KOJIMA HIDEFUMI

Profiles

Profiles

• 氏名

  KOJIMA HIDEFUMI

Affiliation

• Associate Professor

Research achievements

Published Papers

Original paper
• Fine-tuning of antigen-specific immune responses by regulatory T cells activated via antigen recognition-independent and humoral factor-dependent mechanisms., Kojima Hidefumi, Kashiwakura Yuji, Kanno Yumiko, Hashiguchi Masaaki, Kobata Tetsuj, Scandinavian journal of immunology, 04 Jan. 2021

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• Heparin affects the induction of regulatory T cells independent of anti-coagulant activity and suppresses allogeneic immune responses., Kashiwakura Y;Kojima H;Kanno Y;Hashiguchi M;Kobata T, Clinical and experimental immunology, 202(1), 119-135, 2020

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• 211, 53-59, Jul. 2019

  DOI
• 323, 41-48, 2017
• 197(10), 4014-4020, 2016
• 165(1), 1-9, 2015
• 45(3), 876-885, 2014
• 66, 373-382, 2014
• CD2-mediated regulation of peripheral CD4(+) CD25(+) regulatory T-cell apoptosis accompanied by down-regulation of Bim, Kashiwakura Y, Sakurai D, Kanno Y, Hashiguchi M, Kobayashi A, Kurosu A, Tokudome S, Kobata T, Kojima H, Immunology, 139(1), 48-60, May 2013

  DOI
• 2, 9-16, 2012
• Naive CD4+ T cells of Peyer's patches produce more IL-6 than those of spleen in response to antigenic stimulation, Hashiguchi M, Hachimura S, Ametani A, Sato T, Kojima H, Kumagai Y, Habu S, Kobata T, Kaminogawa S, Immunol Lett, 141(1), 109-115, Dec. 2011

  DOI
• Notch2 signaling is required for potent antitumor immunity in vivo, Sugimoto K, Maekawa Y, Kitamura A, Nishida J, Koyanagi A, Yagita H, Kojima H, Chiba S, Shimada M, Yasutomo K, J Immunol, 184(9), 4673-4678, May 2010

  DOI
• TACI induces cIAP1-mediated ubiquitination of NIK by TRAF2 and TANK to limit non-canonical NF-kappaB signaling, Kanno Y, Sakurai D, Hase H, Kojima H, Kobata T, J Recept Signal Transduct Res, 30(2), 121-132, Apr. 2010

  DOI
• Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow, Kojima H, Kobayashi A, Sakurai D, Kanno Y, Hase H, Takahashi R, Totsuka Y, Semenza GL, Sitkovsky MV, Kobata T, J Immunol, 184(1), 154-163, Jan. 2010

  DOI
• Coculture of osteoclast precursors with rheumatoid synovial fibroblasts induces osteoclastogenesis via transforming growth factor beta-mediated down-regulation of osteoprotegerin, Hase H, Kanno Y, Kojima H, Sakurai D, Kobata T, Arthritis Rheum, 58(11), 3356-3365, Nov. 2008

  DOI
• Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity, Maekawa Y, Minato Y, Ishifune C, Kurihara T, Kitamura A, Kojima H, Yagita H, Sakata-Yanagimoto M, Saito T, Taniuchi I, Chiba S, Sone S, Yasutomo K, Nat Immunol, 9(10), 1140-1147, Oct. 2008

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• TACI regulates IgA production by APRIL in collaboration with HSPG, Sakurai D, Hase H, Kanno Y, Kojima H, Okumura K, Kobata T, Blood, 109(7), 2961-2967, Apr. 2007

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• TACI attenuates antibody production costimulated by BAFF-R and CD40, Sakurai D, Kanno Y, Hase H, Kojima H, Okumura K, Kobata T, Eur J Immunol, 37(1), 110-118, Jan. 2007

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• Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes, Lukashev D, Klebanov B, Kojima H, Grinberg A, Ohta A, Berenfeld L, Wenger RH, Ohta A, Sitkovsky M, J Immunol, 177(8), 4962-4965, Oct. 2006
• Identification of a glioma antigen, GARC-1, using cytotoxic T lymphocytes induced by HSV cancer vaccine, Iizuka Y, Kojima H, Kobata T, Kawase T, Kawakami Y, Toda M, Int J Cancer, 118(4), 942-949, Feb. 2006

