YAZAWA HANAKO

Profiles

Profiles

• 氏名

  YAZAWA HANAKO

Affiliation

• Department of Pathology, Senior Assistant Professor

Profile and Settings

Research Areas

• Life Science, Experimental pathology
• Life Science, Respiratory medicine
• Life Science, Human pathology

Research Experience

• 01 Jul. 2017, 2023, Dokkyo Medical University School of Medicine, Dept. of Pathology, Lecturer
• Oct. 2006, Jul. 2017
• Apr. 2006, Sep. 2006

Research achievements

Awards

• 22 Mar. 2021, Author, Others, Japan

Published Papers

Original paper
• REST inactivation and coexpression of ASCL1 and POU3F4 are necessary for the complete transformation of RB1/TP53-inactivated lung adenocarcinoma into neuroendocrine carcinoma., Masawa M, Sato-Yazawa H, Kashiwagi K, Ishii J, Miyata-Hiramatsu C, Iwamoto M, Kohno K, Miyazawa T, Onozaki M, Noda S, Shimizu Y, Niho S, Yazawa T, Am J Pathol, 192(6), 857-861, 01 Jun. 2022

  DOI
• LXRβ activation inhibits proliferation of small cell lung cancer cells through depletion of cellular cholesterol, Kashiwagi K, Sato-Yazawa H, Ishii J, Kohno K, Tatsuka I, Miyazawa T, Takagi M, Chiba H, Yazawa T., Anticancer Research, Jun. 2022
• Endocrine secretory granule production is caused by a lack of REST and intragranular secretory content and accelerated by PROX1., Ishii J, Sato-Yazawa H, Kashiwagi K, Nakadate K, Iwamoto M, Kohno K, Miyata-Hiramatsu C, Masawa M, Onozaki M, Noda S, Miyazawa T, Takagi M, Yazawa T., J Mol Histol, 53, 437-448, May 2022
• Utility of a Single Particle Isolation System in Genome-editing and Gene-transfection Experiments, Hanako Sato-Yazawa, Korehito Kashiwagi, Jun Ishii, Meitetsu Masawa, Masato Onozaki, Chie Miyata-Hiramatsu, Tadasuke Miyazawa, Mai Sakaguchi, Takuya Yazawa, Dokkyo Journal of Medical Sciences, Jul. 2021
• Histopathological evaluation of the effectiveness of oral Eppikajutsuto treatment for lymphatic malformation, Matsudera S, Sato-Yazawa H, Terada M, Yamaguchi T, Tani Y, Watanabe S, Kashiwagi K, Ishii J, Ito Y, Ogino K, Okamoto K, Nakajima M, Morita S, Yamaguchi S, Kuroda H, Tsuchioka T, Kojima K, Yazawa T, J Pediatr Surg, 2021
• Adenovirus vector expressing keratinocyte growth factor using CAG promoter impairs pulmonary function of mice with elastase-induced emphysema., Oki H, Yazawa T, Baba Y, Kanegae Y, Sato H, Sakamoto S, Goto T, Saito I, Kurahashi K., Microbiology and immunology, 61(7), 264-271, Jul. 2017

  DOI
• PROX1 promotes secretory granule formation in medullary thyroid cancer cells., Ishii J, Yazawa T, Chiba T, Shishido-Hara Y, Arimasu Y, Sato H, Kamma H., Endocrinology, 157(3), 1289-1298, Mar. 2016

  DOI
• Class III/IV POU transcription factors expressed in small cell lung cancer cells are involved in proneural/neuroendocrine differentiation., Ishii J, Sato H (JI and HS are equally contributed), Yazawa T, Shishido-Hara Y, Hiramatsu C, Nakatani Y, Kamma H., Pathology International, 64(9), 415-422, Sep. 2014

  DOI
• Expression of developing neural transcription factors in lung carcinoid tumors., Endo T, Yazawa T Shishido-Hara Y, Fujiwara M, Shimoyamada H, Ishii J, Sato H, Tachibana K, Takei H, Kondo H, Goya T, Endo S, Kamma H., Pathology International, 64(8), 365-374, Aug. 2014

