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KOBAYASHI HISATO

Position： Professor
Last Updated :2025/06/10

Profiles

Profiles

  • 氏名

    KOBAYASHI HISATO

Affiliation

  • Professor

Profile and Settings

Alternate Names

  • Hisato Kobayashi

Affiliation

  • Dokkyo Medical University, Department of Medical Genome Science, Professor, Prof lv

Research Interests

  • retrotransposon
  • Genomic imprinting
  • DNA methylation
  • Epigenetics

Research Areas

  • Life Science, Animal life science
  • Life Science, Developmental biology
  • Life Science, Applied molecular and cellular biology
  • Life Science, Genome biology

Research Experience

  • Apr. 2025, 9999, Dokkyo Medical University, Department of Medical Genome Science, Professor, Japan
  • Apr. 2021, Mar. 2025, Nara Medical University, Department of embryology, Associate Professor, Japan
  • Oct. 2018, Mar. 2021, Nara Medical University, Department of embryology, Assistant Professor/Lector
  • Oct. 2013, Sep. 2018, Tokyo University of Agriculture, 生物資源ゲノム解析センター, 准教授
  • Apr. 2012, Sep. 2013, Tokyo University of Agriculture, バイオサイエンス学科, 特任助教
  • Apr. 2008, Mar. 2012, Tokyo University of Agriculture, バイオサイエンス学科, 博士研究員
  • Apr. 2006, Mar. 2008, 東北大学 医学系研究科, 発生発達医学講座婦人科学分野, 博士研究員

Education

  • Apr. 2003, Mar. 2006, The Graduate University for Advanced Studies, School of Life Science, Department of Genetics
  • Apr. 2001, Mar. 2003, 茨城大学理工学研究科, 理工学研究科, 自然機能科学専攻

Association Memberships

  • SOCIETY FOR REPRODUCTION AND DEVELOPMENT
  • 日本エピジェネティクス研究会
  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Research achievements

