城島輝雄　JIYOUJIMA TERUO　ジヨウジマ テルオ

研究者情報

研究者情報

• 氏名

  城島輝雄, ジヨウジマ テルオ

所属

• 内科学(内分泌代謝)(壬生), 学内准教授

研究業績

論文

原著論文
• Circulating CD4+PD-1+ and CD8+PD-1+ T cells are profoundly decreased at the onset of fulminant type 1 diabetes and are restored by treatment, contrasting with CD4+CD25+FoxP3+ regulatory T cells., Iijima T, Kato K, Jojima T, Tomotsune T, Fukushima M, Suzuki K, Aso Y, Diabetes Res Clin Pract, 133, 10-12, 2017年11月

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• Liraglutide, a GLP-1 receptor agonist, inhibits vascular smooth muscle cell proliferation by enhancing AMP-activated protein kinase and cell cycle regulation, and delays atherosclerosis in ApoE deficient mice., Jojima T, Uchida K, Akimoto K, Tomotsune T, Yanagi K, Iijima T, Suzuki K, Kasai K, Aso Y, Atherosclerosis , 261, 44-51, 2017年06月

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• Empagliflozin (an SGLT2 inhibitor), alone or in combination with linagliptin (a DPP-4 inhibitor), prevents steatohepatitis in a novel mouse model of non-alcoholic steatohepatitis and diabetes., Jojima T, Tomotsune T, Iijima T, Akimoto K, Suzuki K, Aso Y, Diabetol Metab Syndr, 8, 45, 2016年07月

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• Sitagliptin, a DPP-4 inhibitor, alters the subsets of circulating CD4+ T cells in patients with type 2 diabetes., Aso, Y, Fukushima M, Sagara M, Jojima T, Iijima T, Suzuki K, Momobayashi M, Kasai K, Inukai T., Diabetes Res Clin Pract, 110（3）, 250-256, 2015年12月
• Sitagliptin, a dipeptidyl peptidase-4 inhibitor, increases the number of circulating CD34+CXCR4+cells in patients with type 2 diabetes, Aso, Y, Jojima T, Iijima T, Suzuki K, Terasawa T, Fukushima M, Momobayashi M, Hara K, Takebayashi K, Kasai K, Inukai T., Endocrine, 50（3）, 659-664, 2015年12月

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• Greater Efficacy and Improved Endothelial Dysfunction in Untreated Type 2 Diabetes with Liraglutide versus Sitagliptin, Suzuki K, Tanaka S, Aoki C, Kato K, Jojima T, Aso Y, Dokkyo J Med Sci, 41（3）, 211-220, 2014年10月
• The serum level of soluble CD26/dipeptidyl peptidase 4 increases in response to acute hyperglycemia after an oral glucose load in healthy subjects: association with high-molecular weight adiponectin and hepatic enzymes., Aso Y, Terasawa T, Kato K, Jojima T, Suzuki K, Iijima T, Kawagoe Y, Mikami S, Kubota Y, Inukai T, Kasai K., Transl Res., 162（5）, 309-316, 2013年11月

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• Telmisartan inhibits cytokine-induced nuclear factor-kappaB activation independently of the peroxisome proliferator-activated receptor-gamma., Nakano A, Hattori Y, Aoki C, Jojima T, Kasai K, Hypertens Res, 32（9）, 765-769, 2009年09月

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• Glimepiride upregulates eNOS activity and inhibits cytokine-induced NF-kappaB activation through a phosphoinoside 3-kinase-Akt-dependent pathway, Jojima T, Suzuki K, Hirama N, Uchida K, Hattori Y, Diabetes Obes Metab, 11（2）, 143-149, 2009年02月

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• Time-restricted feeding prevents high-fat and high-cholesterol diet-induced obesity but fails to ameliorate atherosclerosis in apolipoprotein E-knockout mice., Inoue Ken-Ichi;Toyoda Shigeru;Jojima Teruo;Abe Shichiro;Sakuma Masashi;Inoue Teruo, Experimental animals, 70（2）, 194-202, 2020年12月03日

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• Teneligliptin, a DPP-4 Inhibitor, Decreases Plasma Levels of Inflammatory Chemokines During a Standard Meal Test in Patients With Type 2 Diabetes., Aso Yoshimasa;Kase Masato;Sagara Masaaki;Sakurai Shintaro;Iijima Toshie;Tomaru Takuya;Jojima Teruo;Usui Isao, The American journal of the medical sciences, 360（3）, 261-267, 2020年

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• Empagliflozin decreases the plasma concentration of plasminogen activator inhibitor-1 (PAI-1) in patients with type 2 diabetes: Association with improvement of fibrinolysis., Sakurai Shintaro;Jojima Teruo;Iijima Toshie;Tomaru Takuya;Usui Isao;Aso Yoshimasa, Journal of diabetes and its complications, 34（11）, 107703, 2020年