  DOI
• CD4+CD25+ regulatory T cells attenuate the phosphatidylinositol 3-kinase/Akt pathway in antigen-primed immature CD8+ CTLs during functional maturation, Kojima H, Kanno Y, Hase H, Kobata T, J Immunol, 174(10), 5959-5967, May 2005
• Essential role of OX40L on B cells in persistent alloantibody production following repeated alloimmunizations, Kato H, Kojima H, Ishii N, Hase H, Imai Y, Fujibayashi T, Sugamura K, Kobata T, J Clin Immunol, 24(3), 237-248, May 2004

  DOI
• BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex, Hase H, Kanno Y, Kojima M, Hasegawa K, Sakurai D, Kojima H, Tsuchiya N, Tokunaga K, Masawa N, Azuma M, Okumura K, Kobata T, Blood, 103(6), 2257-2265, Mar. 2004

  DOI
• Central role of mitochondria and p53 in Fas-mediated apoptosis of rheumatoid synovial fibroblasts, Itoh K, Hase H, Kojima H, Saotome K, Nishioka K, Kobata T, Rheumatology (Oxford), 43(3), 277-285, Mar. 2004

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• CD27 and CD40 inhibit p53-independent mitochondrial pathways in apoptosis of B cells induced by B cell receptor ligation, Hase H, Kanno Y, Kojima H, Morimoto C, Okumura K ,Kobata T, J Biol Chem, 277(49), 46950-46958, Dec. 2002

  DOI
• Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice, Kojima H, Gu H, Nomura S, Caldwell CC, Kobata T, Carmeliet P, Semenza GL, Sitkovsky MV, Proc Natl Acad Sci U S A, 99(4), 2170-2174, Feb. 2002

  DOI
• Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions, Caldwell CC, Kojima H, Lukashev D, Armstrong J, Farber M, Apasov SG, Sitkovsky MV, J Immunol, 167(11), 6140-6149, Dec. 2001
• Comparison of Fas- versus perforin-mediated pathways of cytotoxicity in TCR- and Thy-1-activated murine T cells, Kojima H, Toda M, Sitkovsky MV, Int Immunol, 12(3), 365-374, Mar. 2000
• Herpes simplex virus as an in situ cancer vaccine for the induction of specific anti-tumor immunity, Toda M, Rabkin SD, Kojima H, Martuza RL, Hum Gene Ther, 10(3), 385-393, Feb. 1999

  DOI
• In situ cancer vaccination: an IL-12 defective vector/replication-competent herpes simplex virus combination induces local and systemic antitumor activity, Toda M, Martuza RL, Kojima H, Rabkin SD, J Immunol, 160(9), 4457-4464, May 1998
• Memory of extracellular adenosine A2A purinergic receptor-mediated signaling in murine T cells, Koshiba M, Kojima H, Huang S, Apasov S, Sitkovsky MV, J Biol Chem, 272(41), 25881-25889, Oct. 1997
• Leukocyte function-associated antigen-1-dependent lysis of Fas+ (CD95+/Apo-1+) innocent bystanders by antigen-specific CD8+ CTL, Kojima H, Eshima K, Takayama H, Sitkovsky MV, J Immunol, 159(6), 2728-2734, Sep. 1997
• Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes, Kojima H, Shinohara N, Hanaoka S, Someya-Shirota Y, Takagaki Y, Ohno H, Saito T, Katayama T, Yagita H, Okumura K, Shinkai Y, Alt FW, Matsuzawa A, Yonehara S, Takayama H, Immunity, 1(5), 357-364, Aug. 1994
• Antigen-specific directional target cell lysis by perforin-negative T lymphocyte clones, Takayama H, Shinohara N, Kawasaki A, Someya Y, Hanaoka S, Kojima H, Yagita H, Okumura K, Shinkai Y, Int Immunol, 3(11), 1149-1156, Nov. 1991