Awards

  • May 2013, 日本エピジェネティクス研究会, 研究奨励賞, 小林 久人

Published Papers

    Unclear
  • Post-fertilization transcription initiation in an ancestral LTR retrotransposon drives lineage-specific genomic imprinting of ZDBF2., Hisato Kobayashi; Tatsushi Igaki; Soichiro Kumamoto; Keisuke Tanaka; Tomoya Takashima; So I Nagaoka; Shunsuke Suzuki; Masaaki Hayashi; Marilyn B Renfree; Manabu Kawahara; Shun Saito; Toshihiro Kobayashi; Hiroshi Nagashima; Hitomi Matsunari; Kazuaki Nakano; Ayuko Uchikura; Hiroshi Kiyonari; Mari Kaneko; Hiroo Imai; Kazuhiko Nakabayashi; Matthew Lorincz; Kazuki Kurimoto, eLife, 13, 02 Jun. 2025
    DOI
  • Zinc eluted from glassware is a risk factor for embryo development in human and animal assisted reproduction, Tatsuma Yao; Hisato Kobayashi; Tatsuki Hirai; Yuta Tokuoka; Mikiko Tokoro; Yuta Asayama; Yuka Suzuki; Yu Hatano; Hiroki Ikeda; Satoshi Sugimura; Takuya Yamamoto; Takahiro G Yamada; Yoshihiko Hosoi; Akira Funahashi; Noritaka Fukunaga; Yoshimasa Asada; Kazuki Kurimoto; Kazuo Yamagata, Biology of Reproduction, 02 Apr. 2025
    DOI
  • Chromosome-specific barcode system with centromeric repeat in cultivated soybean and wild progenitor., Ahmet L Tek; Kiyotaka Nagaki; Hümeyra Yıldız Akkamış; Keisuke Tanaka; Hisato Kobayashi, Life science alliance, 7(12), Dec. 2024
    DOI
  • Rat post-implantation epiblast-derived pluripotent stem cells produce functional germ cells, Kenyu Iwatsuki; Mami Oikawa; Hisato Kobayashi; Christopher A. Penfold; Makoto Sanbo; Takuya Yamamoto; Shinichi Hochi; Kazuki Kurimoto; Masumi Hirabayashi; Toshihiro Kobayashi, Cell Reports Methods, 100542-100542, Jul. 2023
    DOI
  • Conservation and divergence of canonical and non-canonical imprinting in murids., Julien Richard Albert; Toshihiro Kobayashi; Azusa Inoue; Ana Monteagudo-Sánchez; Soichiro Kumamoto; Tomoya Takashima; Asuka Miura; Mami Oikawa; Fumihito Miura; Shuji Takada; Masumi Hirabayashi; Keegan Korthauer; Kazuki Kurimoto; Maxim V C Greenberg; Matthew Lorincz; Hisato Kobayashi, Genome biology, 24(1), 48-48, 14 Mar. 2023
    DOI
  • ADAD2 functions in spermiogenesis and piRNA biogenesis in mice., Yonggang Lu; Ippei Nagamori; Hisato Kobayashi; Kanako Kojima-Kita; Kenjiro Shirane; Hsin-Yi Chang; Toru Nishimura; Takayuki Koyano; Zhifeng Yu; Julio M Castañeda; Makoto Matsuyama; Satomi Kuramochi-Miyagawa; Martin M Matzuk; Masahito Ikawa, Andrology, 11(4), 698-709, 25 Jan. 2023
    DOI
  • Upregulated Ribosomal Pathway Impairs Follicle Development in a Polycystic Ovary Syndrome Mouse Model: Differential Gene Expression Analysis of Oocytes., Natsuki Nakanishi; Satoko Osuka; Tomohiro Kono; Hisato Kobayashi; Shinya Ikeda; Bayasula Bayasula; Reina Sonehara; Mayuko Murakami; Sayako Yoshita; Natsuki Miyake; Ayako Muraoka; Yukiyo Kasahara; Tomohiko Murase; Tomoko Nakamura; Maki Goto; Akira Iwase; Hiroaki Kajiyama, Reproductive sciences (Thousand Oaks, Calif.), 04 Oct. 2022
    DOI
  • Repeated translocation of a supergene underlying rapid sex chromosome turnover in Takifugu pufferfish., Ahammad Kabir; Risa Ieda; Sho Hosoya; Daigaku Fujikawa; Kazufumi Atsumi; Shota Tajima; Aoi Nozawa; Takashi Koyama; Shotaro Hirase; Osamu Nakamura; Mitsutaka Kadota; Osamu Nishimura; Shigehiro Kuraku; Yasukazu Nakamura; Hisato Kobayashi; Atsushi Toyoda; Satoshi Tasumi; Kiyoshi Kikuchi, Proceedings of the National Academy of Sciences of the United States of America, 119(23), e2121469119, 07 Jun. 2022
    DOI
  • Functional primordial germ cell-like cells from pluripotent stem cells in rats., Mami Oikawa; Hisato Kobayashi; Makoto Sanbo; Naoaki Mizuno; Kenyu Iwatsuki; Tomoya Takashima; Keiko Yamauchi; Fumika Yoshida; Takuya Yamamoto; Takashi Shinohara; Hiromitsu Nakauchi; Kazuki Kurimoto; Masumi Hirabayashi; Toshihiro Kobayashi, Science (New York, N.Y.), 376(6589), 176-179, 08 Apr. 2022
    DOI
  • Deciphering two rounds of cell lineage segregations during bovine preimplantation development., Hiroki Akizawa; Shun Saito; Nanami Kohri; Eri Furukawa; Yoshihiro Hayashi; Hanako Bai; Masashi Nagano; Yojiro Yanagawa; Hayato Tsukahara; Masashi Takahashi; Shinjiro Kagawa; Ryouka Kawahara-Miki; Hisato Kobayashi; Tomohiro Kono; Manabu Kawahara, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(10), e21904, Oct. 2021
    DOI
  • Loop-mediated isothermal amplification (LAMP) and machine learning application for early pregnancy detection using bovine vaginal mucosal membrane., Hiroki Kunii; Tomoaki Kubo; Natsuki Asaoka; Ahmed Z Balboula; Yu Hamaguchi; Tomoya Shimasaki; Hanako Bai; Manabu Kawahara; Hisato Kobayashi; Hidehiko Ogawa; Masashi Takahashi, Biochemical and biophysical research communications, 569, 179-186, 10 Sep. 2021
    DOI
  • Dorso-ventral heterogeneity in tracheal basal stem cells., Tomomi Tadokoro; Keisuke Tanaka; Shun Osakabe; Mimoko Kato; Hisato Kobayashi; Brigid L M Hogan; Hideki Taniguchi, Biology open, 10(9), 16 Aug. 2021
    DOI
  • Dynamics of transcription-mediated conversion from euchromatin to facultative heterochromatin at the Xist promoter by Tsix., Tatsuya Ohhata; Kazuki Yamazawa; Asuka Miura-Kamio; Saori Takahashi; Satoshi Sakai; Yuka Tamura; Chiharu Uchida; Kyoko Kitagawa; Hiroyuki Niida; Ichiro Hiratani; Hisato Kobayashi; Hiroshi Kimura; Anton Wutz; Masatoshi Kitagawa, Cell reports, 34(13), 108912-108912, 30 Mar. 2021
    DOI
  • Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF., Kaichi Yoshizaki; Ryuichi Kimura; Hisato Kobayashi; Shinya Oki; Takako Kikkawa; Lingling Mai; Kohei Koike; Kentaro Mochizuki; Hitoshi Inada; Yasuhisa Matsui; Tomohiro Kono; Noriko Osumi, EMBO reports, 22(2), e51524, 05 Jan. 2021
    DOI
  • Epigenome reprogramming in the male and female germ line, Kazuki Kurimoto; Hiroki Ikeda; Hisato Kobayashi, Epigenetics and Reproductive Health, 3-25, 2021
    DOI
  • Characterization of Frond and Flower Development and Identification of FT and FD Genes From Duckweed Lemna aequinoctialis Nd., Akiko Yoshida; Ken-Ichiro Taoka; Aoi Hosaka; Keisuke Tanaka; Hisato Kobayashi; Tomoaki Muranaka; Kiminori Toyooka; Tokitaka Oyama; Hiroyuki Tsuji, Frontiers in plant science, 12, 697206-697206, 2021
    DOI
  • Canonical and Non-canonical Genomic Imprinting in Rodents., Hisato Kobayashi, Frontiers in cell and developmental biology, 9, 713878-713878, 2021
    DOI
  • Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo., Julien Richard Albert; Wan Kin Au Yeung; Keisuke Toriyama; Hisato Kobayashi; Ryutaro Hirasawa; Julie Brind'Amour; Aaron Bogutz; Hiroyuki Sasaki; Matthew Lorincz, Nature communications, 11(1), 5417-5417, 27 Oct. 2020
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  • Germline development in rat revealed by visualization and deletion of Prdm14., Toshihiro Kobayashi; Hisato Kobayashi; Teppei Goto; Tomoya Takashima; Mami Oikawa; Hiroki Ikeda; Reiko Terada; Fumika Yoshida; Makoto Sanbo; Hiromitsu Nakauchi; Kazuki Kurimoto; Masumi Hirabayashi, Development (Cambridge, England), 147(4), dev183798-dev183798, 21 Feb. 2020
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  • Food-Derived Compounds Apigenin and Luteolin Modulate mRNA Splicing of Introns with Weak Splice Sites., Masashi Kurata; Naoko Fujiwara; Ken-Ichi Fujita; Yasutaka Yamanaka; Shigeto Seno; Hisato Kobayashi; Yusaku Miyamae; Nobuyuki Takahashi; Yasuyuki Shibuya; Seiji Masuda, iScience, 22, 336-352, 20 Dec. 2019
