OGAWA TADAYUKI

Profiles

Profiles

• 氏名

  OGAWA TADAYUKI

Affiliation

• Senior Assistant Professor

Profile and Settings

Alternate Names

• T Ogawa

Affiliation

• International Christian University

Degree

• Mar. 2008

Research Interests

• 人体解剖学
• 神経変性疾患
• 精神疾患
• 構造生物学
• 細胞骨格
• 分子モーター
• 質量分析
• タンパク質科学
• 解剖学
• 神経科学
• 細胞生物学

Research Areas

• Life Science, Anatomy
• Life Science, Anatomy and histopathology of nervous system
• Life Science, Cell biology
• Life Science, Biophysics

Committee Memberships

• Nov. 2018, 9999, Society
• May 2016, 9999, Society
• Sep. 2018, May 2019, Society
• Jul. 2015, Jul. 2016, Society

Association Memberships

• アメリカ細胞生物学会
• THE JAPAN NEUROSCIENCE SOCIETY
• THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
• 日本プロテオーム学会
• THE MASS SPECTROMETRY SOCIETY OF JAPAN
• THE BIOPHYSICAL SOCIETY OF JAPAN
• JAPAN SOCIETY FOR CELL BIOLOGY
• THE JAPANESE ASSOCIATION OF ANATOMISTS

Research achievements

Published Papers

Unclear
• Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport, Shogo Yoshihara; Xuguang Jiang; Momo Morikawa; Tadayuki Ogawa; Sotaro Ichinose; Hirooki Yabe; Akiyoshi Kakita; Manabu Toyoshima; Yasuto Kunii; Takeo Yoshikawa; Yosuke Tanaka; Nobutaka Hirokawa, Cell Reports, 35(2), 108971-108971, Apr. 2021

  DOI
• 'Quality' of Schizophrenia-relevant Molecules: from Genetic and Environmental Factors to Proteins, Manabu TOYOSHIMA; Xuguang JIANG; Tadayuki OGAWA; Nobutaka HIROKAWA; Takeo YOSHIKAWA, BUNSEKI KAGAKU, 69(10.11), 531-537, 05 Oct. 2020

  DOI
• Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis., Toyoshima M; Jiang X; Ogawa T; Ohnishi T; Yoshihara S; Balan S; Yoshikawa T; Hirokawa N, Life Science Alliance., 2(5), pii: e201900478., Oct. 2019

  DOI
• The Spatiotemporal Construction of the Axon Initial Segment via KIF3/KAP3/TRIM46 Transport under MARK2 Signaling., Ichinose S; Ogawa T; Jiang X; Hirokawa N, Cell reports, 28(9), 2413-2426, Aug. 2019

  DOI
• Multiple analyses of protein dynamics in solution, Tadayuki Ogawa; Nobutaka Hirokawa, Biophysical Reviews, 10(2), 299-306, 01 Apr. 2018

  DOI
• Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation, Tadayuki Ogawa; Shinya Saijo; Nobutaka Shimizu; Xuguang Jiang; Nobutaka Hirokawa, CELL REPORTS, 20(11), 2626-2638, Sep. 2017

  DOI
• Mechanism of Activity-Dependent Cargo Loading via the Phosphorylation of KIF3A by PKA and CaMKIIa, Sotaro Ichinose; Tadayuki Ogawa; Nobutaka Hirokawa, NEURON, 87(5), 1022-1035, Sep. 2015

  DOI
• Microtubule Destabilizer KIF2A Undergoes Distinct Site-Specific Phosphorylation Cascades that Differentially Affect Neuronal Morphogenesis, Tadayuki Ogawa; Nobutaka Hirokawa, CELL REPORTS, 12(11), 1774-1788, Sep. 2015

