HAYASHI KEITAROU

Profiles

Profiles

• 氏名

  HAYASHI KEITAROU

Affiliation

• Department of Pharmacology and Toxicology, Associate Professor

Research achievements

Awards

• 2011, Author, Japan society

Published Papers

Original paper
• Effects of 1,5-anhydro-D-glucitol on insulin secretion both in in vitro and ex vivo pancreatic preparations., Ouchi Motoshi;Morita Asuka;Satoh Keitaro;Kobayashi Shunsuke;Terada Misao;Kon Hiroe;Hayashi Keitaro;Suzuki Tatsuya;Oba Kenzo;Sugihara Hitoshi;Yasutake Masahiro;Anzai Naohiko;Fujita Tomoe, Journal of pharmacological sciences, 149(2), 66-72, Jun. 2022

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• LAT1-specific inhibitor ameliorates severe autoimmune arthritis in SKG mouse., Owada Takayoshi;Kurasawa Kazuhiro;Endou Hitoshi;Fujita Tomoe;Anzai Naohiko;Hayashi Keitaro, International immunopharmacology, 109, 108817, 11 May 2022

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• Antitumor effect of dimethyl itaconate on thymic carcinoma by targeting LDHA-mTOR axis., Hayashi Keitaro;Nakazato Yoshimasa;Ouchi Motoshi;Fujita Tomoe;Endou Hitoshi;Chida Masayuki, Life sciences, 282, 119847, 01 Oct. 2021

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• Clinical Significance of 18F-fluorodeoxyglucose and Glucose Transporter 1 mRNA in Clear Cell Renal Cell Carcinoma., Betsunoh Hironori;Sakamoto Setsu;Kaji Yasushi;Nukui Akinori;Kobayashi Minoru;Yashi Masahiro;Hayashi Keitaro;Anzai Naohiko;Kamai Takao, Anticancer research, 41(10), 5179-5188, Oct. 2021

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• L-type amino acid transporter 1 inhibitor suppresses murine Th2 cell-mediated bronchial hyperresponsiveness independently of eosinophil accumulation., Ito Daiki;Miura Kento;Saeki Mayumi;Yamasaki Norimasa;Ogata Sawako;Koyama Teidai;Hiroi Takachika;Mori Akio;Endou Hitoshi;Hayashi Keitaro;Kaminuma Osamu, Asia Pacific allergy, 11(3), e33, Jul. 2021

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• Na+/K+-ATPase α4 regulates sperm hyperactivation while Na+/K+-ATPase α1 regulates basal motility in hamster spermatozoa., Takei Gen L;Hayashi Keitaro, Theriogenology, 157, 48-60, Nov. 2020

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• L-type amino acid transporter 1 (LAT1)-specific inhibitor is effective against T cell-mediated nasal hyperresponsiveness., Kaminuma Osamu;Nishimura Tomoe;Saeki Mayumi;Yamasaki Norimasa;Ogata Sawako;Fujita Tomoe;Endou Hitoshi;Hayashi Keitaro, Allergology international : official journal of the Japanese Society of Allergology, 69(3), 455-458, Jul. 2020

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• Imaging of lysophosphatidylcholine in an induced pluripotent stem cell-derived endothelial cell network., Shimizu Yasuo;Nakamura Yusuke;Horibata Yasuhiro;Fujimaki Mio;Hayashi Keitaro;Uchida Nobuhiko;Morita Hiroko;Arai Ryo;Chibana Kazuyuki;Takemasa Akihiro;Sugimoto Hiroyuki, Regenerative therapy, 14, 299-305, Jun. 2020

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• Development of an organ bath technique for isolated rat pancreas preparations to assess the effect of 1,5-AG on insulin secretion., Morita Asuka;Ouchi Motoshi;Satoh Keitaro;Terada Misao;Kon Hiroe;Wakashin Hidefumi;Hayashi Keitaro;Anzai Naohiko;Oba Kenzo;Shimizu Akira;Fujita Tomoe, Experimental animals, 69(2), 127-134, 24 Apr. 2020

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• Fluvastatin is effective against thymic carcinoma., Hayashi Keitaro;Nakazato Yoshimasa;Morito Noriaki;Sagi Mizuki;Fujita Tomoe;Anzai Naohiko;Chida Masayuki, Life sciences, 240, 117110, 01 Jan. 2020

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• LAT1-specific inhibitor is effective against T cell-mediated allergic skin inflammation., Hayashi Keitaro;Kaminuma Osamu;Nishimura Tomoe;Saeki Mayumi;Matsuoka Kunie;Hiroi Takachika;Jutabha Promsuk;Iwata Yohei;Sugiura Kazumitsu;Owada Takayoshi;Kurasawa Kazuhiro;Okayasu Isao;Ouchi Motoshi;Fujita Tomoe;Kanai Yoshikatsu;Endou Hitoshi;Anzai Naohiko, Allergy, 75(2), 463-467, 2020