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  • Evolution of imprinting via lineage-specific insertion of retroviral promoters., Aaron B Bogutz; Julie Brind'Amour; Hisato Kobayashi; Kristoffer N Jensen; Kazuhiko Nakabayashi; Hiroo Imai; Matthew C Lorincz; Louis Lefebvre, Nature communications, 10(1), 5674-5674, 12 Dec. 2019
    DOI
  • Distinct cell proliferation, myogenic differentiation, and gene expression in skeletal muscle myoblasts of layer and broiler chickens., Nihashi Y; Umezawa K; Shinji S; Hamaguchi Y; Kobayashi H; Kono T; Ono T; Kagami H; Takaya T, Scientific reports, 9(1), 16527-16527, Nov. 2019
    DOI
  • Signs of biological activities of 28,000-year-old mammoth nuclei in mouse oocytes visualized by live-cell imaging., Yamagata K; Nagai K; Miyamoto H; Anzai M; Kato H; Miyamoto K; Kurosaka S; Azuma R; Kolodeznikov II; Protopopov AV; Plotnikov VV; Kobayashi H; Kawahara-Miki R; Kono T; Uchida M; Shibata Y; Handa T; Kimura H; Hosoi Y; Mitani T; Matsumoto K; Iritani A, Scientific reports, 9(1), 4050-4050, Mar. 2019
    DOI
  • Global transcriptome analysis of pig induced pluripotent stem cells derived from six and four reprogramming factors., Fukuda T; Doi K; Donai K; Takahashi K; Kobayashi H; Hirano T; Nishimori K; Yasue H, Scientific data, 6, 190034-190034, Feb. 2019
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  • Tuning water-use efficiency and drought tolerance in wheat using abscisic acid receptors, Ryosuke Mega; Fumitaka Abe; June-Sik Kim; Yuuri Tsuboi; Keisuke Tanaka; Hisato Kobayashi; Yoichi Sakata; Kousuke Hanada; Hisashi Tsujimoto; Jun Kikuchi; Sean R. Cutler; Masanori Okamoto, NATURE PLANTS, 5(2), 153-+, Feb. 2019
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  • Sex-specific histone modifications in mouse fetal and neonatal germ cells., Kawabata Y; Kamio A; Jincho Y; Sakashita A; Takashima T; Kobayashi H; Matsui Y; Kono T, Epigenomics, 11(5), 543-561, Jan. 2019
    DOI
  • LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation, Julie Brind’Amour; Hisato Kobayashi; Julien Richard Albert; Kenjiro Shirane; Akihiko Sakashita; Asuka Kamio; Aaron Bogutz; Tasuku Koike; Mohammad M. Karimi; Louis Lefebvre; Tomohiro Kono; Matthew C. Lorincz, Nature Communications, 9(1), 3331-3331, Dec. 2018
    DOI
  • SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling., Mochizuki K; Tando Y; Sekinaka T; Otsuka K; Hayashi Y; Kobayashi H; Kamio A; Ito-Matsuoka Y; Takehara A; Kono T; Osumi N; Matsui Y, Development (Cambridge, England), 145(23), Dec. 2018
    DOI
  • Relationship between PIWIL4-Mediated H3K4me2 Demethylation and piRNA-Dependent DNA Methylation., Ippei Nagamori; Hisato Kobayashi; Toru Nishimura; Reina Yamagishi; Jun Katahira; Satomi Kuramochi-Miyagawa; Tomohiro Kono; Toru Nakano, Cell reports, 25(2), 350-356, 09 Oct. 2018
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  • Repression of Somatic Genes by Selective Recruitment of HDAC3 by BLIMP1 Is Essential for Mouse Primordial Germ Cell Fate Determination., Mochizuki K; Hayashi Y; Sekinaka T; Otsuka K; Ito-Matsuoka Y; Kobayashi H; Oki S; Takehara A; Kono T; Osumi N; Matsui Y, Cell reports, 24(10), 2682-2693.e6, Sep. 2018
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  • DNMTs and SETDB1 function as co-repressors in MAX-mediated repression of germ cell-related genes in mouse embryonic stem cells., Daiki Tatsumi; Yohei Hayashi; Mai Endo; Hisato Kobayashi; Takumi Yoshioka; Kohei Kiso; Shinichiro Kanno; Yuji Nakai; Ikuma Maeda; Kentaro Mochizuki; Makoto Tachibana; Haruhiko Koseki; Akihiko Okuda; Akira Yasui; Tomohiro Kono; Yasuhisa Matsui, PloS one, 13(11), e0205969, 2018
    DOI
  • Lip b 1 is a novel allergenic protein isolated from the booklouse, Liposcelis bostrychophila, O. Ishibashi; K. Sakuragi; Y. Fukutomi; Y. Kawakami; Y. Kamata; M. Sakurai; S. Nakayama; H. Uchiyama; H. Kobayashi; H. Kojima; T. Inui, ALLERGY, 72(6), 918-926, Jun. 2017
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  • Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas, Shintaro Fukushima; Satoshi Yamashita; Hisato Kobayashi; Hirokazu Takami; Kohei Fukuoka; Taishi Nakamura; Kai Yamasaki; Yuko Matsushita; Hiromi Nakamura; Yasushi Totoki; Mamoru Kato; Tomonari Suzuki; Kazuhiko Mishima; Takaaki Yanagisawa; Akitake Mukasa; Nobuhito Saito; Masayuki Kanamori; Toshihiro Kumabe; Teiji Tominaga; Motoo Nagane; Toshihiko Iuchi; Koji Yoshimoto; Masahiro Mizoguchi; Kaoru Tamura; Keiichi Sakai; Kazuhiko Sugiyama; Mitsutoshi Nakada; Kiyotaka Yokogami; Hideo Takeshima; Yonehiro Kanemura; Masahide Matsuda; Akira Matsumura; Kazuhiko Kurozumi; Keisuke Ueki; Masahiro Nonaka; Akio Asai; Nobutaka Kawahara; Yuichi Hirose; Tatusya Takayama; Yoichi Nakazato; Yoshitaka Narita; Tatsuhiro Shibata; Masao Matsutani; Toshikazu Ushijima; Ryo Nishikawa; Koichi Ichimura, ACTA NEUROPATHOLOGICA, 133(3), 445-462, Mar. 2017
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  • Inducible Transposition of a Heat-Activated Retrotransposon in Tissue Culture, Yukari Masuta; Kosuke Nozawa; Hiroki Takagi; Hiroki Yaegashi; Keisuke Tanaka; Tasuku Ito; Hideyuki Saito; Hisato Kobayashi; Wataru Matsunaga; Seiji Masuda; Atsushi Kato; Hidetaka Ito, PLANT AND CELL PHYSIOLOGY, 58(2), 375-384, Feb. 2017
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  • Spatiotemporal dynamics of OCT4 protein localization during preimplantation development in mice, Atsushi Fukuda; Atsushi Mitani; Toshiyuki Miyashita; Hisato Kobayashi; Akihiro Umezawa; Hidenori Akutsu, REPRODUCTION, 152(5), 417-430, Nov. 2016
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  • Repetitive DNA methylome analysis by small-scale and single-cell shotgun bisulfite sequencing, Hisato Kobayashi; Tasuku Koike; Akihiko Sakashita; Keisuke Tanaka; Soichiro Kumamoto; Tomohiro Kono, GENES TO CELLS, 21(11), 1209-1222, Nov. 2016
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  • GENOME-WIDE DNA METHYLATION AND TRANSCRIPTOMIC PROFILING IN PRIMARY CENTRAL NERVOUS SYSTEM GERM CELL TUMORS SUGGESTS A PRIMORDIAL GERM CELL ORIGIN FOR GERMINOMA, Koichi Ichimura; Shintaro Fukushima; Satoshi Yamashita; Hisato Kobayashi; Hirokazu Takami; Yuko Matsushita; Sakura Kuzuoka; Hiromi Nakamura; Yasushi Totoki; Yoichi Nakazato; Tatsuhiro Shibata; Masao Matsutani; Toshikazu Ushijima; Ryo Nishikawa, NEURO-ONCOLOGY, 18, 44-44, Jun. 2016
  • DNA Methylation Errors in Cloned Mouse Sperm by Germ Line Barrier Evasion, Tasuku Koike; Takuya Wakai; Yuko Jincho; Akihiko Sakashita; Hisato Kobayashi; Eiji Mizutani; Sayaka Wakayama; Fumihito Miura; Takashi Ito; Tomohiro Kono, BIOLOGY OF REPRODUCTION, 94(6), 128-128, Jun. 2016
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  • Sex Specification and Heterogeneity of Primordial Germ Cells in Mice, Akihiko Sakashita; Yukiko Kawabata; Yuko Jincho; Shiun Tajima; Soichiro Kumamoto; Hisato Kobayashi; Yasuhisa Matsui; Tomohiro Kono, PLOS ONE, 10(12), e0144836, Dec. 2015
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  • Sunflower centromeres consist of a centromere-specific LINE and a chromosome-specific tandem repeat, Kiyotaka Nagaki; Keisuke Tanaka; Naoki Yamaji; Hisato Kobayashi; Minoru Murata, Frontiers in Plant Science, 6(OCTOBER), 912-912, 31 Oct. 2015
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  • Comprehensive DNA Methylation Analysis of Retrotransposons in Male Germ Cells, Ippei Nagamori; Hisato Kobayashi; Yusuke Shiromoto; Toru Nishimura; Satomi Kuramochi-Miyagawa; Tomohiro Kono; Toru Nakano, CELL REPORTS, 12(10), 1541-1547, Sep. 2015
