薄井勲　USUI ISAO　ウスイ イサオ

研究者情報

研究者情報

• 氏名

  薄井勲, ウスイ イサオ

所属

• 内科学(内分泌代謝)(壬生), 学内教授

研究業績

論文

原著論文
• Comparison of insulin degludec (IDeg)/insulin Aspart (IAsp) co-formulation therapy twice-daily with free combination of GLP-1 receptor agonist liraglutide plus insulin degludec in Tochigi: IDEAL Trial., Aso Yoshimasa;Takada Yoshihisa;Tomotsune Ken;Chiba Yasuko;Matsumura Mihoko;Jojima Teruo;Sato Minoru;Fujita Nobuya;Kuroda Hisamoto;Murano Shunichi;Usui Isao, International journal of clinical practice, 75（4）, e13734, 2021年04月

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• CD-1db/db mice: A novel type 2 diabetic mouse model with progressive kidney fibrosis., Mizunuma Yuiko;Kanasaki Keizo;Nitta Kyoko;Nakamura Yuka;Ishigaki Yasuhito;Takagaki Yuta;Kitada Munehiro;Li Shaolan;Liu Haijie;Li Jinpeng;Usui Isao;Aso Yoshimasa;Koya Daisuke, Journal of diabetes investigation, 11（6）, 1470-1481, 2020年11月

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• Empagliflozin decreases the plasma concentration of plasminogen activator inhibitor-1 (PAI-1) in patients with type 2 diabetes: Association with improvement of fibrinolysis., Sakurai Shintaro;Jojima Teruo;Iijima Toshie;Tomaru Takuya;Usui Isao;Aso Yoshimasa, Journal of diabetes and its complications, 34（11）, 107703, 2020年

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• Teneligliptin, a DPP-4 Inhibitor, Decreases Plasma Levels of Inflammatory Chemokines During a Standard Meal Test in Patients With Type 2 Diabetes., Aso Yoshimasa;Kase Masato;Sagara Masaaki;Sakurai Shintaro;Iijima Toshie;Tomaru Takuya;Jojima Teruo;Usui Isao, The American journal of the medical sciences, 360（3）, 261-267, 2020年

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• Acute effect of add-on therapy with tofogliflozin, a sodium glucose co-transporter 2 inhibitor, on 24-hours glucose profile and glycaemic variability evaluated by continuous glucose monitoring in patients with type 2 diabetes receiving dipeptidyl peptidase-4 inhibitors., Iijima Toshie;Hosonuma Soichiro;Kurai Hidetaka;Kajitani Hayato;Sakurai Shintaro;Tomaru Takuya;Jojima Teruo;Usui Isao;Aso Yoshimasa, International journal of clinical practice, 75（11）, e14732, 2021年08月19日

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• Serum high-molecular-weight adiponectin and response to dapagliflozin in patients with type 2 diabetes and non-alcoholic fatty liver disease., Aso Yoshimasa;Sagara Masaaki;Niitani Takafumi;Kato Kanako;Iijima Toshie;Tomaru Takuya;Jojima Teruo;Usui Isao, Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 69（7）, 1324-1329, 2021年05月20日

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• No Negative Impact of a National State of Emergency by COVID-19 Outbreak on Hemoglobin A1c Levels in Patients With Type 2 Diabetes Living in Semi-Rural Japan., Aso Yoshimasa;Iijima Toshie;Tomaru Takuya;Jojima Teruo;Usui Isao, The American journal of the medical sciences, 362（1）, 104-105, 2021年03月30日

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• Serum levels of soluble dipeptidyl peptidase-4 in type 2 diabetes are associated with severity of liver fibrosis evaluated by transient elastography (FibroScan) and the FAST (FibroScan-AST) score, a novel index of non-alcoholic steatohepatitis with significant fibrosis., Sagara Masaaki;Iijima Toshie;Kase Masato;Kato Kanako;Sakurai Shintaro;Tomaru Takuya;Jojima Teruo;Usui Isao;Aso Yoshimasa, Journal of diabetes and its complications, 35（5）, 107885, 2021年02月06日

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• Empagliflozin increases plasma levels of campesterol, a marker of cholesterol absorption, in patients with type 2 diabetes: Association with a slight increase in high-density lipoprotein cholesterol., Jojima Teruo;Sakurai Shintaro;Wakamatsu Sho;Iijima Toshie;Saito Masahiro;Tomaru Takuya;Kogai Takahiko;Usui Isao;Aso Yoshimasa, International journal of cardiology, 331, 243-248, 2021年02月05日

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• Effects of treatment with methimazole on circulating CD4+ and CD8+ T cells positive for programed cell death protein-1 and on subsets of CD4+ T cells in untreated hyperthyroid patients with Graves' disease., Hirao Nanako;Iijima Toshie;Tanuma Dai;Ohira Eriko;Kurai Hidetaka;Shinzawa Toshimitsu;Kase Masato;Sakurai Shintaro;Tomaru Takuya;Jojima Teruo;Usui Isao;Aso Yoshimasa, Clinical endocrinology, 97（6）, 841-848, 2022年06月17日

