KAKOKI MASAO

Profiles

Profiles

• 氏名

  KAKOKI MASAO

Affiliation

• Department of Physiology, Associate Professor

Research achievements

Awards

• 15 May 2023, Author, Japan society

Published Papers

Original paper
• A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling., Soomro Asfia;Khajehei Mohammad;Li Renzhong;O'Neil Kian;Zhang Dan;Gao Bo;MacDonald Melissa;Kakoki Masao;Krepinsky Joan C, Cellular & molecular biology letters, 28(1), 10, 30 Jan. 2023

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• Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling, Kakoki M, Ramanathan PV, Hagaman JR, Grant R, Wilder JC, Taylor JM, Charles Jennette J, Smithies O, Maeda-Smithies N, Communications Biology, 4(1), 775-775, 23 Jun. 2021

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• Kinin B1 Receptor Is Important in the Pathogenesis of Myeloperoxidase-Specific ANCA GN., Hu Peiqi;Su Hua;Xiao Hong;Gou Shen-Ju;Herrera Carolina A;Alba Marco A;Kakoki Masao;Falk Ronald J;Jennette J Charles, Journal of the American Society of Nephrology : JASN, 31(2), 297-307, 26 Nov. 2019

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• Engulfment and cell motility protein 1 potentiates diabetic cardiomyopathy via Rac-dependent and Rac-independent ROS production., Kakoki Masao;Bahnson Edward M;Hagaman John R;Siletzky Robin M;Grant Ruriko;Kayashima Yukako;Li Feng;Lee Esther Y;Sun Michelle T;Taylor Joan M;Rice Jessica C;Almeida Michael F;Bahr Ben A;Jennette J Charles;Smithies Oliver;Maeda-Smithies Nobuyo, JCI insight, 4(12), 20 Jun. 2019

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• Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice., Li Feng;Kakoki Masao;Smid Marcela;Boggess Kim;Wilder Jennifer;Hiller Sylvia;Bounajim Carol;Parnell Scott E;Sulik Kathleen K;Smithies Oliver;Maeda-Smithies Nobuyo, Hypertension (Dallas, Tex. : 1979), 71(5), 894-903, 02 Apr. 2018

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• GRAF3 serves as a blood volume-sensitive rheostat to control smooth muscle contractility and blood pressure., Bai Xue;Mangum Kevin;Kakoki Masao;Smithies Oliver;Mack Christopher P;Taylor Joan M, Small GTPases, 11(3), 194-203, 07 Jan. 2018

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• Prolactin alters blood pressure by modulating the activity of endothelial nitric oxide synthase., Chang Albert S;Grant Ruriko;Tomita Hirofumi;Kim Hyung-Suk;Smithies Oliver;Kakoki Masao, Proceedings of the National Academy of Sciences of the United States of America, 113(44), 12538-12543, 17 Oct. 2016

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• Effects of tetrahydrobiopterin on endothelial dysfunction in rats with ischemic acute renal failure., Kakoki Masao;Hirata Yasunobu;Hayakawa Hiroshi;Suzuki Etsu;Nagata Daisuke;Tojo Akihiro;Nishimatsu Hiroaki;Nakanishi Nobuo;Hattori Yoshiyuki;Kikuchi Kazuya;Nagano Tetsuo;Omata Masao, Journal of the American Society of Nephrology : JASN, 11(2), 301-309, Feb. 2000

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• Cationic amino acid transport in the renal medulla and blood pressure regulation., Kakoki Masao;Wang Weili;Mattson David L, Hypertension (Dallas, Tex. : 1979), 39(2), 287-292, Feb. 2002

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• Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury: studies on transgenic/knockout mice of adrenomedullin gene., Nishimatsu Hiroaki;Hirata Yasunobu;Shindo Takayuki;Kurihara Hiroki;Kakoki Masao;Nagata Daisuke;Hayakawa Hiroshi;Satonaka Hiroshi;Sata Masataka;Tojo Akihiro;Suzuki Etsu;Kangawa Kenji;Matsuo Hisayuki;Kitamura Tadaichi;Nagai Ryozo, Circulation research, 90(6), 657-663, 05 Apr. 2002

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• Endothelial responses of the aorta from adrenomedullin transgenic mice and knockout mice., Nishimatsu Hiroaki;Hirata Yasunobu;Shindo Takayuki;Kurihara Hiroki;Suzuki Etsu;Sata Masataka;Satonaka Hiroshi;Takeda Ryo;Nagata Daisuke;Kakoki Masao;Hayakawa Hiroshi;Kangawa Kenji;Matsuo Hisayuki;Kitamura Tadaichi;Nagai Ryozo, Hypertension research : official journal of the Japanese Society of Hypertension, 26 Suppl, S79-S84, Feb. 2003