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• L-type amino acid transporter 1, LAT1, in growth hormone-producing pituitary tumor cells., Satou Motoyasu;Wang Jason;Nakano-Tateno Tae;Teramachi Mariko;Suzuki Tokiko;Hayashi Keitaro;Lamothe Shawn;Hao Yubin;Kurata Harley;Sugimoto Hiroyuki;Chik Constance;Tateno Toru, Molecular and cellular endocrinology, 515, 110868, 2020

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• Effects of uric acid on vascular endothelial function from bedside to bench., Otani Naoyuki;Toyoda Shigeru;Sakuma Masashi;Hayashi Keitaro;Ouchi Motoshi;Fujita Tomoe;Anzai Naohiko;Tanaka Atsushi;Node Koichi;Uemura Naoto;Inoue Teruo, Hypertension research : official journal of the Japanese Society of Hypertension, 41(11), 923-931, Nov. 2018

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• Reproducible insulin secretion from isolated rat pancreas preparations using an organ bath., Morita Asuka;Ouchi Motoshi;Terada Misao;Kon Hiroe;Kishimoto Satoko;Satoh Keitaro;Otani Naoyuki;Hayashi Keitaro;Fujita Tomoe;Inoue Ken-Ichi;Anzai Naohiko, Experimental animals, 67(1), 15-22, 09 Feb. 2018

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• Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor tofogliflozin., Ouchi Motoshi;Oba Kenzo;Kaku Kohei;Suganami Hideki;Yoshida Akihiro;Fukunaka Yasunori;Jutabha Promsuk;Morita Asuka;Otani Naoyuki;Hayashi Keitaro;Fujita Tomoe;Suzuki Tatsuya;Yasutake Masahiro;Anzai Naohiko, Diabetes, obesity & metabolism, 20(4), 1061-1065, 2018

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• L-Type Amino Acid Transporter 1 Immunoreactivity as a Possible Diagnostic and Prognostic Marker of Thymic Carcinoma., Maeda Sumiko;Nakazato Yoshimasa;Hayashi Keitaro;Nishihira Morimichi;Inoue Takashi;Araki Osamu;Karube Yoko;Kobayashi Satoru;Chida Masayuki, The Tohoku journal of experimental medicine, 246(3), 167-174, 2018

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• 92(2), 200-206, Mar. 2017

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• Inhibition of l-type amino acid transporter 1 activity as a new therapeutic target for cholangiocarcinoma treatment., Yothaisong Supak;Dokduang Hasaya;Anzai Naohiko;Hayashi Keitaro;Namwat Nisana;Yongvanit Puangrat;Sangkhamanon Sakkarn;Jutabha Promsuk;Endou Hitoshi;Loilome Watcharin, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 39(3), 1010428317694545, Mar. 2017

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• 409(4), 1007-1016, Feb. 2017

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• Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment., Hayashi Keitaro;Anzai Naohiko, World journal of gastrointestinal oncology, 9(1), 21-29, 15 Jan. 2017

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• LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells., Hayashi Keitaro;Jutabha Promsuk;Maeda Sumiko;Supak Yothaisong;Ouchi Motoshi;Endou Hitoshi;Fujita Tomoe;Chida Masayuki;Anzai Naohiko, Journal of pharmacological sciences, 132(3), 201-204, Nov. 2016

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• 43(1), 23-29, Mar. 2016
• HOXB9 acts as a negative regulator of activated human T cells in response to amino acid deficiency., Hayashi Keitaro;Ouchi Motoshi;Endou Hitoshi;Anzai Naohiko, Immunology and cell biology, 94(6), 612-617, 2016

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• Downregulation of transient receptor potential M6 channels as a cause of hypermagnesiuric hypomagnesemia in obese type 2 diabetic rats., Takayanagi Kaori;Shimizu Taisuke;Tayama Yosuke;Ikari Akira;Anzai Naohiko;Iwashita Takatsugu;Asakura Juko;Hayashi Keitaro;Mitarai Tetsuya;Hasegawa Hajime, American journal of physiology. Renal physiology, 308(12), F1386-F1397, 15 Jun. 2015

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• 14, 412, Jun. 2014

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• LAT1 is a central transporter of essential amino acids in human umbilical vein endothelial cells., Hayashi Keitaro;Jutabha Promsuk;Kamai Takao;Endou Hitoshi;Anzai Naohiko, Journal of pharmacological sciences, 124(4), 511-513, 2014

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• Role of LAT1 in the promotion of amino acid incorporation in activated T cells., Hayashi Keitaro;Anzai Naohiko, Critical reviews in immunology, 34(6), 467-479, 2014