  DOI
• Neural lineage-specific homeoprotein BRN2 is directly involved in TTF1 expression in small-cell lung cancer., Sakaeda M, Sato H, Ishii J, Miyata C, Kamma H, Shishido-Hara Y, Shimoyamada H, Fujiwara M, Endo T, Tanaka R, Kondo H, Goya T, Aoki I, Yazawa T., Laboratory Investigation, 93(4), 408-421, Apr. 2013

  DOI
• POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1, and neuroendocrine marker molecules and cell growth in small cell lung cancer., Ishii J, Sato H, Sakaeda M, Shishido-Hara Y, Hiramatsu C, Kamma H, Shimoyamada H, Fujiwara M, Endo T, Aoki I, Yazawa T., Pathology International, 23(3), 158-168, Mar. 2013

  DOI
• Differences of molecular expression mechanisms among neural cell adhesion molecule 1, synaptophysin, and chromogranin A in lung cancer cells., Kashiwagi K, Ishii J, Sakaeda M, Arimasu Yuu, Shimoyamada H, Sato H, Miyata C, Kamma H, Aoki I, Yazawa T., Pathology International, 62(4), 232-245, Apr. 2012

  DOI
• Keratinocyte growth factor gene transduction ameliorates pulmonary fibrosis induced by bleomycin in mice., Sakamoto S, Yazawa T, Baba Y, Sato H, Kanegae Y, Hirai T, Saito I, Goto T, Kurahashi K., American Journal of Respiratory Cell and Molecular Biology, 45(3), 489-497, Sep. 2011

  DOI
• Insulin-like growth factor binding protein-4 gene silencing in lung adenocarcinomas., Sato H, Sakaeda M, Ishii J, Kashiwagi K, Shimoyamada H, Okudela K, Tajiri M, Ohmori T, Ogura T, Woo T, Masuda M, Hirata K, Kitamura H, Yazawa T ., Pathology International, 61(1), 19-27, Jan. 2011

  DOI
• Early growth response-1 induces and enhances vascular endothelial growth factor-A expression in lung cancer cells., Shimoyamada H, Yazawa T Sato H, Okudela K, Ishii J, Sakaeda M, Kashiwagi K, Suzuki T, Mitsui H, Woo T, Tajiri M, Ohmori T, Ogura T, Masuda M, Oshiro H, Kitamura H., American Journal of Pathology, 177(1), 70-83, Jan. 2010

  DOI
• Down-regulation of FXYD3 expression in human lung cancers. Its mechanism and potential role in carcinogenesis., Okudela K, Yazawa T, Ishii J, Woo T, Mitsui H, Bunai T, Sakaeda M, Shimoyamada H, Sato H, Tajiri M, Ogawa N, Masuda M, Sugimura H, Kitamura H., American Journal of Pathology, 175(6), 2646-2656, Dec. 2009

  DOI
• Neuroendocrine cancer-specific up-regulating mechanism of insulin-like growth factor binding protein-2 in small cell lung cancer., Yazawa T, Sato H, Shimoyamada H, Okudela K, Woo T, Tajiri M, Ogura T, Ogawa N, Suzuki T, Mitsui H, Ishii J, Miyata C, Sakaeda M, Goto K, Kashiwagi K, Masuda M, Takahashi T, Kitamura H., American Journal of Pathology, 175(3), 976-987, Sep. 2009

  DOI
• Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis., Okudela K, Yazawa T, Woo T, Sakaeda M, Ishii J, Matsui H, Shimoyamada H, Sato H, Tajiri M, Ogawa N, Masuda M, Takahashi T, Sugimura H, Kitamura H., American Journal of Pathology, 175(2), 886-881, Aug. 2009

  DOI
• Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia., Sato H, Yazawa T, Suzuki T, Shimoyamada H, Okudela K, Ikeda M, Hamada K, Yamada-Okabe H, Yao M, Kubota Y, Takahashi T, Kamma H, Kitamura H., American Journal of Pathology, 169(5), 1550-1566, Nov. 2006

  DOI
• Enhancement of pleural dissemination and lymph node metastasis of intrathoracic lung cancer cells by vascular endothelial growth factors (VEGFs)., Ishii H, Yazawa T, Sato H, Suzuki T, Ikeda M, Hayashi Y, Takanashi T, Kitamura H., Lung Cancer, 45(3), 325-337, Sep. 2004