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• Empagliflozin increases plasma levels of campesterol, a marker of cholesterol absorption, in patients with type 2 diabetes: Association with a slight increase in high-density lipoprotein cholesterol., Jojima Teruo;Sakurai Shintaro;Wakamatsu Sho;Iijima Toshie;Saito Masahiro;Tomaru Takuya;Kogai Takahiko;Usui Isao;Aso Yoshimasa, International journal of cardiology, 331, 243-248, 2021年02月05日

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• Acute effect of add-on therapy with tofogliflozin, a sodium glucose co-transporter 2 inhibitor, on 24-hours glucose profile and glycaemic variability evaluated by continuous glucose monitoring in patients with type 2 diabetes receiving dipeptidyl peptidase-4 inhibitors., Iijima Toshie;Hosonuma Soichiro;Kurai Hidetaka;Kajitani Hayato;Sakurai Shintaro;Tomaru Takuya;Jojima Teruo;Usui Isao;Aso Yoshimasa, International journal of clinical practice, 75（11）, e14732, 2021年08月19日

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• Serum high-molecular-weight adiponectin and response to dapagliflozin in patients with type 2 diabetes and non-alcoholic fatty liver disease., Aso Yoshimasa;Sagara Masaaki;Niitani Takafumi;Kato Kanako;Iijima Toshie;Tomaru Takuya;Jojima Teruo;Usui Isao, Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 69（7）, 1324-1329, 2021年05月20日

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• No Negative Impact of a National State of Emergency by COVID-19 Outbreak on Hemoglobin A1c Levels in Patients With Type 2 Diabetes Living in Semi-Rural Japan., Aso Yoshimasa;Iijima Toshie;Tomaru Takuya;Jojima Teruo;Usui Isao, The American journal of the medical sciences, 362（1）, 104-105, 2021年03月30日

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• Serum levels of soluble dipeptidyl peptidase-4 in type 2 diabetes are associated with severity of liver fibrosis evaluated by transient elastography (FibroScan) and the FAST (FibroScan-AST) score, a novel index of non-alcoholic steatohepatitis with significant fibrosis., Sagara Masaaki;Iijima Toshie;Kase Masato;Kato Kanako;Sakurai Shintaro;Tomaru Takuya;Jojima Teruo;Usui Isao;Aso Yoshimasa, Journal of diabetes and its complications, 35（5）, 107885, 2021年02月06日

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• Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed Mice., Kishi Haruka;Usui Isao;Jojima Teruo;Fujisaka Shiho;Wakamatsu Sho;Mizunuma-Inoue Yuiko;Niitani Takafumi;Sakurai Shintaro;Iijima Toshie;Tomaru Takuya;Tobe Kazuyuki;Aso Yoshimasa, International journal of molecular sciences, 23（23）, 2022年12月04日

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• Effects of treatment with methimazole on circulating CD4+ and CD8+ T cells positive for programed cell death protein-1 and on subsets of CD4+ T cells in untreated hyperthyroid patients with Graves' disease., Hirao Nanako;Iijima Toshie;Tanuma Dai;Ohira Eriko;Kurai Hidetaka;Shinzawa Toshimitsu;Kase Masato;Sakurai Shintaro;Tomaru Takuya;Jojima Teruo;Usui Isao;Aso Yoshimasa, Clinical endocrinology, 97（6）, 841-848, 2022年06月17日

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• Synergistic effects of liver fibrosis and sarcopenia on endothelial dysfunction and arterial stiffness in patients with type 2 diabetes., Jojima Teruo;Kurai Hidetaka;Tanuma Dai;Kajitani Hayato;Kase Masato;Inoue Yuiko;Sakurai Shintaro;Iijima Toshie;Tomaru Takuya;Usui Isao;Aso Yoshimasa, International journal of cardiology. Heart & vasculature, 41, 101071, 2022年06月16日

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• Transcription of cytochrome P450 46A1 in NIH3T3 cells is negatively regulated by FBS., Shinohara Yasutake;Ando Hiromi;Maekawa Masamitsu;Arai Maki;Horibata Yasuhiro;Satou Motoyasu;Jojima Teruo;Usui Isao;Aso Yoshimasa;Sugimoto Hiroyuki, Biochimica et biophysica acta. Molecular and cell biology of lipids, 1867（6）, 159136, 2022年03月16日

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• Switching from the tablet to the powder formulation of levothyroxine corrects severe hypothyroidism in a patient with lactose intolerance., Jojima Teruo;Shinzawa Toshimitsu;Ohira Eriko;Sakurai Shintaro;Tomaru Takuya;Iijima Toshie;Kogai Takahiko;Usui Isao;Aso Yoshimasa, Endocrine journal, 69（8）, 941-945, 2022年03月04日

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• Acute Exacerbation of Anemia with Parvovirus B19 Infection One Year after Sleeve Gastrectomy for Severe Obesity., Shinzawa Toshimitsu;Usui Isao;Hanawa Kanako;Kajitani Hayato;Sakurai Shintaro;Tomaru Takuya;Iijima Toshie;Jojima Teruo;Kojima Kazuyuki;Aso Yoshimasa, Internal medicine (Tokyo, Japan), 61（17）, 2631-2635, 2022年02月08日

