OGAWA TADAYUKI

Profiles

Profiles

• 氏名

  OGAWA TADAYUKI

Affiliation

• Laboratory for Molecular Pathobiology, Associate Professor

Profile and Settings

Alternate Names

• T Ogawa

Affiliation

• International Christian University

Degree

• Mar. 2008

Research Interests

• 人体解剖学
• 神経変性疾患
• 精神疾患
• 構造生物学
• 細胞骨格
• 分子モーター
• 質量分析
• タンパク質科学
• 解剖学
• 神経科学
• 細胞生物学

Research Areas

• Life Science, Anatomy
• Life Science, Anatomy and histopathology of nervous system
• Life Science, Cell biology
• Life Science, Biophysics

Committee Memberships

• Nov. 2018, 9999, Society
• May 2016, 9999, Society
• Sep. 2018, May 2019, Society
• Jul. 2015, Jul. 2016, Society

Association Memberships

• アメリカ細胞生物学会
• THE JAPAN NEUROSCIENCE SOCIETY
• THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
• 日本プロテオーム学会
• THE MASS SPECTROMETRY SOCIETY OF JAPAN
• THE BIOPHYSICAL SOCIETY OF JAPAN
• JAPAN SOCIETY FOR CELL BIOLOGY
• THE JAPANESE ASSOCIATION OF ANATOMISTS

Research achievements

Published Papers

Original paper
• Newly Found Rat CD103 - Dendritic Cells Represent a Highly Immunogenic Subpopulation of Type-2 Conventional Dendritic Cells, Corresponding to Known Dendritic Cell Subsets in Mice and Humans, Yasushi Sawanobori, Tadayuki Ogawa, Hisashi Ueta, Yusuke Kitazawa, Nobuko Tokuda, Immunology, 174(4), 384-401, 04 Jan. 2025

  DOI

Unclear
• Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport, Shogo Yoshihara; Xuguang Jiang; Momo Morikawa; Tadayuki Ogawa; Sotaro Ichinose; Hirooki Yabe; Akiyoshi Kakita; Manabu Toyoshima; Yasuto Kunii; Takeo Yoshikawa; Yosuke Tanaka; Nobutaka Hirokawa, Cell Reports, 35(2), 108971-108971, Apr. 2021

  DOI
• 'Quality' of Schizophrenia-relevant Molecules: from Genetic and Environmental Factors to Proteins, Manabu TOYOSHIMA; Xuguang JIANG; Tadayuki OGAWA; Nobutaka HIROKAWA; Takeo YOSHIKAWA, BUNSEKI KAGAKU, 69(10.11), 531-537, 05 Oct. 2020

  DOI
• Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis., Toyoshima M; Jiang X; Ogawa T; Ohnishi T; Yoshihara S; Balan S; Yoshikawa T; Hirokawa N, Life Science Alliance., 2(5), pii: e201900478., Oct. 2019

  DOI
• The Spatiotemporal Construction of the Axon Initial Segment via KIF3/KAP3/TRIM46 Transport under MARK2 Signaling., Ichinose S; Ogawa T; Jiang X; Hirokawa N, Cell reports, 28(9), 2413-2426, Aug. 2019

  DOI
• Multiple analyses of protein dynamics in solution, Tadayuki Ogawa; Nobutaka Hirokawa, Biophysical Reviews, 10(2), 299-306, 01 Apr. 2018

  DOI
• Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation, Tadayuki Ogawa; Shinya Saijo; Nobutaka Shimizu; Xuguang Jiang; Nobutaka Hirokawa, CELL REPORTS, 20(11), 2626-2638, Sep. 2017

  DOI
• Mechanism of Activity-Dependent Cargo Loading via the Phosphorylation of KIF3A by PKA and CaMKIIa, Sotaro Ichinose; Tadayuki Ogawa; Nobutaka Hirokawa, NEURON, 87(5), 1022-1035, Sep. 2015

  DOI
• Microtubule Destabilizer KIF2A Undergoes Distinct Site-Specific Phosphorylation Cascades that Differentially Affect Neuronal Morphogenesis, Tadayuki Ogawa; Nobutaka Hirokawa, CELL REPORTS, 12(11), 1774-1788, Sep. 2015

  DOI
• Indigenome and Indigenomics : Targeted Quantitative Analysis of Native Biomolecules on Their Expression and Variety of Indigenous Forms ^|^mdash; Represented by Proteins ^|^mdash;, Toshihide NISHIMURA; Makoto KIHARA; Junichi KAMIIE; Hirotaka KAWAKAMI; Yasuhiko BANDO; Andrew J. ALPERT; Tadayuki OGAWA; Hiromasa TOJO, BUNSEKI KAGAKU, 61(6), 445-457, 2012