Other
• 67, 115-120, 2017
• 62, 355-358, 2014
• 59, 425-429, Apr. 2013
• 57, 367-370, Apr. 2012
• 56, 97-102, Jul. 2011
• 46, 560-565, Dec. 2006
• Hypoxia-inducible factor 1alpha-deficient chimeric mice as a model to study abnormal B lymphocyte development and autoimmunity, Kojima H, Jones BT, Chen J, Cascalho M, Sitkovsky MV, Methods Enzymol, 381, 218-229, 2004

  DOI
• Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors, Sitkovsky MV, Lukashev D, Apasov S, Kojima H, Koshiba M, Caldwell C, Ohta A, Thiel M, Annu Rev Immunol, 22, 657-682, 2004

  DOI
• HIF-1 alpha deficiency perturbs T and B cell functions, Kojima H, Sitkovsky MV, Cascalho M, Curr Pharm Des, 9(23), 1827-1832, 2003
• 5, 273-278, Aug. 1995
• Cytotoxic T lymphocytes: the newly identified Fas (CD95)-mediated killing mechanism and a novel aspect of their biological functions, Takayama H, Kojima H, Shinohara N, Adv Immunol, 60, 289-321, 1995

Unclear
• IL-21 and IL-5 coordinately induce surface IgA+ cells., Hashiguchi Masaaki, Kashiwakura Yuji, Kanno Yumiko, Kojima Hidefumi, Kobata Tetsuj, Immunology letters, 224, 2020

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• Peyer's patches contain abundant isotype-switched B cells with activated phenotypes and are inductive sites for T-independent anti-DNA IgA., Hashiguchi Masaaki;Kashiwakura Yuji;Kojima Hidefumi;Kanno Yumiko;Kobata Tetsuji, Immunology letters, 211, 53-59, 2019

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• Tumor necrosis factor superfamily member (TNFSF) 13 (APRIL) and TNFSF13B (BAFF) downregulate homeostatic immunoglobulin production in the intestines., Hashiguchi Masaaki;Kashiwakura Yuji;Kanno Yumiko;Kojima Hidefumi;Kobata Tetsuji, Cellular immunology, 323, 41-48, 2018

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• Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination., Abbott Robert K, Thayer Molly, Labuda Jasmine, Silva Murillo, Philbrook Phaethon, Cain Derek W, Kojima Hidefumi, Hatfield Stephen, Sethumadhavan Shalini, Ohta Akio, Reinherz Ellis L, Kelsoe Garnett, Sitkovsky Michai, Journal of immunology (Baltimore, Md. : 1950), 197(10), 2016

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Books etc

• Cytotoxic Cells: Basic mechanisms and Medical Applications, Lysis of innocent bystanders by antigen-specific cytotoxic lymphocytes, Joint work, Sitkovsky MV, Henkart PA ed, Lippincott Williams & Wilkins, 2000, 79-86
• Joint work, Aug. 1995, 234-254