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  • DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis, Naoki Kubo; Hidehiro Toh; Kenjiro Shirane; Takayuki Shirakawa; Hisato Kobayashi; Tetsuya Sato; Hidetoshi Sone; Yasuyuki Sato; Shin-ichi Tomizawa; Yoshinori Tsurusaki; Hiroki Shibata; Hirotomo Saitsu; Yutaka Suzuki; Naomichi Matsumoto; Mikita Suyama; Tomohiro Kono; Kazuyuki Ohbo; Hiroyuki Sasaki, BMC GENOMICS, 16, 624-624, Aug. 2015
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  • Genomic, epigenomic, and transcriptomic profiling towards identifying omics features and specific biomarkers that distinguish uterine leiomyosarcoma and leiomyoma at molecular levels., Miyata T; Sonoda K; Tomikawa J; Tayama C; Okamura K; Maehara K; Kobayashi H; Wake N; Kato K; Hata K; Nakabayashi K, Sarcoma Article ID 41268, 2015, 412068-412068, 2015
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  • Effect of feeding behavior on circadian regulation of endothelin expression in mouse colon, Takaharu Kozakai; Mitsue Sakate; Satoshi Takizawa; Tsuyoshi Uchide; Hisato Kobayashi; Katsutaka Oishi; Norio Ishida; Kaname Saida, LIFE SCIENCES, 118(2), 232-237, Nov. 2014
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  • Dynamics of genomic 5-hydroxymethylcytosine during mouse oocyte growth, Akihiko Sakashita; Hisato Kobayashi; Takuya Wakai; Yusuke Sotomaru; Kenichiro Hata; Tomohiro Kono, GENES TO CELLS, 19(8), 629-636, Aug. 2014
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  • Epigenetic and transcriptional features of the novel human imprinted lncRNA GPR1AS suggest it is a functional ortholog to mouse Zdbf2linc, Hisato Kobayashi; Eikichi Yanagisawa; Akihiko Sakashita; Naoko Sugawara; Shiori Kumakura; Hidehiko Ogawa; Hidenori Akutsu; Kenichiro Hata; Kazuhiko Nakabayashi; Tomohiro Kono, EPIGENETICS, 8(6), 635-645, Jun. 2013
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  • Mouse Oocyte Methylomes at Base Resolution Reveal Genome-Wide Accumulation of Non-CpG Methylation and Role of DNA Methyltransferases, Kenjiro Shirane; Hidehiro Toh; Hisato Kobayashi; Fumihito Miura; Hatsune Chiba; Takashi Ito; Tomohiro Kono; Hiroyuki Sasaki, PLoS Genetics, 9(4), e1003439-e1003439, 18 Apr. 2013
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  • High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice, Hisato Kobayashi; Takayuki Sakurai; Fumihito Miura; Misaki Imai; Kentaro Mochiduki; Eikichi Yanagisawa; Akihiko Sakashita; Takuya Wakai; Yutaka Suzuki; Takashi Ito; Yasuhisa Matsui; Tomohiro Kono, GENOME RESEARCH, 23(4), 616-627, Apr. 2013
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  • Imprinted DNA methylation reprogramming during early mouse embryogenesis at the Gpr1-Zdbf2 locus is linked to long cis-intergenic transcription, Hisato Kobayashi; Takayuki Sakurai; Shun Sato; Kazuhiko Nakabayashi; Kenichiro Hata; Tomohiro Kono, FEBS LETTERS, 586(6), 827-833, Mar. 2012
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  • Contribution of Intragenic DNA Methylation in Mouse Gametic DNA Methylomes to Establish Oocyte-Specific Heritable Marks, Hisato Kobayashi; Takayuki Sakurai; Misaki Imai; Nozomi Takahashi; Atsushi Fukuda; Obata Yayoi; Shun Sato; Kazuhiko Nakabayashi; Kenichiro Hata; Yusuke Sotomaru; Yutaka Suzuki; Tomohiro Kono, PLOS GENETICS, 8(1), Jan. 2012
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  • DNA methylation analysis of germ cells by using bisulfite-based sequencing methods, Hisato Kobayashi; Tomohiro Kono, Methods in Molecular Biology, 825, 223-235, 2012
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  • Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks., Hisato Kobayashi; Takayuki Sakurai; Misaki Imai; Nozomi Takahashi; Atsushi Fukuda; Obata Yayoi; Shun Sato; Kazuhiko Nakabayashi; Kenichiro Hata; Yusuke Sotomaru; Yutaka Suzuki; Tomohiro Kono, PLoS genetics, 8(1), e1002440, Jan. 2012
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  • Dynamic stage-specific changes in imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes, Shin-ichi Tomizawa; Hisato Kobayashi; Toshiaki Watanabe; Simon Andrews; Kenichiro Hata; Gavin Kelsey; Hiroyuki Sasaki, DEVELOPMENT, 138(5), 811-820, Mar. 2011
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  • DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm, Hisato Kobayashi; Hitoshi Hiura; Rosalind M. John; Akiko Sato; Eiko Otsu; Naoko Kobayashi; Rei Suzuki; Fumihiko Suzuki; Chika Hayashi; Takafumi Utsunomiya; Nobuo Yaegashi; Takahiro Arima, EUROPEAN JOURNAL OF HUMAN GENETICS, 17(12), 1582-1591, Dec. 2009
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  • Identification of the mouse paternally expressed imprinted gene Zdbf2 on chromosome 1 and its imprinted human homolog ZDBF2 on chromosome 2, Hisato Kobayashi; Kaori Yamada; Shinnosuke Morita; Hitoshi Hiura; Atsushi Fukuda; Masayo Kagami; Tsutomu Ogata; Kenichiro Hata; Yusuke Sotomaru; Tomohiro Kono, GENOMICS, 93(5), 461-472, May 2009
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  • Correlation between Shh expression and DNA methylation status of the limb-specific Shh enhancer region during limb regeneration in amphibians, Nayuta Yakushiji; Makoto Suzuki; Akira Satoh; Tomoko Sagai; Toshihiko Shiroishi; Hisato Kobayashi; Hiroyuki Sasaki; Hiroyuki Ide; Koji Tamura, DEVELOPMENTAL BIOLOGY, 312(1), 171-182, Dec. 2007
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  • Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients, Hisato Kobayashi; Akiko Sato; Eiko Otsu; Hitoshi Hiura; Chisako Tomatsu; Takafumi Utsunomiya; Hiroyuki Sasaki; Nobuo Yaegashi; Takahiro Arima, HUMAN MOLECULAR GENETICS, 16(21), 2542-2551, Nov. 2007
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  • Bisulfite sequencing and dinucleotide content analysis of 15 imprinted mouse differentially methylated regions (DMRs): paternally methylated DMRs contain less CpGs than maternally methylated DMRs, H Kobayashi; C Suda; T Abe; Y Kohara; T Ikemura; H Sasaki, CYTOGENETIC AND GENOME RESEARCH, 113(1-4), 130-137, 2006
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  • Effect of feeding on peripheral circadian rhythms and behaviour in mammals, H Kobayashi; K Oishi; S Hanai; N Ishida, GENES TO CELLS, 9(9), 857-864, Sep. 2004
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  • Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes, K Oishi; K Miyazaki; K Kadota; R Kikuno; T Nagase; G Atsumi; N Ohkura; T Azama; M Mesaki; S Yukimasa; H Kobayashi; C Iitaka; T Umehara; M Horikoshi; T Kudo; Y Shimizu; M Yano; M Monden; K Machida; J Matsuda; S Horie; T Todo; N Ishida, JOURNAL OF BIOLOGICAL CHEMISTRY, 278(42), 41519-41527, Oct. 2003
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  • Sex difference in circadian period of body temperature in Clock mutant mice with Jcl/ICR background, M Ochi; S Sono; H Sei; K Oishi; H Kobayashi; Y Morita; N Ishida, NEUROSCIENCE LETTERS, 347(3), 163-166, Aug. 2003
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  • Differential expressions of mPerl and mPer2 mRNAs under a skeleton photoperiod and a complete light-dark cycle, K Oishi; H Fukui; K Sakamoto; K Miyazaki; H Kobayashi; N Ishida, MOLECULAR BRAIN RESEARCH, 109(1-2), 11-17, Dec. 2002
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MISC