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• Altering the expression in mice of genes by modifying their 3' regions., Kakoki Masao;Tsai Yau-Sheng;Kim Hyung-Suk;Hatada Seigo;Ciavatta Dominic J;Takahashi Nobuyuki;Arnold Larry W;Maeda Nobuyo;Smithies Oliver, Developmental cell, 6(4), 597-606, Apr. 2004

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• L-Arginine uptake affects nitric oxide production and blood flow in the renal medulla., Kakoki Masao;Kim Hyung-Suk;Arendshorst William J;Mattson David L, American journal of physiology. Regulatory, integrative and comparative physiology, 287(6), R1478-R1485, 19 Aug. 2004

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• Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor., Kakoki Masao;Takahashi Nobuyuki;Jennette J Charles;Smithies Oliver, Proceedings of the National Academy of Sciences of the United States of America, 101(36), 13302-13305, 23 Aug. 2004

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• Amino acids as modulators of endothelium-derived nitric oxide., Kakoki Masao;Kim Hyung-Suk;Edgell Cora-Jean S;Maeda Nobuyo;Smithies Oliver;Mattson David L, American journal of physiology. Renal physiology, 291(2), F297-F304, 28 Mar. 2006

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• Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors., Kakoki Masao;Kizer Catherine M;Yi Xianwen;Takahashi Nobuyuki;Kim Hyung-Suk;Bagnell C Robert;Edgell Cora-Jean S;Maeda Nobuyo;Jennette J Charles;Smithies Oliver, The Journal of clinical investigation, 116(5), 1302-1309, 06 Apr. 2006

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• Quantitative effects of common genetic variations in the 3'UTR of the human LDL-receptor gene and their associations with plasma lipid levels in the Atherosclerosis Risk in Communities study., Muallem Hind;North Kari E;Kakoki Masao;Wojczynski Mary K;Li Xia;Grove Megan;Boerwinkle Eric;Wilhelmsen Kirk C;Heiss Gerardo;Maeda Nobuyo, Human genetics, 121(3-4), 421-431, 02 Feb. 2007

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• Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury., Kakoki Masao;McGarrah Robert W;Kim Hyung-Suk;Smithies Oliver, Proceedings of the National Academy of Sciences of the United States of America, 104(18), 7576-7581, 23 Apr. 2007

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• Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice., Kakoki Masao;Sullivan Kelli A;Backus Carey;Hayes John M;Oh Sang Su;Hua Kunjie;Gasim Adil M H;Tomita Hirofumi;Grant Ruriko;Nossov Sarah B;Kim Hyung-Suk;Jennette J Charles;Feldman Eva L;Smithies Oliver, Proceedings of the National Academy of Sciences of the United States of America, 107(22), 10190-10195, 17 May 2010

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• Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice., Wende Adam R;Soto Jamie;Olsen Curtis D;Pires Karla M P;Schell John C;Larrieu-Lahargue Frederic;Litwin Sheldon E;Kakoki Masao;Takahashi Nobuyuki;Smithies Oliver;Abel E Dale, Endocrinology, 151(8), 3536-3542, 25 May 2010

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• Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney., Vashistha Himanshu;Singhal Pravin C;Malhotra Ashwani;Husain Mohammad;Mathieson Peter;Saleem Moin A;Kuriakose Cyril;Seshan Surya;Wilk Anna;Delvalle Luis;Peruzzi Francesca;Giorgio Marco;Pelicci Pier Giuseppe;Smithies Oliver;Kim Hyung-Suk;Kakoki Masao;Reiss Krzysztof;Meggs Leonard G, American journal of physiology. Renal physiology, 303(12), F1629-F1640, 26 Sep. 2012

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• Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1., Kakoki Masao;Pochynyuk Oleh M;Hathaway Catherine M;Tomita Hirofumi;Hagaman John R;Kim Hyung-Suk;Zaika Oleg L;Mamenko Mykola;Kayashima Yukako;Matsuki Kota;Hiller Sylvia;Li Feng;Xu Longquan;Grant Ruriko;Bertorello Alejandro M;Smithies Oliver, Proceedings of the National Academy of Sciences of the United States of America, 110(14), 5600-5605, 15 Mar. 2013

