Researchers Database
SHIMIZU HIROAKI
Affiliation： Department of Biochemistry Position： Assistant Professor | |||
Last Updated :2024/05/23
Research achievements
Awards
- Mar. 2015, The Endocrine Society Annual Meeting, Outstanding Abstract Award, The role of NCoR and SMRT in nuclear receptor sibnaling, Shimizu H, Astapova I, Ye F, Bilban M, Cohen RN, Hollenberg AN
Published Papers
- NCoR1 and SMRT play unique roles in thyroid hormone action in vivo, Shimizu H, Astapova I, Ye F, Bilban M, Cohen RN, Hollenberg AN, Mol Cell Biol, 35(3), 555-565, Feb. 2015
- Effects of twice-daily injections of premixed insulin analog on glycemic control in type 2 diabetic patients, Shimizu H, Monden T, Matsumura M, Domeki N, Kasai K, Yonsei Med J, 51(6), 845-849, Nov. 2010
- Effects of changeover from voglibose to acarbose on postprandial triglycerides in type 2 diabetes mellitus patients, Matsumura M, Monden T, Miyashita Y, Kawagoe Y, Shimizu H, Nakatani Y, Domeki N, Yanagi K, Ikeda S, Kasai K, Adv Ther, 26(6), 660-666, Jun. 2009
- Dokkyo J Med Sci, 37(1), T11-T17, Mar. 2010
- A case of myeloma with hypercalcemia caused by high serum concentrations of both parathyroid hormone-related peptide (PTHrP) and macrophage inflammatory protein-1alpha (MIP-1alpha), Shimizu H, Monden T, Tomotsune T, Nakatani Y, Domeki N, Matsumura M, Jojima T, Kawagoe Y, Kasai K, Intern Med, 50(24), 2993-2996, 2011
- Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action, Shimizu H, Lu Y, Vella KR, Damilano F, Astapova I, Amano I, Ritter M, Gallop MR, Rosenzweig AN, Cohen RN, Hollenberg AN, PLOSONE, 14(8), Aug. 2019
- NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor, Mendoza A, Astapova I, Shimizu H, Gallop MR, Al-Sowaimel L, MacGowan SMD, Bergmann T, Berg AH, Tenen DE, Jacobs C, Lyubetskaya A, Tsai L, Hollenberg AN, PNAS, 114(40), E8458-E8467, Oct. 2017
- Nuclear corepressor SMRT acts as a strong regulator of both β-oxidation and suppressor of fibrosis in the differentiation process of mouse skeletal muscle cells., Shimizu H, Horibata Y, Amano I, Ritter MJ, Domae M, Ando H, Sugimoto H, Cohen RN, Hollenberg AN., PLOSONE, 17(12), Dec. 2022
Original paper
Books etc
Presentations
- The role of NCoR and SMRT in nuclear receptor sibnaling, Shimizu H, Astapova I, Ye F, Bilban M, Cohen RN, Hollenberg AN, Mar. 2015, Oral presentation, The Endocrine Society Annual Meeting, San Diego, CA, True
- The role of NCoR and SMRT in thyroid hormone action and metabolic disease, Shimizu H, Astapova I, Ye F, Bilban M, Cohen RN, Hollenberg AN, Oct. 2013, Oral presentation, 83rd Annual Meeting of the American Thyroid Association, San Juan, PR, True
- The Role of SMRT in Thyroid Hormone Receptor Signaling, Hiroaki Shimizu, Federico Damilano, Seung-Ah Lee, Anthony N Rosenzweig,William S Blaner, Ronald N Cohen and Anthony N Hollenberg, Keystone Symposia on Molecular and Cellular Biology, Jan. 2016, Poster presentation, Keystone Symposia on Molecular and Cellular Biology, Snowbird, UT, True
- SMRT Acts as an Important Regulator for Both Beta-Oxidation and the Maturation of Myogenesis in Mouse C2C12 Cell, Hiroaki Shimizu, MD, PhD, Yasuhiro Horibata, PhD, Chieko Aoyama, PhD, Izuki Amano, MD, PhD, Megan Ritter, MD, Hiromi Ando, PhD, Hiroyuki Sugimoto, MD, PhD, Anthony Neil Hollenberg, MD, Jun. 2020, Poster presentation, The Endocrine Society Annual Meeting, San Francisco, CA, True
- Role of the Nuclear Receptor Corepressors Ncor1 and Smrt in Adult Mice, Izuki Amano, Lu Yu, Lujain Al-Sowaimel, Megan J Ritter, Hiroaki Shimizu, Ronald N Cohen, Anthony N Hollenberg , Mar. 2018, Oral presentation, The Endocrine Society Annual Meeting, Chicago, IL, True
Public grant (competitive fund)
- Elucidation of anti-obese mechanism via the retinoic acid receptor signal controlled by SMRT, 科学研究費助成事業(獨協医科大学), Hiroaki Shimizu, 01 Apr. 2018 - 31 Mar. 2021