  • 受精後に再活性化するLTRレトロトランスポゾンによる種特異的インプリンティング遺伝子の確立, 小林久人, 日本分子生物学会年会プログラム・要旨集(Web), 47th, 2024
  • 内在性レトロトランスポゾンがゲノムインプリント機構の種特異的な進化を促す, 小林 久人; Bogutz Aaron B.; Brind'Amour Julie; Jensen Kristoffer N.; 中林 一彦; 今井 啓雄; Lorinczc Matthew; Lefebvre Louis, The Journal of Reproduction and Development, 65(Suppl.), j137-j137, Sep. 2019
  • Pregnancy-specific expression of IFIT1 in the bovine external uterine mucosa, ASAOKA Natsuki; KIMURA Koji; TAKAHASHI Masashi; KUNII Hiroki; KOYAMA Keisuke; KUBO Tomoaki; HAMAGUCHI Yu; OGAWA Hidehiko; KOBAYASHI Hisato; BAI Hanako; KAWAHARA Manabu, The Journal of Reproduction and Development Supplement, 112(0), P-71-P-71, 2019
    DOI
  • コムギのアブシシン酸受容体過剰発現による光合成速度の促進, 妻鹿良亮; 安倍史高; KIM June-sik; 田中啓介; 小林久人; 坂田洋一; 辻本壽; 岡本昌憲, 植物の生長調節, 54(Supplement), 2019
  • Comparisons of human, rat and mouse oocyte DNA methylomes, KOBAYASHI Hisato; LORINCZ Matthew C; AMOUR Julie Brind; ALBERT Julien Richard; SHIRANE Kenjiro; SAKASHITA Akihiko; KAMIO Asuka; KARIMI Mohammad M; LEFEBVRE Louis; KONO Tomohiro, The Journal of Reproduction and Development Supplement, 111(0), OR1-26-OR1-26, 2018
  • 節水型耐乾性を獲得したコムギは限られた水でも種子の品質を維持する, 妻鹿良亮; 安倍史高; 菊地淳; KIM J; 田中啓介; 小林久人; 坂田洋一; 辻本壽; 花田耕介; 岡本昌憲; 岡本昌憲; 岡本昌憲, 育種学研究, 19, 68, 07 Oct. 2017
  • Sex differences of histone modifications in mouse PGCs after erasure of DNA methylation, T. Kono; M. Kawabata; A. Kamio; Y. Jincho; T. Takashima; H. Kobayashi; Y. Matsui, HUMAN REPRODUCTION, 32, 113-114, Jul. 2017
  • マウス胚発生過程における片親性DNAメチル化の継承とリプログラミングの全容解明, 小林久人; 小池佐; 坂下陽彦; 隈本宗一郎; 神尾明日香; 河野友宏, エピゲノムはどこまで操れるようになったか 第11回日本エピジェネティクス研究会年会プログラム集 理研シンポジウム 平成29年, 2017
  • アブシジン酸受容体の強化はコムギの節水型耐乾性の形質を付与する, 妻鹿良亮; 安倍史高; KIM June‐sik; 田中啓介; 小林久人; 坂田洋一; 辻本壽; 花田耕介; 岡本昌憲; 岡本昌憲, 植物の生長調節, 51(Supplement), 29, 07 Oct. 2016
  • ABAシグナリング経路の強化によってもたらされるコムギの節水型乾燥ストレス耐性, 妻鹿良亮; 安倍史高; KIM J; 田中啓介; 小林久人; 坂田洋一; 辻本壽; 花田耕介; 岡本昌憲; 岡本昌憲, 育種学研究, 18, 27, 24 Sep. 2016
    DOI
  • ABAシグナリング経路の強化によってもたらされるコムギの節水型乾燥ストレス耐性, 妻鹿良亮; 安倍史高; KIM J; 田中啓介; 小林久人; 坂田洋一; 辻本壽; 花田耕介; 岡本昌憲; 岡本昌憲, 育種学研究, 18, 195, 21 Mar. 2016
  • 脱メチル化完了後のマウス始原生殖細胞におけるヒストン修飾の役割, 川畑順子; 神尾明日香; 神長祐子; 高島友弥; 坂下陽彦; 小林久人; 河野友宏; 河野友宏, 日本分子生物学会年会プログラム・要旨集(Web), 39th, 2016
  • MaxのDNAメチル化およびH3K9me2/3を介した生殖細胞関連遺伝子抑制機構, 辰巳大気; 林陽平; 遠藤舞; 小林久人; 河野友宏; 立花誠; 松居靖久, 日本分子生物学会年会プログラム・要旨集(Web), 39th, 2016
  • 小規模およびシングルセルショットガンバイサルファイトシーケンス解析による生殖細胞系列における反復配列特性の解明, 小林久人; 小池佐; 坂下陽彦; 田中啓介; 隈本宗一郎; 河野友宏, Journal of Reproduction and Development, 62(Suppl Japanese Issue), 2016
  • Sequential grievous disorders in Sry mutated XY oocytes throughout gametogenesis lead to reducing oocyte reserve and infertility, SAKASHITA Akihiko; NISHIMURA Chiaki; KOBAYASHI Hisato; SOTOMARU Yusuke; KONO Tomohiro, The Journal of Reproduction and Development Supplement, 109(0), OR1-25-OR1-25, 2016
  • Analysis of epigenetic marks on plant chromosomes -from micro to macro-, Kiyotaka Nagaki; Naoki Yamaji; Keisuke Tanaka; Hisato Kobayashi; Minoru Murata, GENES & GENETIC SYSTEMS, 90(6), 374-374, Dec. 2015
  • 新生仔マウスの精原幹細胞の形成と分化における全ゲノムDNAメチル化およびトランスクリプトーム解析, 久保 直樹; 藤 英博; 白根 健次郎; 白川 峰征; 小林 久人; 佐藤 哲也; 曾根 秀利; 佐藤 康人; 富澤 信一; 鶴崎 美徳; 柴田 弘紀; 才津 浩智; 鈴木 穣; 松本 直通; 須山 幹太; 河野 友宏; 大保 和之; 佐々木 裕之, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [1P0606]-[1P0606], Dec. 2015
  • 体細胞クローンマウス精子のDNAメチル化異常の検出, 小池佐; 神長祐子; 若井拓也; 若井拓也; 水谷英二; 小林久人; 若山清香; 坂下陽彦; 三浦史仁; 伊藤隆司; 河野友宏, J Reprod Dev, 61(Suppl Japanese Issue), J151-82-P-82, Sep. 2015
    DOI
  • Development of a novel method for identifying centromeric DNA sequences, Kiyotaka Nagaki; Keisuke Tanaka; Ryo Matsushima; Hisato Kobayashi; Minoru Murata, GENES & GENETIC SYSTEMS, 89(6), 304-304, Dec. 2014
