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OOKAWA NORIAKI

Position： Associate Professor
Last Updated :2025/06/23

Profiles

Profiles

  • 氏名

    OOKAWA NORIAKI

Affiliation

  • Associate Professor

Profile and Settings

Research Interests

  • memory
  • learning

Research Experience

  • Apr. 1999, Mar. 2002
  • Apr. 2002, May 2008
  • Jun. 2008, Sep. 2009
  • Oct. 2009, Jan. 2010
  • Feb. 2010, Nov. 2015
  • Dec. 2015, Jun. 2019
  • Oct. 2016, Mar. 2020
  • Jul. 2019

Association Memberships

  • Society for Neuroscience

Research achievements

Awards

  • 14 Mar. 2025
  • 10 Feb. 2019

Published Papers

    Original paper
  • Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep, Ghandour K#, Haga T#, Ohkawa N#, Fung CCA, Nomoto M, Fayed MR, Asai H, Sato M, Fukai T, Inokuchi K, Nature Communications, 16, 3618, 28 Apr. 2025
    DOI
  • Multipoint MicroLED probes for selective neural stimulation in optogenetics, Okui A., Moriya K., Kai N., Yamada M., Nishikawa A., Loesing A., Ohkawa N., Sekiguchi H., Japanese Journal of Applied Physics, 64, 048005, 14 Apr. 2025
    DOI
  • Photopharmacological modulation of hippocampal local field potential by caged-glutamate with MicroLED probe., Okada S#, Ohkawa N#,*, Moriya K, Saitoh Y, Ishikawa M, Oya K, Nishikawa A, Sekiguchi H*, Neuropsychopharmacology Reports, 44(3), 658-662, Aug. 2024
    DOI
  • Activation of prefrontal parvalbumin interneurons ameliorates working memory deficit even under clinically comparable antipsychotic treatment in a mouse model of schizophrenia, Arime Y.*, Saitoh Y., Ishikawa M., Kamiyoshihara C., Uchida Y., Fujii K., Takao K., Akiyama K., Ohkawa N.*, Neuropsychopharmacology, 49, 720-730, Mar. 2024
    DOI
  • A novel micro-ECoG recording method for recording multisensory neural activity from the parietal to temporal cortices in mice, Setogawa S., Kanda R., Tada S., Hikima T., Saitoh Y., Ishikawa M., Nakada S., Seki F., Hikishima K., Matsumoto H., Mizuseki K., Fukayama O., Osanai M., Sekiguchi H.*, Ohkawa N.*, Molecular Brain, 16, 38, 03 May 2023
    DOI
  • Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles, Nomoto M., Ohkawa N., Inokuchi K., Oishi N., Molecular Brain, 16, 12, Jan. 2023
    DOI
  • Sevoflurane-induced amnesia is associated with inhibition of hippocampal cell ensemble activity after learning., Kameyama A, Asai H, Nomoto M, Ohno S, Ghandour K, Ohkawa N, Saitoh Y, Yamazaki M, Inokuchi K, Biology Open, 11(12), bio059666, Dec. 2022
    DOI
  • MicroLED neural probe for effective in vivo optogenetic stimulation., Yasunaga H, Takeuchi H, Mizuguchi K, Nishikawa A, Loesing A, Ishikawa M, Kamiyoshihara C, Setogawa S, Ohkawa N, Sekiguchi H, Optics Express, 30(22), 40292-40305, Oct. 2022
    DOI
  • Adhesionable flexible GaN-based microLED array film to brain surface for in vivo optogenetic stimulation., Sekiguchi H., Matsuhira H., Kanda R., Tada S., Kitade T., Tsutsumi M., Nishikawa A., Loesing A., Fukunaga I., Setogawa S., Ohkawa N., Applied Physics Express, 15, 046501, 17 Mar. 2022
    DOI
  • A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating., Suzuki A., Kosugi S., Murayama E., Sasakawa E., Ohkawa N., Konno A., Hirai H., Inokuchi K., Nature Communications, 13, 41, 11 Jan. 2022
    DOI
  • Selective targeting of mRNA and the following protein synthesis of CaMKIIalpha at the long-term potentiation-induced site., Nihonmatsu I.#, Ohkawa N.#,*, Saitoh Y.#, Okubo-Suzuki R., Inokuchi K., Biology Open, 9, bio042861, 2020
    DOI
  • Pcdhbeta deficiency affects hippocampal CA1 ensemble activity and contextual fear discrimination., Asai H., Ohkawa N., Saitoh Y., Ghandour K., Murayama E., Nishizono H., Matsuo M., Hirayama T., Kaneko R., Muramatsu S-I., Yagi T., Inokuchi K., Molecular Brain, 13, 7, 2020
    DOI
  • Orchestrated ensemble activities constitute a hippocampal memory engram., Ghandour K.#, Ohkawa N.#,*, Fung C. C. A.#, Asai H., Saitoh Y., Takekawa T., Okubo-Suzuki R., Soya S., Nishizono H., Matsuo M., Sato M., Ohkura M., Nakai J., Hayashi Y., Sakurai T., Osanai M., Kitamura T., Fukai T., Inokuchi K.*, Nature Communications, 10, 2637, 2019
    DOI
  • Powerful homeostatic control of oligodendroglial lineage by PDGFRalpha in adult brain., Đặng T.C., Ishii Y., Nguyen V., Yamamoto S., Hamashima T., Okuno N., Nguyen Q.L., Sang Y., Ohkawa N., Saitoh Y., Shehata M., Takakura N., Fujimori T., Inokuchi K., Mori H., Andrae J., Betsholtz C., Sasahara M., Cell Reports, 27, 1073-1089.e5, 2019
    DOI
