Researchers Database
FUJISAWA RIYUUICHI
Position： Associate Professor | |||
Last Updated :2025/04/28
Profile and Settings
Research Areas
- Life Science, Virology, retrovirus, pathogenesis, viral receptor, viral replication
- Life Science, Cell biology, Viral receptor, membrane traffic
- Life Science, Medical management and medical sociology, infectioncontrol
- Life Science, Experimental pathology, autoimmune diseases, nephritogenic, endogenous retrovirus
- Life Science, Immunology, chemokines, chemokine receptors, G protein-coupled receptor
- Life Science, Oral pathobiological science
Research Experience
- 01 Apr. 1994, Tohoku University Hospital, Oral Surgery, Japan
- 1994, 1997, The U.S. National Institutes of Health (NIH), The Laboratory of Persistent Viral Diseases (LPVD), U.S. National Institute of Allergy and Infectious Diseases (NIAID), United States
- 1997, 1999, Overseas Research Fellowships (NIH), Japan Society for the Promotion of Science (JSPS), United States
- 1999, 2001, Kinki University School of Medicine, Department of Microbiology, Assistant Professor, Japan
- 01 Jan. 2002, 30 Sep. 2004, Dokkyo Medical University School of Medicine, Department of Microbiology, Assistant Professor, Japan
- 01 Oct. 2004, 31 Mar. 2007, Dokkyo Medical University School of Medicine, Department of Microbiology, Lecturer, Japan
- 01 Apr. 2007, 31 Jul. 2013, Dokkyo Medical University School of Medicine, Department of Microbiology, Associate Professor, Japan
- 01 Aug. 2013, Dokkyo Medical University School of Nursing, Department of Medical Science of Nursing (Medical Microbiology), Associate Professor, Japan
Education
Research achievements
Awards
Published Papers
- Host cell-specific effects of lentiviral accessory proteins on the eukaryotic cell cycle progression, Matsuda M, Arai A, Nakamura Y, Fujisawa R, Masuda M, Microbes Infect, 11(6-7), 646-653, May 2009
- Ecotropic murine leukemia virus envelope protein affects interaction of cationic amino acid transporter 1 with clathrin adaptor protein complexes, leading to receptor downregulation, Fujisawa R, Masuda M, Virology, 368(2), 342-350, Nov. 2007
- Cell cycle arrest induction by an adenoviral vector expressing HIV-1 Vpr in bovine and feline cells, Matsuda M, Matsuda N, Watanabe A, Fujisawa R, Yamamoto K, Masuda M, Biochem Biophys Res Commun, 311(3), 748-753, Nov. 2003
- IFN-gamma-inducible expression of thymus and activation-regulated chemokine/CCL17 and macrophage-derived chemokine/CCL22 in epidermal keratinocytes and their roles in atopic dermatitis, Horikawa T, Nakayama T, Hikita I, Yamada H, Fujisawa R, Bito T, Harada S, Fukunaga A, Chantry D, Gray PW, Morita A, Suzuki R, Tezuka T, Ichihashi M, Yoshie O, Int Immunol, 14(7), 767-773, Jul. 2002
- Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis, Fujisawa T, Fujisawa R, Kato Y, Nakayama T, Morita A, Katsumata H, Nishimori H, Iguchi K, Kamiya H, Gray PW, Chantry D, Suzuki R, Yoshie O, J Allergy Clin Immunol, 110(1), 139-146, Jul. 2002
- Human B cells immortalized with Epstein-Barr virus upregulate CCR6 and CCR10 and downregulate CXCR4 and CXCR5, Nakayama T, Fujisawa R, Izawa D, Hieshima K, Takada K, Yoshie O, J Virol, 76(6), 3072-3077, Mar. 2002
- Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells, Yoshie O, Fujisawa R, Nakayama T, Harasawa H, Tago H, Izawa D, Hieshima K, Tatsumi Y, Matsushima K, Hasegawa H, Kanamaru A, Kamihira S, Yamada Y, Blood, 99(5), 1505-1511, Mar. 2002
- N-terminal cleavage fragment of glycosylated Gag is incorporated into murine oncornavirus particles, Fujisawa R, McAtee FJ, Favara C, Hayes SF, Portis JL, J Virol, 75(22), 11239-11243, Nov. 2001
- Proinflammatory cytokines induce liver and activation-regulated chemokine/macrophage inflammatory protein-3alpha/CCL20 in mucosal epithelial cells through NF-kappaB [correction of NK-kappaB], Fujiie S, Hieshima K, Izawa D, Nakayama T, Fujisawa R, Ohyanagi H, Yoshie O, Int Immunol, 13(10), 1255-1263, Oct. 2001
- Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes, Nomiyama H, Hieshima K, Nakayama T, Sakaguchi T, Fujisawa R, Tanase S, Nishiura H, Matsuno K, Takamori H, Tabira Y, Yamamoto T, Miura R, Yoshie O, Int Immunol, 13(8), 1021-1029, Aug. 2001
- Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3 alpha/CCL20 by epidermal keratinocytes and its role in atopic dermatitis, Nakayama T, Fujisawa R, Yamada H, Horikawa T, Kawasaki H, Hieshima K, Izawa D, Fujiie S, Tezuka T, Yoshie O, Int Immunol, 13(1), 95-103, Jan. 2001
- Roles of endogenous retroviruses and platelets in the development of vascular injury in spontaneous mouse models of autoimmune diseases, Miyazawa M, Tabata N, Fujisawa R, Hashimoto K, Shiwaku H, Takei YA, Int J Cardiol, 75 Suppl 1, S65-S73; discussion S75-6, Aug. 2000
- Establishment of monoclonal anti-retroviral gp70 autoantibodies from MRL/lpr lupus mice and induction of glomerular gp70 deposition and pathology by transfer into non-autoimmune mice, Tabata N, Miyazawa M, Fujisawa R, Takei YA, Abe H, Hashimoto K, J Virol, 74(9), 4116-4126, May 2000
- Increased chemokine receptor CCR7/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells, Hasegawa H, Nomura T, Kohno M, Tateishi N, Suzuki Y, Maeda N, Fujisawa R, Yoshie OFujita S, Blood, 95(1), 30-8, Jan. 2000
- Induction of microthrombotic thrombocytopenia in normal mice by transferring a platelet-reactive, monoclonal anti-gp70 autoantibody established from MRL/lpr mice: an autoimmune model of thrombotic thrombocytopenic purpura, Hashimoto K, Tabata N, Fujisawa R, Matsumura H, Miyazawa M, Clin Exp Immunol, 119(1), 47-56, Jan. 2000
- Anti-cytoplasmic autoantibodies reactive with epithelial cells of the salivary gland in sera from patients with Sjogren's syndrome: their disease- and organ-specificities, Sakamoto M, Miyazawa M, Mori S, Fujisawa R, J Oral Pathol Med, 28(1), 20-5, Jan. 1999
- The neuroinvasiveness of a murine retrovirus is influenced by a dileucine-containing sequence in the cytoplasmic tail of glycosylated Gag, Fujisawa R, McAtee FJ, Wehrly K, Portis JL, J Virol, 72(7), 5619-5625, Jul. 1998
- Characterization of glycosylated Gag expressed by a neurovirulent murine leukemia virus: identification of differences in processing in vitro and in vivo, Fujisawa R, McAtee FJ, Zirbel JH, Portis JL, J Virol, 71(7), 5355-5360, Jul. 1997
- Restriction of Friend virus-induced erythroid cell proliferation by CD4+ T-lymphocytes that recognize a single gp70 epitope, Miyazawa M, Fujisawa R, Leukemia, 11 Suppl 3, 227-229, Apr. 1997
- The glycosylated gag protein of MuLV is a determinant of neuroinvasiveness: analysis of second site revertants of a mutant MuLV lacking expression of this protein, Portis JL, Fujisawa R, Mcatee FJ, Virology, 226(2), 384-392, Dec. 1996
- A single retroviral gag precursor signal peptide recognized by FBL-3 tumor-specific cytotoxic T lymphocytes, Kondo T, Uenishi H, Shimizu T, Hirama T, Iwashiro M, Kuribayashi K, Tamamura H, Fujii N, Fujisawa R, Miyazawa M, et al., J Virol, 69(11), 6735-6741, Nov. 1995
- Protective efficacy of nonneutralizing monoclonal antibodies in acute infection with murine leukemia virus, Pincus SH, Cole R, Ireland R, McAtee F, Fujisawa R, Portis J, J Virol, 69(11), 7152-7158, Nov. 1995
- Immunization with a single T helper cell epitope abrogates Friend virus-induced early erythroid proliferation and prevents late leukemia development, Miyazawa M, Fujisawa R, Ishihara C, Takei YA, Shimizu T, Uenishi H, Yamagishi H, Kuribayashi K, J Immunol, 155(2), 748-758, Jul. 1995
- Physiology and pathology of host immune responses to exogenous and endogenous murine retroviruses--from gene fragments to epitopes, Miyazawa M, Fujisawa R, Tohoku J Exp Med, 173(1), 91-103, May 1994
- Infection Control Education Program for Correct Hand Hygiene and Glove Use in Medical School Training, Fujisawa R, Takahashi H, Ohzeki K, Tanaka Y, Okuzumi K, Masuda M, 29(3), 183-188, May 2014
- A Trial toward a Practical Program for Infection Control Education at the Beginning of Postgraduate Clinical Training of Medical Doctors, Masuda M, Fujisawa R, Yamamoto K, Okuzumi K, 20(3), 193-199, Sep. 2005
- 25(14), 558-562, 1993
- Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells, Yoshie O, Fujisawa R, Nakayama T, Harasawa H, Tago H, Izawa D, Hieshima K, Tatsumi Y, Matsushima K, Hasegawa H, Kanamaru A, Kamihira S, Yamada Y, Blood, 99(5), 1505-1511, Mar. 2002
Original paper
MISC
Books etc
- Contributor, 2018, Scholarly book, 4885104165
- Contributor, 2014, Scholarly book, 9784885103124
- Contributor, 2012, Scholarly book, 4758303657