  DOI
• K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via AKT activation., Okudela K, Hayashi H, Ito T, Yazawa T, Suzuki T, Nakane Y, Sato H, Ishii H, KeQin X, Masuda A, Takahashi T, Kitamura H., American Journal of Pathology, 164(1), 91-100, Jan. 2004

  DOI
• 31(4), 224-230, 2011
• 31(9), 628-635, 2011

Other
• Small cell lung cancer: significance of RB alterations and TTF-1 expression in its carcinogenesis, phenotype, and biology., Kitamura H, Yazawa T, Sato H, Okudela K, Shimoyamada H., Endocrine Pathology, 20(2), 101-107, 2009

  DOI
• Cancer stem cell: implications in cancer biology and therapy with special reference to lung cancer., Kitamura H, Okudela K, Yazawa T, Sato H, Shimoyamada H., Lung Cancer, 66(3), 275-281, Dec. 2009

  DOI
• Molecular and genetic pathogenesis of lung cancer: differences between small-cell and non-small-cell carcinomas., Kitamura H, Yazawa T, Okudela K, Shimoyamada H, Sato H., Open Pathology Journal, 2, 106-114, 2008

Books etc

• Joint work, Kenji Koizumi, Hanako Yazawa, Hajime Inoue, KENPAKUSHA, 01 Oct. 2022, 136
• Joint work, 2013, 48-105