  • Artificial association of memory events by optogenetic stimulation of hippocampal CA3 cell ensembles., Oishi N., Nomoto M., Ohkawa N., Saitoh Y., Sano Y., Tsujimura S., Nishizono H., Matsuo M., Muramatsu S., Inokuchi K., Molecular Brain, 12, 2, 2019
    DOI
  • Adult neurogenesis conserves the hippocampal memory capacity., Alam M. J., Kitamura T., Saitoh Y., Ohkawa N., Kondo T., Inokuchi K., Journal of Neuroscience, 38, 6854-6863, 2018
    DOI
  • Overlapping memory trace indispensable for linking, but not recalling, individual memories., Yokose J., Okubo-Suzuki R., Nomoto M., Ohkawa N., Nishizono H., Suzuki A., Matsuo M., Tsujimura S., Takahashi Y., Nagase M., Watabe A. M., Sasahara M., Kato F., Inokuchi K., Science, 355, 398-403, 2017
    DOI
  • Cellular tagging as a neural network mechanism for behavioral tagging., Nomoto M., Ohkawa N., Nishizono H., Yokose J., Suzuki A., Matsuo M., Tsujimura S., Takahashi Y., Nagase M., Watabe A. M., Kato F., Inokuchi K., Nature Communications, 7, 12319, 2016
    DOI
  • Targeting of ribosomal protein S6 to dendritic spines by in vivo high frequency stimulation to induce long-term potentiation in the dentate gyrus., Nihonmatsu I.#, Ohkawa N.#, Saitoh Y., Inokuchi K., Biology Open, 4, 1387-1394, 2015
    DOI
  • Artificial association of pre-stored information to generate a qualitatively new memory., Ohkawa N., Saitoh Y., Suzuki A., Tsujimura S., Murayama E., Kosugi S., Nishizono H., Matsuo M., Takahashi Y., Nagase M., Sugimura Y. K., Watabe A. M., Kato F., Inokuchi K., Cell Reports, 11, 261-269, 2015
    DOI
  • Spine formation pattern of adult-born neurons is differentially modulated by the induction timing and location of hippocampal plasticity., Ohkawa N., Saitoh Y., Tokunaga E., Nihonmatsu I., Ozawa F., Murayama A., Shibata F., Kitamura T., Inokuchi K., PLoS One, 7, e45270, 2012
    DOI
  • Neuronal-stimulation induces autophagy in hippocampal neurons that is involved in AMPA receptor degradation after chemical LTD., Shehata M., Matsumura H., Okubo-Suzuki R., Ohkawa N., Inokuchi K., Journal of Neuroscience, 32, 10413-10422, 2012
    DOI
  • N-acetyltransferase ARD1-NAT1 regulates neuronal dendritic development., Ohkawa N., Sugisaki S., Fujitani K., Tokunaga E., Hayasaka T., Setou M., Inokuchi K., Genes to Cells, 13, 1171-1183, 2008
    DOI
  • Motor discoordination of transgenic mice specifically overexpressing a microtubule destabilizer, stathmin, in Purkinje cells., Ohkawa N., Hashimoto K., Hino T., Migishima R., Yokoyama M., Kano M., Inokuchi K., Neuroscience Research, 59, 93-100, 2007
    DOI
  • The microtubule destabilizer stathmin mediates the development of dendritic arbors in neuronal cells., Ohkawa N., Fujitani K., Tokunaga E., Furuya S., Inokuchi K., Journal of Cell Science, 120, 1447-1456, 2007
    DOI
  • Molecular cloning and characterization of NARF, Neural Activity-related RING Finger protein: a new member of the RBCC family is a candidate for the partner of Myosin V., Ohkawa N.*, Kokura K., Matsu-ura T., Obinata T., Konishi Y., Tamura T., Journal of Neurochemistry, 78, 75-87, 2001
    DOI
  • Identification of the C-terminal activation domain of the NeuroD-related factor (NDRF)., Konishi Y., Aoki T., Ohkawa N., Matsu-ura T., Mikoshiba K., Tamura T., Nucleic Acids Research, 28, 2406-2412, 2000
    DOI
  • Activation of the mouse inositol 1,4,5-trisphosphate receptor type 1 promoter by AP-2., Ohkawa N., Konishi Y., Shimada M., Makino Y., Yoshikawa S., Mikoshiba K., Tamura T., Gene, 229, 11-19, 1999
    DOI
  • Distribution of AP-2 subtypes in the adult mouse brain., Shimada M., Konishi Y., Ohkawa N., Ohtaka-Maruyama C., Hanaoka F., Makino Y., Tamura T., Neuroscience Research, 33, 275-280, 1999
    DOI
  • Transcriptional regulation of mouse type 1 inositol 1,4,5-trisphosphate receptor gene by NeuroD-related factor., Konishi Y., Ohkawa N., Makino Y., Ohkubo H., Kageyama R., Furuichi T., Mikoshiba K., Tamura T., Journal of Neurochemistry, 72, 1717-1724, 1999
    DOI
  • Cloning of a novel rat gene, DB83, that encodes a putative membrane protein., Nakadai T., Kishimoto T., Kokura K., Ohkawa N., Makino Y., Muramatsu M., Tamura T., DNA Research, 5, 315-317, 1998
    DOI
  • Enhanced expression of a new class of liver-enriched b-Zip transcription factors, hepatocarcinogenesis-related transcription factor, in hepatocellular carcinomas of rats and humans., Kishimoto T., Kokura K., Ohkawa N., Makino Y., Yoshida M., Hirohashi S., Niwa S., Muramatsu M., Tamura T., Cell Growth and Differentiation, 9, 337-344, 1998