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• The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension., Bai Xue;Lenhart Kaitlin C;Bird Kim E;Suen Alisa A;Rojas Mauricio;Kakoki Masao;Li Feng;Smithies Oliver;Mack Christopher P;Taylor Joan M, Nature communications, 4, 2910, 2013

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• Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade., Hathaway Catherine K;Grant Ruriko;Hagaman John R;Hiller Sylvia;Li Feng;Xu Longquan;Chang Albert S;Madden Victoria J;Bagnell C Robert;Rojas Mauricio;Kim Hyung-Suk;Wu Bingruo;Zhou Bin;Smithies Oliver;Kakoki Masao, Proceedings of the National Academy of Sciences of the United States of America, 112(16), 5141-5146, 06 Apr. 2015

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• Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice., Hathaway Catherine K;Gasim Adil M H;Grant Ruriko;Chang Albert S;Kim Hyung-Suk;Madden Victoria J;Bagnell C Robert;Jennette J Charles;Smithies Oliver;Kakoki Masao, Proceedings of the National Academy of Sciences of the United States of America, 112(18), 5815-5820, 20 Apr. 2015

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• High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy., Hathaway Catherine K;Chang Albert S;Grant Ruriko;Kim Hyung-Suk;Madden Victoria J;Bagnell C Robert;Jennette J Charles;Smithies Oliver;Kakoki Masao, Proceedings of the National Academy of Sciences of the United States of America, 113(8), 2218-2222, 08 Feb. 2016

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Review paper
• The kallikrein-kinin system in health and in diseases of the kidney., Kakoki Masao;Smithies Oliver, Kidney international, 75(10), 1019-1030, 04 Feb. 2009

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• Mouse models of diabetic nephropathy., Brosius Frank C;Alpers Charles E;Bottinger Erwin P;Breyer Matthew D;Coffman Thomas M;Gurley Susan B;Harris Raymond C;Kakoki Masao;Kretzler Matthias;Leiter Edward H;Levi Moshe;McIndoe Richard A;Sharma Kumar;Smithies Oliver;Susztak Katalin;Takahashi Nobuyuki;Takahashi Takamune; , Journal of the American Society of Nephrology : JASN, 20(12), 2503-2512, 03 Sep. 2009

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• The kallikrein-kinin system and oxidative stress., Kayashima Yukako;Smithies Oliver;Kakoki Masao, Current opinion in nephrology and hypertension, 21(1), 92-96, Jan. 2012

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• The kallikrein-kinin system in diabetic nephropathy., Tomita Hirofumi;Sanford Ryan B;Smithies Oliver;Kakoki Masao, Kidney international, 81(8), 733-744, 08 Feb. 2012

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• Transforming growth factor beta1 and aldosterone., Matsuki Kota;Hathaway Catherine K;Chang Albert S;Smithies Oliver;Kakoki Masao, Current opinion in nephrology and hypertension, 24(2), 139-144, Mar. 2015

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• The role of transforming growth factor β1 in the regulation of blood pressure., Matsuki Kota;Hathaway Catherine K;Lawrence Marlon G;Smithies Oliver;Kakoki Masao, Current hypertension reviews, 10(4), 223-238, 2014

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• Transforming growth factor-β1 and diabetic nephropathy., Chang Albert S;Hathaway Catherine K;Smithies Oliver;Kakoki Masao, American journal of physiology. Renal physiology, 310(8), F689-F696, 30 Dec. 2015

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Unclear
• Inhibition of cell surface GRP78 and activated α2M interaction attenuates kidney fibrosis., Trink Jackie;Nmecha Ifeanyi Kennedy;Pilely Katrine;Li Renzhong;Yang Zi;Kwiecien Sydney;MacDonald Melissa;Gao Bo;Mamai Mariam A;Lu Chao;Bajwa Urooj F;Uppal Nikhil;Fredenburgh James C;Kakoki Masao;Pizzo Salvatore V;Rullo Anthony F;Lanktree Matthew B;Weitz Jeffrey I;Palarasah Yaseelan;Krepinsky Joan C, JCI insight, 10(24), 22 Dec. 2025

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• Proximal aortic aneurysms in mice underexpressing transforming growth factor-β1., Kakoki Masao;Hagaman John R;Terajima Masahiko;Nagasawa Masako;Uoshima Katsumi;Yamauchi Mitsuo;Smithies Oliver;Kansaku Kenji, The journal of physiological sciences : JPS, 75(2), 100024, 14 May 2025

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学内助成金

• 01 Apr. 2023, 31 Mar. 2024, 1000000

委託研究費

• 01 Apr. 2023, 31 Mar. 2024, 2000000