Presentations

• RB1/TP53/REST-inactivated lung adenocarcinoma transforms into NEC by proneual factor expression, Hanako Yazawa, Korehito Kashiwagi, Jun Ishii, Kakeru Kono, Masato Onozaki, Shuhei Noda, Kodai Konno, Tadasuke Miyazawa, Takuya Yazawa, The 112th Annual Meeting of the Japanese Society of Pathology, 13 Apr. 2023, 13 Apr. 2023, 15 Apr. 2023, Oral presentation, Shimonoseki, Japan, False
• Hanako Yazawa, Korehito Kashiwagi, Jun Ishii, Kakeru Kono, Masato Onozaki Shuhei Noda, Kodai Konno, Tadasuke Miyazawa, Takuya Yazawa, The 26th Annual Meeting of the Japan Endocrine Pathology Society, 28 Oct. 2022, 28 Oct. 2022, 29 Oct. 2022, Oral presentation, Tokyo, Japan, False, Domestic journal
• Transcription factor analysis involved in Napsin A expression in ovarian clear cell carcinoma, Masami Iwamoto, Hanako Yazawa, Jun Ishii, Korehito Kashiwagi, Chie Hiramatsu, Takuya Yazawa, The 109th Annual Meeting of the Japanese Society of Pathology, 01 Jul. 2022, 01 Jul. 2022, 31 Jul. 2022, Oral presentation, Fukuoka, False, Domestic journal
• Different sensitivity to CDX2 among cultured lung adenocarcinoma cell lines, Riku Murai, Mai Sakaguchi, Hanako Yazawa, Chie Hiramatsu, Jun Ishii, Korehito Kashiwagi, Masami Iwamoto, Meitetsu Masawa, Takuya Yazawa, The 109th Annual Meeting of the Japanese Society of Pathology, 01 Jul. 2020, 01 Jul. 2020, 31 Jul. 2020, Poster presentation, Japan, False, Domestic journal
• Alteration of PROX1 / REST gene expression increases highly chromogranin-expressing cell population, Tadasuke Miyazawa, Jun Ishii, Hanako Yazawa, Korehito Kashiwagi, Masami Iwamoto, Meitetsu Masawa, Takuya Yazawa, The 109th Annual Meeting of the Japanese Society of Pathology, 01 Jul. 2020, 01 Jul. 2020, 31 Jul. 2020, Poster presentation, Fukuoka, Japan, False, Domestic journal
• Asuka Taniguchi, Mai Sakaguchi, Motokazu Eshima, Hanako Yazawa, Jun Ishii, Korehito Kashiwagi, Chie Hiramatsu, Takuya Yazawa, The 108th Annual Meeting of the Japanese Society of Pathology, 19 May 2019, 19 May 2019, 21 May 2019, Poster presentation, Tokyo, Japan, False, Domestic journal
• Isaaki Tatsuta, Tadasuke Miyazawa, Korehito Kashiwagi, Hanako Yazawa, Jun Ishii, Masami Iwamoto, Meitetsu Masawa, Masayuki Ota, Hideki Chiba, Takuya Yazawa, The 108th Annual Meeting of the Japanese Society of Pathology, 09 May 2019, 09 May 2019, 11 May 2019, Poster presentation, Tokyo, Japan, False, Domestic journal
• Direct reprogramming phenomenon caused by POU3F4/4F2 gene transfection in lung cancer cells., Yazawa H, Ishii J, Kashiwagi K, Shisido-Hara Y, Hiramatsu C, Kamma H, Yazawa T., Oct. 2017, Oral presentation, The 21st Annual Meeting of Japan Endocrine Pathology Society, False
• Direct reprogramming phenomenon caused by POU3F4/4F2 gene transfection in lung cancer cells., Sato H, Ishii J, Hiramatsu C, Shishido-Hara Y, Kamma H, Yazawa T., Apr. 2017, Oral presentation, The 106th Annual Meeting of the Japanese Society of Pathology, False
• Class III/IV POUtranscription factors expressed in small cell lung cancer cells are involved in proneural/neuroendocrine differentiation., Yazawa H, Hiramatsu C, Hirata K., Mar. 2015, Poster presentation, The 120th Annual Meeting of the Japanese Association of Anatomists, The 92nd Annual Meeting of the Physiological Society of Japan, False
• Effects of vascular endothelial growth factors (VEGFs) on biological behavior of intrathoracic lung cancer cells, Shimoyamada H, Sato H, Yazawa T, Okudela K, Kitamura H., Sep. 2007, Poster presentation, 12th World Conference on Lung Cancer, True
• Growth regulation via insulin-like growth factor binding protein-4 and -2 in lung epithelial cells and cancers., Sato H, Yazawa T, Shimoyamada Okudela K, Kitamura H., Sep. 2007, Poster presentation, 12th World Conference on Lung Cancer, True
• The immunological characteristic of a large cell neuroendocrine cancer cell line different from small cell lung cancer cell lines., Yazawa T, Kamma H, Endo K, Ito T, Ishii H, Sato H, Okudela K, Ogata T, Kanisawa M, Kitamura H., 2003, Poster presentation, 10th World Congress on Lung Cancer, True
• Significant upregulation of insulin-like growth factor binding protein-4 and ?2 by K-ras activation in pulmonary airway epithelial cells and cancers., Sato H, Yazawa T, Hamada K, Yamada-Okabe H, Okudela K, Ishii H, Ito T, Kanisawa M, Takahashi T, Kitamura H., 2003, Poster presentation, 10th World Congress on Lung Cancer, True
• Analysis of gene expression in cancer cells by DNA microarray technology., Ishiguro H, Sato H, Ikeda N, Uemura H, Kubota Y., Nov. 2000, Poster presentation, The 7th China-Japan Bilateral Symposium on Intelligent Electrophotonic Materials & molecular Electronics, True
• Study of the differential expression of genes by DNA microarray in the cells after ras genes transfection., Sato H, Ishiguro H, Ikeda N, Uemura H, Hosaka M, Kubota Y., Nov. 2000, Poster presentation, The 7th China-Japan Bilateral Symposium on Intelligent Electrophotonic Materials & molecular Electronics, True

Educational activity

Teaching Experience

• Apr. 2022, May 2022, Medical English III, Dokkyo Medical University School of Medicine, Undergraduate special subjects, Japan
• Apr. 2021, May 2021, Medical English III, Dokkyo Medical University School of Medicine, Undergraduate special subjects, Japan
• Apr. 2020, May 2020, Medical English III, Dokkyo Medical University School of Medicine, Undergraduate special subjects, Japan

Social contributions

Media Coverage

• Paper, Other than myself, 26 Mar. 2021
• Media report, Other than myself, 14 Mar. 2021

University administration

学内委員会等活動

• 2022
• 2022
• 2021
• 2020