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• Development of Non-alcoholic Steatohepatitis and Nodular Regenerative Hyperplasia in C57BL/6J Mice Fed a Fructose-containing Western Diet., Inoue Ken-Ichi;Yamagishi Hidetsugu;Jojima Teruo;Inoue Teruo;Toyoda Shigeru, Anticancer research, 42（1）, 609-617, 2022年01月

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症例報告
• Genetic alteration of ARMC5 in a patient diagnosed with meningioma and primary macronodular adrenal hyperplasia: a case report., Jojima Teruo;Kogai Takahiko;Iijima Toshie;Kato Kanako;Sagara Masaaki;Kezuka Atsumi;Kase Masato;Sakurai Shintaro;Akimoto Kazumi;Sakumoto Junko;Namatame Takashi;Ueki Keisuke;Hishinuma Akira;Kamai Takao;Usui Isao;Aso Yoshimasa, European journal of endocrinology, 183（6）, K7-K12, 2020年12月

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• A case of hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome with a novel frameshift variant in GATA3, p.W10Cfs40, lacks kidney malformation., Kishi Haruka;Jojima Teruo;Kogai Takahiko;Iijima Toshie;Ohira Eriko;Tanuma Dai;Konno Sachiyo;Kato Kanako;Kezuka Atsumi;Akimoto Kazumi;Sakumoto Junko;Hishinuma Akira;Tomaru Takuya;Makita Noriko;Usui Isao;Aso Yoshimasa, Clinical case reports, 8（12）, 2619-2624, 2020年12月

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• Bullous pemphigoid associated with dipeptidyl peptidase-4 inhibitor showing unfavorable outcomes despite immediate discontinuation of medication., Shinohara Yasutake;Iijima Toshie;Sakurai Shintaro;Jojima Teruo;Ohira Eriko;Hayashi Shujiro;Usui Isao;Igawa Ken;Aso Yoshimasa, Clinical case reports, 8（10）, 2007-2012, 2020年10月

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• Symptomatic hypocalcemia after treatment for hyperthyroidism in a woman with chromosome 22q11.2 deletion syndrome complicated by Graves' disease: longitudinal changes in the number of subsets of CD4 and CD8 lymphocytes after thyroidectomy., Iijima Toshie;Jojima Teruo;Hosonuma Soichiro;Ohhira Eriko;Tomaru Takuya;Kogai Takahiko;Usui Isao;Aso Yoshimasa, Endocrine journal, 68（10）, 1187-1195, 2021年10月28日

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その他
• Expectations for synergistically favorable effects of the combination therapy with DPP-4 inhibitor and SGLT2 inhibitor on cholesterol synthesis and absorption., Jojima Teruo, International journal of cardiology, 333, 213, 2021年

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書籍等出版物

• 【腎臓症候群(第2版)下-その他の腎臓疾患を含めて-】 各種病態にみられる腎障害 内分泌疾患 自己免疫性甲状腺疾患, 共著, 日本臨床社, 2012年03月

講演・口頭発表等

• バセドウ病加療中に無顆粒球症を発症し、それを契機に発見された橋本病型IgG4関連甲状腺炎の1例, 城島輝雄, 2012年11月, ポスター発表, 日本甲状腺学会, 福岡, 国内会議
• 甲状腺クリーゼの病態の解析・治療とその予後, 城島輝雄, 2012年11月, ポスター発表, 日本甲状腺学会, 国内会議
• 当院で過去5年間の2型糖尿病患者におけるミチグリニド単剤およびαGI、TZD、BG併用、BOT療法例の臨床的検討, 城島輝雄, 2012年05月, ポスター発表, 日本糖尿病学会, 国内会議
• 1型糖尿病における強化インスリン療法とGLP-1アナログliraglutideの併用療法の有効性について, 城島輝雄, 2012年05月, 口頭発表（一般）, 日本糖尿病学術集会, 横浜, 国内会議
• 肥満糖尿病患者のビクトーザを用いた治療, 城島輝雄, 2012年05月, ポスター発表, 日本糖尿病学会, 国内会議
• GLP-1analogueの抗動脈硬化作用についての検討, 城島輝雄, 2012年05月, 口頭発表（一般）, 日本糖尿病学会, 国内会議
• 極端な菜食主義者に生じた難治性骨軟化症の1例, 城島輝雄, 2012年04月, ポスター発表, 日本内分泌学会, 国内会議

公的助成金（競争的資金）

• 糖尿病性心筋障害に対する糖尿病治療薬の影響に関する基礎的検討, 科学研究費助成事業(獨協医科大学, 獨協医科大学), 城島 輝雄, 薄井 勲, 2020年04月01日 - 2025年03月31日
• テトラヒドロビオプテリンの血管内皮保護作用とその機序に関する検討, 科学研究費助成事業(獨協医科大学, 獨協医科大学, 獨協医科大学, 獨協医科大学, 獨協医科大学), 服部 良之, 城島 輝雄, 加瀬 浩之, 鈴木 國弘, 岡安 寿江