MISC

  • Dual roles of idling moments in past and future memories, Ghandour K#, Haga T#, Ohkawa N#, Fung CCA, Nomoto M, Fayed MR, Asai H, Sato M, Fukai T, Inokuchi K, bioRxiv, 01 Jul. 2024
    DOI
  • Activation of prefrontal parvalbumin interneurons ameliorates treatment-resistant working memory deficit even under continuous antipsychotic treatment in a mouse model of schizophrenia, Arime Y.*, Saitoh Y., Ishikawa M., Kamiyoshihara C., Uchida Y., Fujii K, Takao K., Akiyama K., Ohkawa N.*, bioRxiv, 01 Mar. 2023
    DOI
  • Imaging of neuronal activity in freely behaving animals using miniature microscope, 52(3), 327-330, 28 Feb. 2023
  • A novel micro-ECoG recording method for recording multisensory neural activity from the parietal to temporal cortices in mice, Setogawa S, Kanda R, Tada S, Hikima T, Saitoh Y, Ishikawa M, Nakada S, Seki F, Hikishima K, Matsumoto H, Mizuseki K, Fukayama O, Osanai M, Sekiguchi H, Ohkawa N, bioRxiv, 04 Oct. 2022
    DOI
  • HOTARU: Automatic sorting system for large scale calcium imaging data, Takekawa T, Nomoto M, Asai H, Ohkawa N, Okubo-Suzuki R, Ghandour K, Sato M, Ohkura M, Nakai J, Muramatsu S-I, Hayashi Y, Inokuchi K, Fukai T, bioRxiv, 07 Apr. 2022
    DOI
  • Visualization and manipulation of memory by light, 52(2), 12-16, 2020
  • Guide for Ca2+ imaging from deep brain regions, 27(2), 74-86, 2020
  • Creation of artificial associative memory through engram cell ensembles, 33(1), 2-9, 2019
  • Automatic sorting system for large calcium imaging data, Takekawa T, Asai H, Ohkawa N, Nomoto M, Okubo-Suzuki R, Ghandour K, Sato M, Hayashi Y, Inokuchi K, Fukai T, bioRxiv, 09 Nov. 2017
    DOI
  • Experience-dependent integration of adult-born neurons into hippocampal circuits, 30(5), 521-527, 2011
  • Transcriptional regulation of neural-specific genes., Tamura T., Konishi Y., Ohkawa N., Shimada M., Aoki T., Makino Y., Recent Research Developments in Neurochemistry, 2, 125-137, 1999