  • 体細胞クローンマウス精子のDNAメチレーションエラー, 河野友宏; 若井拓哉; 水谷英二; 小林久人; 若山清香; 坂下陽彦; 三浦史仁; 伊藤隆司, J Reprod Dev, 60(Suppl Japanese Issue), J75-25-OR1-25, 10 Aug. 2014
    DOI
  • 網羅的遺伝子発現解析による加齢が卵丘細胞に与える影響の探索, 岸 靖典; 川原 玲香; 松井 大輔; 齊藤 隆和; 小林 久人; 河野 友宏; 齊藤 英和, Journal of Mammalian Ova Research, 31(2), S112-S112, Apr. 2014
  • マウス初期胚における5hmCおよびH3K9me2の挙動とDNA脱メチル化制御機構, 坂下陽彦; 中島芽生; 若井拓哉; 小林久人; 井関陽介; 河野友宏, Journal of Mammalian Ova Research, 31(2), S78-S78, 01 Apr. 2014
  • 食餌行動がマウス大腸のエンドセリン発現の日周制御に及ぼす影響, 小酒井貴晴; 小酒井貴晴; 坂手光恵; 滝澤聡; 打出毅; 小林久人; 大石勝隆; 石田直理雄; 石田直理雄; 斉田要; 斉田要, 日本分子生物学会年会プログラム・要旨集(Web), 37th, 2014
  • マウス生殖細胞・初期胚のDNAメチローム解析, 小林久人; 坂下陽彦; 若井拓哉; 小池佐; 佐野賢; 河野友宏, 日本分子生物学会年会プログラム・要旨集(Web), 37th, 2W6-5(2P-0005) (WEB ONLY), 2014
  • 体細胞クローンマウス精子のDNAメチル化リプログラミング, 若井拓哉; 水谷英二; 小林久人; 若山清香; 坂下陽彦; 伊藤隆司; 三浦史仁; 河野友宏, 日本分子生物学会年会プログラム・要旨集(Web), 37th, 3W8-6(3P-0172) (WEB ONLY), 2014
  • マウス卵子形成過程における5ヒドロキシメチル化シトシンのダイナミクス, 坂下陽彦; 小林久人; 井関陽介; 若井拓哉; 外丸祐介; 河野友宏, Journal of Reproduction and Development, 59(Suppl Japanese Issue), J77-j77, 20 Aug. 2013
    DOI
  • マウス卵子形成過程における5‐hydroxymethylcytosineのダイナミクス, 坂下陽彦; 小林久人; 井関陽介; 若井拓哉; 外丸祐介; 河野友宏, 日本分子生物学会年会プログラム・要旨集(Web), 36th, 2P-0679 (WEB ONLY), 2013
  • マウス始原生殖細胞におけるDNAメチローム解析, 小林久人; 櫻井隆順; 三浦史仁; 今井美咲; 望月研太郎; 柳澤永吉; 坂下陽彦; 若井拓哉; 鈴木穣; 伊藤隆司; 松居靖久; 河野友宏, Journal of Reproduction and Development, 58(Suppl Japanese Issue), J102-j102, 20 Aug. 2012
  • Screening for novel paternally methylated imprinted region in mouse genome, SAKASHITA Akihiko; KOBAYASHI Hisato; OBATA Yayoi; OGAWA Hidehiko; KONO Tomohiro, Journal of mammalian ova research = 日本哺乳動物卵子学会誌, 29(2), S56, 01 Apr. 2012
  • メチローム解析によるマウス卵子におけるnon-CpGメチル化責任酵素の同定, 白根健次郎; 白根健次郎; 藤英博; 小林久人; 三浦史仁; 伊藤隆司; 河野友宏; 佐々木裕之; 佐々木裕之, 日本分子生物学会年会プログラム・要旨集(Web), 35th, 2012
  • マウス始原生殖細胞におけるDNAメチローム解析, 小林久人; 櫻井隆順; 三浦史仁; 今井美咲; 望月研太郎; 柳澤永吉; 坂下陽彦; 若井拓哉; 鈴木穣; 伊藤隆司; 松居靖久; 河野友宏, 日本分子生物学会年会プログラム・要旨集(Web), 35th, 1W1I-5 (WEB ONLY), 2012
  • マウス配偶子における全ゲノム包括的DNAメチル化解析, 小林 久人; 櫻井 隆順; 高橋 望; 福田 篤; 尾畑 やよい; 佐藤 俊; 中林 一彦; 秦 健一郎; 外丸 佑介; 鈴木 穣; 河野 友宏, The Journal of Reproduction and Development, 57(Suppl.), j110-j110, Aug. 2011
  • The normality validation of the oocytes with epigenome (DNA methylome) analysis, KOBAYASHI Hisato, Journal of mammalian ova research = 日本哺乳動物卵子学会誌, 28(2), S14, 01 Apr. 2011
  • 単為発生胚を用いた新規インプリント遺伝子の探索 マウス1番染色体のZdbf2遺伝子は父由来アレル特異的に発現するインプリント遺伝子である, 小林 久人; 山田 かおり; 森田 慎之介; 樋浦 仁; 福田 篤; 鏡 雅代; 緒方 勤; 外丸 祐介; 河野 友宏, The Journal of Reproduction and Development, 54(Suppl.), j49-j49, Aug. 2008
  • Identification of Novel Mouse Imprinted Gene, Zdbf2, on Chromosome 1 by Microarray-based Screening Using Parthenogenetic Embryos, Kobayashi Hisato; Yamada Kaori; Morita Shinnosuke; Hiura Hitoshi; Fukuda Atsushi; Kagami Masayo; Ogata Tsutomu; Sotomaru Yusuke; Kono Tomohiro, JRD Supplement, 101(0), 16-16, 2008
  • クローズアップ実験法 170 バイサルファイト法によるDNAメチル化解析の落とし穴, 佐々木裕之; 熊木健治; 小林久人; 加藤譲; 平澤竜太郎, 実験医学, 25(14), 2191-2196, 01 Sep. 2007
  • Genomic Imprinting in Mammals, Hisato Kobayashi; Takahiro Arima, Journal of Mammalian Ova Research, 23(4), 143-149, 2006
    DOI
  • Increase of hippocampal acetylcholine release at the onset of dark phase is suppressed in a mutant mice model of evening-type individuals, H Sei; A Sano; K Oishi; H Fujihara; H Kobayashi; N Ishida; Y Morita, NEUROSCIENCE, 117(4), 785-789, 2003
    DOI
  • Skeleton photoperiod リズム同調における CLOCK 分子の役割, 大石 勝隆; 福井 広美; 坂本 克彦; 宮崎 歴; 小林 久人; 石田 直理雄, 日本時間生物学会会誌: Journal of Chronobiology, 6(2), 114-114, 01 Oct. 2000

