索, 2023年04月01日, 2024年03月31日, 2000000