- Contributor, 2012, Scholarly book, 4758303657
- Single translation, 2011, Scholarly book, 4524260617
- Single translation, 2011, Scholarly book, 4524260617
Presentations
- A sequence in the unique 5' open reading frame of the gene encoding glycosylated Gag inhibits processing of Murine Leukemia Virus envelope protein in a polarized epithelial cell., Fujisawa R, Masuda M, The International Workshop on the Current Progress in Enterovirus 71 Research in the Asia-Pacific Region, 2012, Oral presentation, Tokyo, True
- Viral Determinants of MuLV Alter Interaction of Cationic Amino Acid Transporter 1 with Clathrin Adaptor Complexes and Its Intracellular Trafficking., Fujisawa R, Masuda M, The 2004 International Workshop on the Pathogenesis of Animal Retroviruses, 2004, Invited oral presentation, Montreal CANADA, True
- Human 14-3-3 proteins confer susceptibility to the cell cycle arrest induction by HIV-1 vpr upon Schizosaccharomyces pombe., Masuda M, Matsuda N, Watanabe A, Yamazaki S, Tanaka H, Matsuda M, Fujisawa R, Yamamoto K, Cold Spring Harbor "Retroviruses 2004", 2004, 2004, NY USA, True
- MuLV infection affects interaction of cationic amino acid transporter 1 with clathrin adaptor complexes and its intracellular trafficking., Fujisawa R, Masuda M, Cold Spring Harbor "Retroviruses 2004", 2004, NY USA, True
- Polarized Trafficking and Surface Expression of Ecotropic Mulv Receptor Are Regulated by Clathrin-adaptor Complexes., Fujisawa R, Masuda M, The 2003 International Workshop on the Pathogenesis of Animal Retroviruses, 2003, Invited oral presentation, Glasgo UK, True
- Application of GFP-tagged mCAT1 for studying the sorting mechanism of ecotropic MuLV receptor., Masuda M, Masuda M, Yamamoto K, Fujisawa R, The 2002 International Workshop on Retroviral Pathogenesis, 2002, Invited oral presentation, CA USA, True
- Subcellular localization and trafficking of murine ecotropic receptor, mCAT1., Fujisawa R, Yamamoto K, Masuda M, The 2002 International Workshop on Retroviral Pathogenesis, 2002, Invited oral presentation, CA USA, True
- Sequence Motiefs in MuLV Glycosylated Gag Which Influence Virus Dissemination In Vivo., Fujisawa R, McAtee FJ, Portis JL, Cold Spring Harbor "Retroviruses 2001", 2001, NY USA, True, International journal
- Potential Role of Intracellular Sorting Signals in the Function of MuLV Glycosylated Gag., Portis JL, McAtee FJ, Fujisawa R, The 1998 International Workshop on the Pathogenesis of Animal Retroviruses, 1998, Invited oral presentation, CA USA, True, International journal
- Neuroinvasiveness of a Murine Retrovirus Is Influenced by a Dilucine-Containing Sequence in the Cytoplasmic Tail of Glycosylated Gag., Fujisawa R, McAtee FJ, Portis JL, Cold Spring Harbor "Retroviruses 1998", 1998, NY USA, True, International journal
- The Cytoplasmic Domain of Glycosylated Gag Influences Recycling of Cell Surface Protein and Neuroinvasiveness., Fujisawa R, McAtee FJ, Portis JL, NIH Research Festival '97, 1997, MD USA, True, International journal
- Posttranslational Processing of the MuLV Glycosylated Gag Protein and the Possibility of This Protein's Incorporation into the Virus Particles., Fujisawa R, McAtee FJ, Portis JL, Cold Spring Harbor "Retroviruses 1997", 1997, NY USA, True, International journal
- Approaches to Structure/Function Analysis of MuLV Glycosylated Gag., Portis JL, Fujisawa R, McAtee FJ, The 8th International Workshop on the Pathogenesis of Animal Retroviruses, 1996, Saint-Malo France, True, International journal
- Characterization of Cell-Surface Glycosylated Gag Protein Expressed by a Neurovirulent Murine Leukemia Virus., Fujisawa R, McAtee FJ, Portis JL, The 7th International Workshop on the Pathogenesis of Animal Retroviruses, 1995, WA USA, True, International journal
委託研究費
Social contributions
Social Contribution
- Visiting lecture, 18 Jun. 2021
- Meeting, 03 Mar. 2021
- Meeting, 12 Feb. 2021
- Lecture, 04 Dec. 2020
- Lecture, 11 Dec. 2020
- Lecture, 18 Dec. 2020
- Lecture, 12 Nov. 2020
- Lecture, 23 Oct. 2020
- Lecture, 16 Oct. 2020
- Lecture, 04 Dec. 2017
- 05 Jun. 2013
Academic Contribution
- 2013
- Microbiology and Immunology, 2013, International academic contribution
- Summer Retrovirus Conference 2006 (SRC 2006), Competition etc, 27 Jul. 2006, 29 Jul. 2006