Presentations

  • 種特異的インプリンティング遺伝子の確立における内在性レトロトランスポゾンの役割, 小林久人, 第47回日本分子生物学会大会 シンポジウム「ゲノム刷り込み機構の再定義と実例：エピゲノム制御機構の進化とコンフリクト仮説」, 28 Nov. 2024, 27 Nov. 2024, 29 Nov. 2024, Public symposium
  • Evolution of genomic imprinting via lineage-specific insertion of retroviral promoters, Hisato Kobayashi, 第46回日本分子生物学会大会 シンポジウム1AS-16「内在性ウイルスエレメント：その叡智をここに集約せよ！」, 06 Dec. 2023, 06 Dec. 2023, 08 Dec. 2023, Oral presentation
  • Interspecies comparison of an LTR-initiated transcript is illuminating the origin of ZDBF2 imprinting, Hisato Kobayashi, 第116回日本繁殖生物学会大会, 27 Sep. 2023, 24 Sep. 2023, 27 Sep. 2023, Oral presentation
  • マウス・ラット間におけるカノニカル・非カノニカル型刷り込み機構の保存性と多様性, 小林 久人, 第45回日本分子生物学会大会 ワークショップ3AW-07“ゲノム刷り込み研究から紐解くエピゲノム遺伝の新たなパラダイム”, 02 Dec. 2022, 30 Nov. 2022, 02 Dec. 2022, Oral presentation
  • ラットのゲノムワイドなインプリントーム解析, 小林 久人, 第115回日本繁殖生物学会大会, 13 Sep. 2022, 11 Sep. 2022, 14 Sep. 2022, Oral presentation
  • 「ゲノム・オタク」が見た繁殖生物学の過去と現在、そして未来, 小林 久人, 第114回日本繁殖生物学会大会 市民公開講座 "小中高生に届けたい、繁殖生物学オタクが今夢中になっていること", 23 Sep. 2021, Nominated symposium
  • Evolution and diversity of genomic imprinting via lineage-specific insertion of retroviral promoters, Hisato Kobayashi; Aaron; B. Bogutz; Julie Brind’Amour; Kristoffer N. Jensen; Kazuhiko Nakabayashi; Hiroo Imai; Matthew Lorincz; Louis Lefebvre, MBSJ 2019, 03 Dec. 2019, 03 Dec. 2019, 06 Dec. 2019, Nominated symposium, Japan
  • ヒト・ラット,マウス卵子のDNAメチローム比較解析, 小林久人; BRIND’AMOUR Julie; ALBERT Julien Richard; 白根健次郎; 坂下陽彦; 神尾明日香; KARIMI Mohammad M; LEFEBVRE Louis; 河野友宏; LORINCZ Matthew C, 第111回日本繁殖生物学会大会, 15 Sep. 2018, 12 Sep. 2018, 16 Sep. 2018, Oral presentation, False
  • Active endogenous retroviruses drive species-specific changes in the mammalian oocyte methylome, Hisato Kobayashi; Julie Brind’Amour; Julien Richard Albert; Kenjiro Shirane; Akihiko Sakashita; Asuka Kamio; Mohammad Karimi; Louis Lefebvre; Tomohiro Kono; Matthew Lorincz, 第12回日本エピジェネティクス研究会年会, 24 May 2018, 24 May 2018, 24 May 2018, Oral presentation, False
  • マウスのゲノム包括的なアレル特異的DNAメチローム解析, 小林 久人, 第5回NGS現場の会, 24 May 2017, 22 May 2017, 24 May 2017, Invited oral presentation, False
  • DNA methylome analysis in mouse germ cells and early embryos, Hisato Kobayashi, Genomic Imprinting, Epigenetics, and Physiological Functions, 02 Oct. 2016, 02 Oct. 2016, 07 Oct. 2016, Oral presentation, True
  • ゲノミックインプリンティング～全ゲノムバイサルファイトシーケンス解析から“目印”として働くDNAメチル化の本質を探る～, 小林 久人, 第５回生命医薬情報学連合大会, 29 Sep. 2016, Invited oral presentation, False
  • Repetitive DNA methylome analysis by small-scale and single cell shotgun bisulfite sequencing, 小林久人; 小池佐; 坂下陽彦; 田中啓介; 河野友宏, BMB2015, 02 Dec. 2015, 01 Dec. 2015, 04 Dec. 2015, Oral presentation
  • 次世代シーケンサーを利用した新しい農学研究分野の開拓, 小林 久人, 日本動物遺伝育種学会第16回大会, 08 Nov. 2015, Invited oral presentation, False
  • 小規模ショットガンバイサルファイトシーケンス解析による生殖細胞系列における反復配列特性の解明, 小林久人; 小池佐; 坂下陽彦; 田中啓介; 河野友宏, 第108回日本繁殖生物学会大会, 19 Sep. 2015, 16 Sep. 2015, 20 Sep. 2015, Oral presentation
  • High-resolution DNA methylome analysis of mouse germ cells, Hisato Kobayashi, World Congress of Reproductive Biology 2014, 02 Sep. 2014, 02 Sep. 2014, 04 Sep. 2014, Invited oral presentation, True
  • マウス生殖細胞・初期胚のDNAメチローム解析, 小林久人; 坂下陽彦; 若井拓哉; 小池佐; 佐野賢; 河野友宏, 日本分子生物学会年会プログラム・要旨集(Web), 2014
  • マウス卵子形成過程における5ヒドロキシメチル化シトシンのダイナミクス, 坂下陽彦; 小林久人; 井関陽介; 若井拓哉; 外丸祐介; 河野友宏, J Reprod Dev, 20 Aug. 2013
  • 刷り込み遺伝子クラスター領域GPR1‐ZDBF2におけるlncRNAを介したエピジェネティクス制御機構とヒト・マウスゲノム間の保存性, 小林久人; 柳澤永吉; 坂下陽彦; 菅原直子; 熊倉紫織; 小川英彦; 阿久津英憲; 秦健一郎; 中林一彦; 河野友宏, 日本分子生物学会年会プログラム・要旨集(Web), 2013
  • マウス卵子形成過程における5‐hydroxymethylcytosineのダイナミクス, 坂下陽彦; 小林久人; 井関陽介; 若井拓哉; 外丸祐介; 河野友宏, 日本分子生物学会年会プログラム・要旨集(Web), 2013
  • マウス始原生殖細胞におけるDNAメチローム解析, 小林久人; 櫻井隆順; 三浦史仁; 今井美咲; 望月研太郎; 柳澤永吉; 坂下陽彦; 若井拓哉; 鈴木穣; 伊藤隆司; 松居靖久; 河野友宏, J Reprod Dev, 20 Aug. 2012
  • マウスにおける新規父方特異的メチル化DNA領域の探索, 坂下陽彦; 小林久人; 尾畑やよい; 小川英彦; 河野友宏, J Mamm Ova Res, 01 Apr. 2012
  • メチローム解析によるマウス卵子におけるnon‐CpGメチル化責任酵素の同定, 白根健次郎; 藤英博; 小林久人; 三浦史仁; 伊藤隆司; 河野友宏; 佐々木裕之, 日本分子生物学会年会プログラム・要旨集(Web), 2012