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• LAT1 is a critical transporter of essential amino acids for immune reactions in activated human T cells., Hayashi Keitaro;Jutabha Promsuk;Endou Hitoshi;Sagara Hironori;Anzai Naohiko, Journal of immunology (Baltimore, Md. : 1950), 191(8), 4080-4085, 15 Oct. 2013

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• c-Myc is crucial for the expression of LAT1 in MIA Paca-2 human pancreatic cancer cells., Hayashi Keitaro;Jutabha Promsuk;Endou Hitoshi;Anzai Naohiko, Oncology reports, 28(3), 862-866, Sep. 2012

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• HSP90 is crucial for regulation of LAT expression in activated T cells., Hayashi Keitaro;Kamikawa Yuichiro, Molecular immunology, 48(6-7), 941-946, Mar. 2011

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• A novel human organic anion transporter NPT4 mediates the transport of ochratoxin A., Jutabha Promsuk;Anzai Naohiko;Hayashi Keitaro;Domae Mariko;Uchida Kohsuke;Endou Hitoshi;Sakurai Hiroyuki, Journal of pharmacological sciences, 116(4), 392-396, 2011

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• Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Ctheta., Melowic Heather R;Stahelin Robert V;Blatner Nichole R;Tian Wen;Hayashi Keitaro;Altman Amnon;Cho Wonhwa, The Journal of biological chemistry, 282(29), 21467-21476, 20 Jul. 2007

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• Protein kinase C theta (PKCtheta): a key player in T cell life and death., Hayashi Keitaro;Altman Amnon, Pharmacological research, 55(6), 537-544, Jun. 2007

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• Filamin A is required for T cell activation mediated by protein kinase C-theta., Hayashi Keitaro;Altman Amnon, Journal of immunology (Baltimore, Md. : 1950), 177(3), 1721-1728, 01 Aug. 2006

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• Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect., Hundt Matthias;Tabata Hiroki;Jeon Myung-Shin;Hayashi Keitaro;Tanaka Yoshihiko;Krishna Roma;De Giorgio Lauren;Liu Yun-Cai;Fukata Masaki;Altman Amnon, Immunity, 24(5), 513-522, May 2006

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• Reduction of Runx1 transcription factor activity up-regulates Fas and Bim expression and enhances the apoptotic sensitivity of double positive thymocytes., Abe Natsumi;Kohu Kazuyoshi;Ohmori Hidetaka;Hayashi Keitaro;Watanabe Toshio;Hozumi Katsuto;Sato Takehito;Habu Sonoko;Satake Masanobu, Journal of immunology (Baltimore, Md. : 1950), 175(7), 4475-4482, 01 Oct. 2005

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• Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage., Kohu Kazuyoshi;Sato Takehito;Ohno Shin-Ichiro;Hayashi Keitaro;Uchino Ryuji;Abe Natsumi;Nakazato Megumi;Yoshida Naomi;Kikuchi Toshiaki;Iwakura Yoichiro;Inoue Yoshihiro;Watanabe Toshio;Habu Sonoko;Satake Masanobu, Journal of immunology (Baltimore, Md. : 1950), 174(5), 2627-2636, 01 Mar. 2005

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• Requirement of transcription factor AML1 in proliferation of developing thymocytes., Sato Takehito;Ito Ryoji;Nunomura Satoshi;Ohno Shin-ichiro;Hayashi Keitaro;Satake Masanobu;Habu Sonoko, Immunology letters, 89(1), 39-46, 09 Oct. 2003

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• The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression., Komine Okiru;Hayashi Keitaro;Natsume Waka;Watanabe Toshio;Seki Youichi;Seki Noriyasu;Yagi Ryoji;Sukzuki Wataru;Tamauchi Hidekazu;Hozumi Katsuto;Habu Sonoko;Kubo Masato;Satake Masanobu, The Journal of experimental medicine, 198(1), 51-61, 07 Jul. 2003

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• Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells, K Hayashi, W Natsume, T Watanabe, N Abe, N Iwai, H Okada, Y Ito, M Asano, Y Iwakura, S Habu, Y Takahama, M Satake, J Immunol, 167, 4957, 2001
• Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage, K Hayashi , N Abe, T Watanabe, M Obinata, M Ito, T Sato, S Habu, M Satake, J Immunol, 167, 4957, 01 Nov. 2001
• Overexpression of AML1 renders a T hybridoma resistant to T cell receptor-mediated apoptosis, M Fujii, K Hayashi, M Niki, N Chiba, K Meguro, K Endo, J Kameoka, S Ito, K Abe, T Watanabe, M Satake, Oncogene, 17, 1813, 08 Oct. 1998
• The chimeric protein, PEBP2 beta/CBF beta-SMMHC, disorganizes cytoplasmic stress fibers and inhibits transcriptional activation, Y Tanaka 1 , M Fujii, K Hayashi, N Chiba, T Akaishi, R Shineha, T Nishihira, S Satomi, Y Ito, T Watanabe, M Satake, Oncogene, 13 Aug. 1998
• Hamster Sperm Possess Functional Na+/Ca2+-Exchanger 1: Its Implication in Hyperactivation., Takei Gen L;Ogura Yuhei;Ujihara Yoshihiro;Toyama Fubito;Hayashi Keitaro;Fujita Tomoe, International journal of molecular sciences, 24(10), 17 May 2023