  DOI
• Indigenome and Indigenomics : Targeted Quantitative Analysis of Native Biomolecules on Their Expression and Variety of Indigenous Forms ^|^mdash; Represented by Proteins ^|^mdash;, Toshihide NISHIMURA; Makoto KIHARA; Junichi KAMIIE; Hirotaka KAWAKAMI; Yasuhiko BANDO; Andrew J. ALPERT; Tadayuki OGAWA; Hiromasa TOJO, BUNSEKI KAGAKU, 61(6), 445-457, 2012

  DOI
• A common mechanism for microtubule destabilizers - M type kinesins stabilize curling of the protofilament using the class-specific neck and loops, T Ogawa; R Nitta; Y Okada; N Hirokawa, CELL, 116(4), 591-602, Feb. 2004

  DOI
• 2SA01 Atomic model of depolymerization mechanism of micro-tubules by a kinesin superfamily protein, KIF2C, Okada Y., Seibutsu Butsuri, 44(0), S13, 2004

  DOI

MISC

• タンパク質複合体の溶液中解析を活かす測定試料前処理系の改良, 小川覚之; 西條慎也; 清水伸隆; JIANG Xuguang; 廣川信隆, Photon Factory News, 35(4), 9‐12, Feb. 2018
• 神経形成を支える分子機構―微小管脱重合機構と神経突起伸長制御―, 小川覚之; 西條慎也; 清水伸隆; 蒋緒光; 蒋緒光; 廣川信隆; 廣川信隆, 日本解剖学会総会・全国学術集会講演プログラム・抄録集, 123rd, 94, 2018
• The Smart Mechanism of Microtubule Depolymerizing Nano-Machine, Ogawa T; Saijo S; Shimizu N; Jiang X; Hirokawa N, Photon Factory Highlights 2017, 4, 48-49, 2018
• SEC-SAXS Analysis Revealed the Transitional Complex of Microtubule Depolymerizing Kinesin and Tubulin in Solution., Tadayuki OGAWA; Shinya SAIJO; Nobutaka SHIMIZU; Nobutaka HIROKAWA, Photon Factory Activity Report 2017, Vol.35, No.66, 2018
• The Crystal Structure of Microtubule Depolymerizing Kinesin KIF2 in Transitional States., Tadayuki OGAWA; Xuguang JIANG; Nobutaka HIROKAWA, Photon Factory Activity Report 2017, Vol.35, No.55, 2018
• 異なる特異的リン酸化カスケードによる微小管脱重合蛋白質KIF2Aの制御機構, 小川覚之; 小川覚之; 廣川信隆; 廣川信隆, 日本細胞生物学会大会(Web), 68th, ROMBUNNO.T1‐6 (WEB ONLY), 2016
• 異なる特異的リン酸化カスケードによる微小管脱重合蛋白質KIF2Aの制御機構, 小川覚之; 小川覚之; 廣川信隆; 廣川信隆, 日本解剖学会総会・全国学術集会講演プログラム・抄録集, 121st, 132, 2016
• 異なる特異的リン酸化カスケードによる微小管脱重合蛋白質の制御機構, 小川覚之; 小川覚之; 廣川信隆; 廣川信隆, 日本プロテオーム学会大会プログラム・抄録集, 2016, 86, 2016
• 神経細胞における微小管脱重合の制御機構の解明:Phos‐tagからリン酸化定量プロテオミクスまで, 小川覚之; 小川覚之; 廣川信隆; 廣川信隆, 電気泳動(Web), 60(Suppl), s16(J‐STAGE), 2016
• 異なる特異的リン酸化カスケードによる微小管脱重合蛋白質KIF2Aの制御機構, 小川覚之; 廣川信隆, 日本生化学会大会(Web), 88th, 3T23-15(3P0075) (WEB ONLY), 2015
• Microtubule Destabilizer KIF2A Undergoes Distinct Site-specific Phosphorylation Cascades for Neuronal Morphogenesis, T. Ogawa; N. Hirokawa, MOLECULAR BIOLOGY OF THE CELL, 26, 2015
• Mechanism of Activity-dependent Cargo Loading via the Phosphorylation of KIF3A by PKA and CaMKIIa, S. Ichinose; T. Ogawa; N. Hirokawa, MOLECULAR BIOLOGY OF THE CELL, 26, 2015
• A common mechanism for microtubule destabilizers-M-Type kinesins stabilize curling of the protofilament using the class-specific neck and loops., T Ogawa; R Nitta; Y Okada; N Hirokawa, MOLECULAR BIOLOGY OF THE CELL, 15, 36A-36A, Nov. 2004
• A common mechanism for microtubule destabilizers-M-type kinesins stabilize curling of the protofilament using the class-specific neck and loops, Tadayuki Ogawa; Ryo Nitta; Yasushi Okada; Nobutaka Hirokawa, CELL STRUCTURE AND FUNCTION, 29, 37-37, May 2004