  • マウス始原生殖細胞におけるDNAメチローム解析, 小林久人; 櫻井隆順; 三浦史仁; 今井美咲; 望月研太郎; 柳澤永吉; 坂下陽彦; 若井拓哉; 鈴木穣; 伊藤隆司; 松居靖久; 河野友宏, 日本分子生物学会年会プログラム・要旨集(Web), 2012
  • Contribution of Intragenic DNA Methylation in Mouse Gametic DNA Methylomes to Establish Oocyte-Specific Heritable Marks,, Hisato Kobayashi, World Congress on Reproductive Biology 2011, Oct. 2011, Oral presentation, True
  • マウス配偶子における全ゲノム包括的DNAメチル化解析, 小林久人; 櫻井隆順; 高橋望; 福田篤; 尾畑やよい; 佐藤俊; 中林一彦; 秦健一郎; 外丸佑介; 鈴木穣; 河野友宏, J Reprod Dev, 20 Aug. 2011
  • マウス始原生殖細胞の包括的DNAメチル化解析, 櫻井隆順; 小林久人; 松居靖久; 河野友宏, J Reprod Dev, 20 Aug. 2011
  • エピゲノム解析(DNAメチローム解析)による卵子正常性の評価, 小林久人, J Mamm Ova Res, 01 Apr. 2011
  • マウス配偶子における全ゲノム包括的DNAメチローム解析, 小林久人; 櫻井隆順; 今井美咲; 高橋望; 福田篤; 尾畑やよい; 佐藤俊; 中林一彦; 秦健一郎; 外丸佑介; 鈴木穣; 河野友宏, 日本分子生物学会年会プログラム・要旨集(Web), 2011
  • Methylomes and transcriptomes in mouse germ cells, Tomohiro Kono; Hisato Kobayashi; Yutaka Suzuki, International Symposium on “Epigenome Network, Development and Reprogramming of Germ Cells”, Nov. 2010, Invited oral presentation, True
  • 新規インプリント遺伝子Zdbf2発現制御機構の解明, 櫻井隆順; 小林久人; 秦健一郎; 河野友宏, J Reprod Dev, 20 Aug. 2010
  • Bisulphite Shotgun Sequencing法によるマウス生殖細胞の包括的DNAメチル化解析, 小林久人; 桜井隆順; 福田篤; 高橋望; 尾畑やよい; 中林一彦; 秦健一郎; 外丸佑介; 鈴木穣; 河野友宏, 生化学, 2010
  • 単為発生胚を用いた新規インプリント遺伝子の探索:マウス1番染色体のZdbf2遺伝子は父由来アレル特異的に発現するインプリント遺伝子である, 小林久人; 山田かおり; 森田慎之介; 樋浦仁; 福田篤; 鏡雅代; 緒方勤; 外丸祐介; 河野友宏, J Reprod Dev, 25 Aug. 2008
  • マウス生殖細胞におけるインプリント領域のDNAメチル化解析, 富澤信一; 小林久人; 渡部聡朗; 堀池浩子; 佐々木裕之, 生化学, 2008
  • 単為発生胚を用いた新規インプリント遺伝子の探索:マウス1番染色体のZdbf2遺伝子は父由来アレル特異的に発現するインプリント遺伝子である, 小林久人; 山田かおり; 森田慎之介; 樋浦仁; 福田篤; 鏡雅代; 緒方勤; 外丸祐介; 河野友宏, 生化学, 2008
  • 両生類における四肢再生の鍵となるShh発現のエピジェネティクス制御, 薬師寺那由他; 嵯峨井知子; 城石俊彦; 小林久人; 佐々木裕之; 井出宏之; 田村宏治, 日本動物学会大会要旨集, 31 Aug. 2007
  • 男性不妊症の精子におけるインプリント異常, 小林久人; 佐藤晶子; 大津英子; 樋浦仁; 戸松千紗子; 宇都宮隆史; 佐々木裕之; 八重樫伸生; 有馬隆博, 生化学, 2007
  • Xenopus成体肢再生時の不完全な前後軸形成におけるエピジェネティックとジェネティックなカスケード(原標題は英語), 藥師寺那由他; 鈴木誠; 佐藤伸; 嵯峨井知子; 城石俊彦; 小林久人; 佐々木裕之; 竹島一仁; 井出宏之; 田村宏治, 日本発生生物学会大会発表要旨集, May 2006
  • Genomic Imprinting in Mammals, Hisato Kobayashi; Takahiro Arima, Journal of Mammalian Ova Research, 01 Jan. 2006, Genomic imprinting describes the epigenetic phenomenon is that the parent's origin is marked on genome. The phenomenon is unique to placental mammals, and causes parent-of-origin-specific monoallelic expression of most of imprinted genes. The previous studies on mice clarified that these gene expression control required the sex-specific differences of DNA methylation which were established in oogenesis or spermatogenesis. In this paper, we review the relevance of genomic imprinting mechanism and DNA methylation. © 2006, JAPANESE SOCIETY OF OVA RESEARCH. All rights reserved.
  • マウスインプリンティング遺伝子のDMRに共通な特徴の探索, 小林久人; 阿部貴志; 小原雄治; 小原雄治; 池村淑道; 佐々木裕之, 日本分子生物学会年会講演要旨集, 25 Nov. 2005
  • マウスインプリンティング遺伝子のDMRに共通な特徴の探索, 小林久人; 阿部貴志; 池村淑道; 佐々木裕之, 日本分子生物学会年会プログラム・講演要旨集, 25 Nov. 2004
  • 時計遺伝子変異マウスにおけるPAI‐1 mRNAの日周発現, 大石勝隆; 小林久人; 石田直理雄; 堀江修一; 松田重三, 日本血栓止血学会誌, 01 Oct. 2002
  • Skeleton photoperiodリズム同調におけるCLOCK分子の役割, 大石勝隆; 福井広美; 坂本克彦; 宮崎歴; 小林久人; 石田直理雄, 日本時間生物学会会誌, Oct. 2000

Industrial Property Rights

  • Patent right, 不妊症患者精子におけるインプリント異常発生リスクの判定方法, 有馬隆博, 小林久人, 特願2008-007343, 1- 2008, 東北大学, 特許2009-165409, 7- 2009, 東北大学, Domestic, Domestic
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Educational activity

Teaching Experience

  • 20 Apr. 2020, Embryology, Nara Medical University
  • 20 Apr. 2021, Bioinformatics, Kindai University
  • 20 Oct. 2014, 生命情報科学, Tokyo University of Agriculture, Undergraduate special subjects, Japan
  • 20 Oct. 2014, バイオインフォマティクス, Tokyo University of Agriculture, Undergraduate special subjects, Japan
  • 20 Apr. 2013, 基礎生物学実験（一）, Tokyo University of Agriculture, Undergraduate special subjects, Japan
  • 20 Oct. 2014, 分子栄養学実験, Tokyo University of Agriculture, Undergraduate special subjects, Japan
  • 20 Apr. 2013, バイオサイエンス専攻実験, Tokyo University of Agriculture, Undergraduate special subjects, Japan

Social contributions

Academic Contribution

  • Review, 01 Apr. 2019, 9999

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