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• JPH203, a LAT1 inhibitor, alleviates steroid-resistant murine airway inflammation mediated by Th17 cells., Hayashi Keitaro;Saeki Mayumi;Miura Kento;Yamasaki Norimasa;Matsuda Masaya;Shimora Hayato;Nabe Takeshi;Shimizu Yasuo;Fujita Tomoe;Endou Hitoshi;Kaminuma Osamu, Allergy, 29 Jun. 2023

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Review paper
• L-type amino acid transporter 1 as a target for inflammatory disease and cancer immunotherapy., Hayashi Keitaro;Anzai Naohiko, Journal of pharmacological sciences, 148(1), 31-40, Jan. 2022

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• Therapeutic Potential for Intractable Asthma by Targeting L-Type Amino Acid Transporter 1., Hayashi Keitaro;Kaminuma Osamu, Biomolecules, 12(4), 2022

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• 73(5), 486-492, May 2020
• 157(5), 305-309, Sep. 2022

Other
• 44(2), 194, Jul. 2017
• 6(増刊), 205, Mar. 2017
• 78(3), 58, May 2016
• 43(1), 73-78, Mar. 2016

Unclear
• The Effects of Trypsin Inhibitor on Insulin Secretion Using Rat Pancreas in an Organ Bath., Morita Asuka;Ouchi Motoshi;Satoh Keitaro;Kobayashi Shunsuke;Terada Misao;Wakashin Hidefumi;Kon Hiroe;Hayashi Keitaro;Anzai Naohiko;Shimizu Akira;Sugihara Hitoshi;Oba Kenzo;Fujita Tomoe, In vivo (Athens, Greece), 35(5), 2551-2558

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Public grant (competitive fund)

• Development of new therapeutic strategies for thymic carcinoma targeting LAT1, 科学研究費助成事業(獨協医科大学, 獨協医科大学), Masayuki Chida, 01 Apr. 2017 - 31 Mar. 2020
• Suppressive effects of LAT1-specific inhibitor on osteoclastgenesis, 科学研究費助成事業(獨協医科大学, 獨協医科大学, 獨協医科大学), Keitaro Hayashi, 01 Apr. 2017 - 31 Mar. 2020
• Strategy for epithelial thymic malignancy treatment focusing on L-type amino acid transporter 1, 科学研究費助成事業(獨協医科大学, 獨協医科大学), MASAYUKI CHIDA, Keitaro HAYASHI, 01 Apr. 2014 - 31 Mar. 2016
• Role of LAT1 in T cell activation, 科学研究費助成事業(獨協医科大学, 獨協医科大学, 獨協医科大学), Keitaro HAYASHI, Jutabha PROMSUK, Naohiko ANZAI, Hitoshi ENDOU, 01 Apr. 2012 - 31 Mar. 2015
• Novel regulatory mechanism of renaltubular transporter function by SUMOylation-deSUMOylation, 科学研究費助成事業(獨協医科大学, 獨協医科大学, 獨協医科大学, 獨協医科大学), Naohiko ANZAI, Shu-ichi KOJIMA, Keitarou HAYASHI, Promsuk JUTABHA, 28 Apr. 2011 - 31 Mar. 2013
• New drug development for hyperuricemia targeting novel urate efflux transporter URATv1, 科学研究費助成事業(獨協医科大学, 獨協医科大学, 獨協医科大学, 獨協医科大学, 獨協医科大学, 杏林大学, 杏林大学, 杏林大学, 兵庫医療大学, 大阪大学, 北里大学, 米国Colorado, ジェイファーマ株式会社, 東京薬科大学, 杏林大学, 杏林大学), Naohiko ANZAI, Kohsuke UCHIDA, Shuichi KOJIMA, Mariko DOMAE, Keitaro HAYASHI, Kunimasa YAN, Toru KIMURA, Toshiyuki FUKUTOMI, Daisaku MIURA, Yoshikatsu KANAI, Katsumasa KAWAHARA, Michael F. WEMPE, Hitoshi ENDOU, Ai TSUKADA, Sirirat AMMONPATUMRAT, Thanapol THAMMAPRATIP, -