Presentations

• 疾患脳から迫る疾患特異的金属蛋白質の分子構造病態解析, 小川覚之, 第21回 日本蛋白質科学会年会 (オンライン開催), 17 Jun. 2021, Public symposium
• 量子ビームで迫る微小管関連タンパク質構造動態：疾患から分子構造病態まで, 小川覚之, 2020年度量子ビームサイエンスフェスタ (オンライン開催), 11 Mar. 2021, Invited oral presentation
• タンパク質の質的変化を如何に捉えるか？, 小川覚之, 第42回日本分子生物学会年会 （福岡）, 05 Dec. 2019, Public symposium
• 微小管脱重合反応を推進する遷移段階KIF2-チューブリン複合体の溶液解析, 小川覚之; 西條慎也; 清水伸隆; 蒋緒光; 廣川信隆, 分子生物学会, 29 Nov. 2018, Public symposium, False
• The Smart Nano-Machine that demolishes the Microtubule Cytoskeleton in Cells, Ogawa Tadayuki, International BMS Symposium, 26 Oct. 2018, Invited oral presentation, True
• Mechanism of Protein Dynamics Revealed by the Combination of Multiple Protein Analyses in Solution, Tadayuki Ogawa; Nobutaka Hirokawa, 生物物理学会, 16 Sep. 2018, Public symposium, False
• Mechanism of Catalytic Microtubule Depolymerization via KIF2-tubulin Transitional Conformation, Ogawa Tadayuki, American Society for Cell Biology, 05 Dec. 2017, Poster presentation, True
• 神経細胞における微小管脱重合の制御機構の解明：Phos-tagからリン酸化定量プロテオミクスまで, 小川 覚之, 日本電気泳動学会, 26 Aug. 2016, Invited oral presentation, False
• Microtubule Destabilizer KIF2A Undergoes Distinct Site-specific Phosphorylation Cascades that Differentially Affect Neuronal Morphogenesis, Ogawa Tadayuki, International Congress of Cell Biology, 21 Jul. 2016, Oral presentation, True
• Microtubule Destabilizer KIF2A Undergoes Distinct Site-specific Phosphorylation Cascades for Neuronal Morphogenesis, Ogawa Tadayuki, American Society for Cell Biology, 15 Dec. 2015, Poster presentation, True
• 蛋白質複合体の遷移状態を解析する, 小川 覚之, 生体分子相互作用解析フォーラム(BMIA)ワークショップ, 27 Aug. 2015, Invited oral presentation, False
• 生命科学研究における質量分析, 小川 覚之, JIANミーティング, 22 Aug. 2014, Public discourse, False
• 生命科学研究におけるリン酸化プロテオミクスー基礎と実際ー, 小川 覚之, 微生物化学研究会セミナー, 21 Aug. 2014, Public discourse, False

Educational activity

Teaching Experience

• 99 Dec. 2019, Health Science (class in English), International Christian University
• 20 Apr. 2015, Brain Anatomy, The University of Tokyo, Faculty of Medicine
• 20 Apr. 2006, Histology, The University of Tokyo, Faculty of Medicine
• 20 Apr. 2006, Human Anatomy, The University of Tokyo, Faculty of Medicine