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• Synergistic effects of liver fibrosis and sarcopenia on endothelial dysfunction and arterial stiffness in patients with type 2 diabetes., Jojima Teruo;Kurai Hidetaka;Tanuma Dai;Kajitani Hayato;Kase Masato;Inoue Yuiko;Sakurai Shintaro;Iijima Toshie;Tomaru Takuya;Usui Isao;Aso Yoshimasa, International journal of cardiology. Heart & vasculature, 41, 101071, 2022年06月16日

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• Acute Exacerbation of Anemia with Parvovirus B19 Infection One Year after Sleeve Gastrectomy for Severe Obesity., Shinzawa Toshimitsu;Usui Isao;Hanawa Kanako;Kajitani Hayato;Sakurai Shintaro;Tomaru Takuya;Iijima Toshie;Jojima Teruo;Kojima Kazuyuki;Aso Yoshimasa, Internal medicine (Tokyo, Japan), 61（17）, 2631-2635, 2022年02月08日

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• Inhibition of IL-33 signaling ameliorate hepatic fibrosis with decreasing MCP-1 in a mouse model of diabetes and non-alcoholic steatohepatitis; comparison for luseogliflozin, an SGLT2 inhibitor., Wakamatsu Sho;Jojima Teruo;Hashiguchi Masaaki;Kishi Haruka;Niitani Takafumi;Sakurai Shintaro;Iijima Toshie;Kogai Takahiko;Tomaru Takuya;Usui Isao;Aso Yoshimasa, Journal of diabetes and its complications, 38（1）, 108650, 2023年11月23日

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• Hypertension and insulin resistance in adipose tissue., Usui Isao, Hypertension research : official journal of the Japanese Society of Hypertension, 46（6）, 1478-1481, 2023年04月04日

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• Acute Effect of Imeglimin Add-on Therapy on 24-h Glucose Profile and Glycemic Variability in Patients with Type 2 Diabetes Receiving Metformin., Shinohara Yasutake;Jojima Teruo;Kamiga Yusuke;Sakurai Shintaro;Iijima Toshie;Tomaru Takuya;Akutsu Ikuo;Inoue Teruo;Usui Isao;Aso Yoshimasa, Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 33（6）, 569-577, 2024年08月12日

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• Empagliflozin increases plasma levels of citrulline, histidine, and α-aminobutyric acid in patients with type 2 diabetes: effects of a sodium-glucose co-transporter 2 inhibitor on the plasma amino acid profile., Jojima Teruo;Sakurai Shintaro;Kishi Haruka;Kato Kananko;Iijima Toshie;Tomaru Takuya;Usui Isao;Aso Yoshimasa, Expert opinion on pharmacotherapy, 25（7）, 937-944, 2024年06月04日

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• High serum levels of CCL11/Eotaxin-1 are associated with diabetic sensorimotor polyneuropathy and peripheral nerve function but not with cardiac autonomic neuropathy in people with type 2 diabetes., Aso Yoshimasa;Iijima Toshie;Jojima Teruo;Saito Masahiro;Tanuma Dai;Kase Masato;Sakurai Shintaro;Tomaru Takuya;Usui Isao, Postgraduate medicine, 136（3）, 318-324, 2024年04月29日

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• Patients with diabetes and obesity exhibit characteristics in eating and coping behaviors and personality traits., Saito Masahiro;Usui Isao;Sugawara Norio;Jojima Teruo;Sakurai Shintaro;Kishi Haruka;Sagara Masaaki;Tomaru Takuya;Iijima Toshie;Shimoda Kazutaka;Yasui-Furukori Norio;Aso Yoshimasa, Diabetology international, 15（3）, 528-534, 2024年04月16日

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• Impact of inpatient management of hyperglycemia on peripheral T cell markers in patients with type 2 diabetes., Kunii Tomohisa;Usui Isao;Jojima Teruo;Shimizu Masanori;Kase Masato;Sakurai Shintaro;Tomaru Takuya;Iijima Toshie;Aso Yoshimasa, Diabetology international, 15（3）, 414-420, 2024年02月26日

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総説論文
• Common metabolic features of hypertension and type 2 diabetes., Usui Isao, Hypertension research : official journal of the Japanese Society of Hypertension, 46（5）, 1227-1233, 2023年03月03日

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• Diabetes with GLP-1R polymorphism (rs3765467) accompanied by myotonic dystrophy: A case of myotonic dystrophy with p.R131Q polymorphism at the glucagon-like peptide-1 receptor (rs3765467) resulting in marked effects of its agonist, dulaglutide., Kato Kanako;Jojima Teruo;Kogai Takahiko;Tanuma Dai;Niitani Takafumi;Sakurai Shintaro;Iijima Toshie;Tomaru Takuya;Usui Isao;Aso Yoshimasa, The American journal of the medical sciences, 369（1）, 126-130, 2024年07月08日