Books etc

  • Behavioral Neurogenetics, Daisuke Yamamoto (ed.), Neuromethods Vol. 181, Miniature microscopy of hippocampal CA1 to identify engram cells and record calcium transients for analyses of ensemble activities., Joint work, Ohkawa N., Ghandour K., Springer, Jun. 2022, 157-174, English, Textbook
    DOI
  • Joint work, Apr. 2022, 296, 93-113, ISBN978-4-910513-06-5
  • Contributor, 2017
    DOI
  • Contributor, 2015
  • Contributor, 2014, Dictionary or encycropedia
    DOI
  • Contributor, 1999, Japanese, Textbook

Presentations

  • Mereology for organizing episodic memories in the hippocampus, Noriaki Ohkawa, The 100th Anniversary Annual Meeting of The Physiological Society of Japan, 16 Mar. 2023, 14 Mar. 2023, 16 Mar. 2023, Nominated symposium
  • Orchestration of sub-ensemble activities of engram cells constitutes a whole picture of one episodic memory, Noriaki Ohkawa, The 126th Annual Meeting of The Japanese Association of Anatomists / The 98th Annual Meeting of The Physiological Society of Japan, 28 Mar. 2021, 28 Mar. 2021, 30 Mar. 2021, Nominated symposium
  • Orchestrated ensemble activities constitute a hippocampal memory engram, The 57th Annual Meeting of the BSJ, 25 Sep. 2019, Nominated symposium
  • Ensemble representation of contextual memory in hippocampal engram cells, 27 Jul. 2018, Nominated symposium
  • Optogenetic approaches to reveal association and consolidation of memories in engram cell ensembles., Ohkawa N., 9th Optogenetics Research Society Japan International Symposium, 21 Oct. 2017, Invited oral presentation, Sendai
  • Integration pattern of adult-born neurons into preexisting circuit is modulated by the hippocampal plasticity., Ohkawa N., Inokuchi K., The 6th International Conference of Neurons and Brain Diseases, 03 Aug. 2011, Toyama

学内助成金

  • Jun. 2023, 31 Mar. 2024, 800000
  • Sep. 2022, 31 Mar. 2023, 400000
  • Jun. 2022, 31 Mar. 2023, 800000
  • Jun. 2021, 31 Mar. 2022, 900000
  • Sep. 2020, 31 Mar. 2021, 400000
  • Sep. 2020, 31 Mar. 2021, 400000

委託研究費

  • Dec. 2023, Dec. 2024, 500000
  • 01 Apr. 2023, 31 Mar. 2026, 3000000
  • Dec. 2022, Dec. 2023, 1200000
  • 2021, 2023, 3000000
  • 2020, 2021, 800000
  • 2020, 2022, 10000000
  • 2020, 2022, 2000000
  • 2020, 2021, 600000
  • 2019, 800000
  • 2019, 2020, 1500000
  • 2018, 500000
  • 2017, 2019, 5000000
  • 2016, 2017, 3000000
  • 2015, 2017, 2000000
  • 2015, 800000
  • 2015, 600000
  • 2015, 3000000
  • 2013, 800000

Social contributions

Academic Contribution

  • Competition etc, 2024, 27 Jul. 2025
    Permalink
  • Competition etc, 2022, 04 Aug. 2023
    Permalink
  • Competition etc, 2021, 03 Jul. 2022
    Permalink
  • Academic society etc, 19 Sep. 2018, 20 Sep. 2018
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