Presentations

• TCR-independent CD4+CD25+ regulatory T cell activation during immune responses, Kojima H, Kashiwakura Y, Hashiguchi M, Kobata T, Aug. 2013, Public symposium, 15th international Congress of Immunology, True
• NFκB attenuates IL-5 production and upregulates T-box transcription factors in Th2-like T cells, Hashiguchi M, Kobayashi A, Kashiwakura Y, Kojima H, Kanno Y, Kobata T, Aug. 2013, Poster presentation, 15th international Congress of Immunology, True
• CD2-mediated regulation of peripheral CD4+CD25+ regulatory T cell apoptosis accompanied by downregulation of Bim, Kashiwakura Y, Sakurai D, Kanno Y, Hashiguchi M, Kobayashi A, Kurosu A, Tokudome S, Kobata T, Kojima H, Aug. 2013, Poster presentation, 15th international Congress of Immunology, True
• IL-7 regulated Hypoxia inducible factor-1α controls the glycolytic pathway during B cell development in a stage specific manner, Kojima H, Kanno Y, Kobayashi A, Sakurai D, Hase H, Sitkovsky MV, Kobata T, Aug. 2010, Poster presentation, 14th international Congress of Immunology, True
• Crucial role of CD2 in the survival and function of CD4+CD25+ regulatory T cells supported by the stromal cells from secondary lymphoid organs, Sakurai D, Kanno Y, Hase H, Kobata T, Kojima H, Aug. 2010, Poster presentation, 14th international Congress of Immunology, True
• IL-35 enhances the regulatory function of CD4+CD25+ T cells isolated from human peripheral blood, Nakano S, Sakurai D, Kanno Y, Kojima H, Takasaki Y, Kobata T, Hase H, Aug. 2010, Poster presentation, 14th international Congress of Immunology, True
• Stage-specific glycolysis regulated by HIF-1α in B cell development, Kojima H, Sakurai D, Sitkovsky MV, Kobata T, Mar. 2006, Poster presentation, Keystone Symposia “Tolerance, Autoimmunity and Immune regulation”, True
• BAFF/BLyS Can Potentiate B-Cell Selection with the B-Cell Co-Receptor Complex, Sakurai D, Hase H, Kanno Y, Kojima H, Kojima M, Kobata T, Jul. 2004, Poster presentation, 12th International Congress of Immunology, True
• Antigen-Specific CTL Development Regulated by CD25+CD4+ Regulatory T Cells, Kojima H, Kobata T, Jul. 2004, Poster presentation, 12th International Congress of Immunology, True
• CD70/CD27 interaction protects human B cells from anti-IgM-induced apoptosis and activating caspase3, Hase H, Kannno Y, Kojima H, Okumura K, Kobata T, Jul. 2001, Public symposium, 11th International Congress of Immunology, True
• Autoimmunity and the distortion of B cell development in hypoxia-inducible factor1α deficient chimeric mice, Kojima H, Gu H, Nomura S, Kobata T, Carmeliet P, Semenza GL, Sitkovsky MV, Jul. 2001, Public symposium, 11th International Congress of Immunology, True
• Mechanisms of bystander target cell lysis by antigen specific cytotoxic T lymphocytes, Kojima H, Eshima K, Takayama H, Sitkovsky MV, Apr. 1997, Public symposium, at EMBO Workshop on Cell-Mediated Cytotoxicity, True
• PP2A protein phosphatase in regulation of cognate interactions involved in the FasR/FasL and granule exocytosis mediated cytotoxicity, Kojima H, Takayama H, Shinohara N, Sitkovsky MV, Jun. 1996, Poster presentation, ASBM/ASIP/AAI Joint Meeting, True
• Mechanism of Fas (CD95)-dependent cytotoxicity mediated by cytotoxic T lymphocytes, Takayama H, Kojima H, Kataoka T, Shinohara N, Jul. 1995, Public symposium, 9th International Congress of Immunology, True
• Specific suppression of antibody responses by CD4+ CTL and its defect in gld/gld mice, Shinohara N, Kojima H, Komano H, Takayama H, Jul. 1995, Poster presentation, 9th International Congress of Immunology, True
• Cytotoxic activities of perforin-deficient mutant T lymphocytes, Kojima H, Shinohara N, Hanaoka-Tahara S, Someya-Shirota Y, Ohno H, Saito T, Kawasaki A, Yagita H, Okumura K, Shinkai Y, Alt FW, Takayama H, Apr. 1994, Public symposium, Experimental Biology ’94, True
• Perforin gene knock-out by homologous recombination of CTL clones and generation of perforin-deficient mice, Kojima H, Ohno H, Hanaoka S, Takayama H, Katayama T, Saito T, Shinohara N, Aug. 1993, Public symposium, EMBO Workshop on Cell-Mediated Cytotoxicity, True
• Role of perforin in CTL mediated cytolysis, Kojima H, Takayama H, Hanaka S, Takagaki Y, Shinohara N, Feb. 1992, Poster presentation, Winter Advanced Course for Immunology and Infectious disease ’92, True

学内助成金

• 2010, 2010
• 2001, 2001

Educational activity

FD活動

• 2012
• 2009
• 2008
• 2008
• 2005