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症例報告
• Genetic alteration of ARMC5 in a patient diagnosed with meningioma and primary macronodular adrenal hyperplasia: a case report., Jojima Teruo;Kogai Takahiko;Iijima Toshie;Kato Kanako;Sagara Masaaki;Kezuka Atsumi;Kase Masato;Sakurai Shintaro;Akimoto Kazumi;Sakumoto Junko;Namatame Takashi;Ueki Keisuke;Hishinuma Akira;Kamai Takao;Usui Isao;Aso Yoshimasa, European journal of endocrinology, 183（6）, K7-K12, 2020年12月

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• A case of hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome with a novel frameshift variant in GATA3, p.W10Cfs40, lacks kidney malformation., Kishi Haruka;Jojima Teruo;Kogai Takahiko;Iijima Toshie;Ohira Eriko;Tanuma Dai;Konno Sachiyo;Kato Kanako;Kezuka Atsumi;Akimoto Kazumi;Sakumoto Junko;Hishinuma Akira;Tomaru Takuya;Makita Noriko;Usui Isao;Aso Yoshimasa, Clinical case reports, 8（12）, 2619-2624, 2020年12月

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• Bullous pemphigoid associated with dipeptidyl peptidase-4 inhibitor showing unfavorable outcomes despite immediate discontinuation of medication., Shinohara Yasutake;Iijima Toshie;Sakurai Shintaro;Jojima Teruo;Ohira Eriko;Hayashi Shujiro;Usui Isao;Igawa Ken;Aso Yoshimasa, Clinical case reports, 8（10）, 2007-2012, 2020年10月

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• Symptomatic hypocalcemia after treatment for hyperthyroidism in a woman with chromosome 22q11.2 deletion syndrome complicated by Graves' disease: longitudinal changes in the number of subsets of CD4 and CD8 lymphocytes after thyroidectomy., Iijima Toshie;Jojima Teruo;Hosonuma Soichiro;Ohhira Eriko;Tomaru Takuya;Kogai Takahiko;Usui Isao;Aso Yoshimasa, Endocrine journal, 68（10）, 1187-1195, 2021年10月28日

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不明
• NAD+ Metabolism Regulates Preadipocyte Differentiation by Enhancing α-Ketoglutarate-Mediated Histone H3K9 Demethylation at the PPARγ Promoter., Okabe Keisuke;Nawaz Allah;Nishida Yasuhiro;Yaku Keisuke;Usui Isao;Tobe Kazuyuki;Nakagawa Takashi, Frontiers in cell and developmental biology, 8, 586179, 2020年

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• Effects of luseogliflozin on arterial properties in patients with type 2 diabetes mellitus: The multicenter, exploratory LUSCAR study., Kario Kazuomi;Okada Kenta;Murata Mitsunobu;Suzuki Daisuke;Yamagiwa Kayo;Abe Yasuhisa;Usui Isao;Tsuchiya Norihiro;Iwashita Chie;Harada Noriko;Okawara Yukie;Ishibashi Shun;Hoshide Satoshi, Journal of clinical hypertension (Greenwich, Conn.), 22（9）, 1585-1593, 2020年

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• Bofutsushosan improves gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in mice with diet-induced obesity., Fujisaka Shiho;Usui Isao;Nawaz Allah;Igarashi Yoshiko;Okabe Keisuke;Furusawa Yukihiro;Watanabe Shiro;Yamamoto Seiji;Sasahara Masakiyo;Watanabe Yoshiyuki;Nagai Yoshinori;Yagi Kunimasa;Nakagawa Takashi;Tobe Kazuyuki, Scientific reports, 10（1）, 5544, 2020年

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• Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway., Nishida Yasuhiro;Nawaz Allah;Kado Tomonobu;Takikawa Akiko;Igarashi Yoshiko;Onogi Yasuhiro;Wada Tsutomu;Sasaoka Toshiyasu;Yamamoto Seiji;Sasahara Masakiyo;Imura Johji;Tokuyama Kumpei;Usui Isao;Nakagawa Takashi;Fujisaka Shiho;Kunimasa Yagi;Tobe Kazuyuki, Journal of cachexia, sarcopenia and muscle, 11（1）, 241-258, 2020年

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• Relationship between reduced heart rate variability and increased arterial stiffness evaluated by the cardio-ankle vascular index in people with type 2 diabetes., Kase Masato;Iijima Toshie;Niitani Takafumi;Sagara Masaaki;Sakurai Shintaro;Tomaru Takuya;Jojima Teruo;Usui Isao;Aso Yoshimasa, Diabetology international, 14（1）, 94-102, 2022年09月29日

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