  DOI
• A common mechanism for microtubule destabilizers - M type kinesins stabilize curling of the protofilament using the class-specific neck and loops, T Ogawa; R Nitta; Y Okada; N Hirokawa, CELL, 116(4), 591-602, Feb. 2004

  DOI
• 2SA01 Atomic model of depolymerization mechanism of micro-tubules by a kinesin superfamily protein, KIF2C, Okada Y., Seibutsu Butsuri, 44(0), S13, 2004

  DOI

MISC

• タンパク質複合体の溶液中解析を活かす測定試料前処理系の改良, 小川覚之; 西條慎也; 清水伸隆; JIANG Xuguang; 廣川信隆, Photon Factory News, 35(4), 9‐12, Feb. 2018
• 神経形成を支える分子機構―微小管脱重合機構と神経突起伸長制御―, 小川覚之; 西條慎也; 清水伸隆; 蒋緒光; 蒋緒光; 廣川信隆; 廣川信隆, 日本解剖学会総会・全国学術集会講演プログラム・抄録集, 123rd, 94, 2018
• The Smart Mechanism of Microtubule Depolymerizing Nano-Machine, Ogawa T; Saijo S; Shimizu N; Jiang X; Hirokawa N, Photon Factory Highlights 2017, 4, 48-49, 2018
• SEC-SAXS Analysis Revealed the Transitional Complex of Microtubule Depolymerizing Kinesin and Tubulin in Solution., Tadayuki OGAWA; Shinya SAIJO; Nobutaka SHIMIZU; Nobutaka HIROKAWA, Photon Factory Activity Report 2017, Vol.35, No.66, 2018
• The Crystal Structure of Microtubule Depolymerizing Kinesin KIF2 in Transitional States., Tadayuki OGAWA; Xuguang JIANG; Nobutaka HIROKAWA, Photon Factory Activity Report 2017, Vol.35, No.55, 2018
• 異なる特異的リン酸化カスケードによる微小管脱重合蛋白質KIF2Aの制御機構, 小川覚之; 小川覚之; 廣川信隆; 廣川信隆, 日本細胞生物学会大会(Web), 68th, ROMBUNNO.T1‐6 (WEB ONLY), 2016
• 異なる特異的リン酸化カスケードによる微小管脱重合蛋白質KIF2Aの制御機構, 小川覚之; 小川覚之; 廣川信隆; 廣川信隆, 日本解剖学会総会・全国学術集会講演プログラム・抄録集, 121st, 132, 2016
• 異なる特異的リン酸化カスケードによる微小管脱重合蛋白質の制御機構, 小川覚之; 小川覚之; 廣川信隆; 廣川信隆, 日本プロテオーム学会大会プログラム・抄録集, 2016, 86, 2016
• 神経細胞における微小管脱重合の制御機構の解明:Phos‐tagからリン酸化定量プロテオミクスまで, 小川覚之; 小川覚之; 廣川信隆; 廣川信隆, 電気泳動(Web), 60(Suppl), s16(J‐STAGE), 2016
• 異なる特異的リン酸化カスケードによる微小管脱重合蛋白質KIF2Aの制御機構, 小川覚之; 廣川信隆, 日本生化学会大会(Web), 88th, 3T23-15(3P0075) (WEB ONLY), 2015
• Microtubule Destabilizer KIF2A Undergoes Distinct Site-specific Phosphorylation Cascades for Neuronal Morphogenesis, T. Ogawa; N. Hirokawa, MOLECULAR BIOLOGY OF THE CELL, 26, 2015
• Mechanism of Activity-dependent Cargo Loading via the Phosphorylation of KIF3A by PKA and CaMKIIa, S. Ichinose; T. Ogawa; N. Hirokawa, MOLECULAR BIOLOGY OF THE CELL, 26, 2015
• A common mechanism for microtubule destabilizers-M-Type kinesins stabilize curling of the protofilament using the class-specific neck and loops., T Ogawa; R Nitta; Y Okada; N Hirokawa, MOLECULAR BIOLOGY OF THE CELL, 15, 36A-36A, Nov. 2004
• A common mechanism for microtubule destabilizers-M-type kinesins stabilize curling of the protofilament using the class-specific neck and loops, Tadayuki Ogawa; Ryo Nitta; Yasushi Okada; Nobutaka Hirokawa, CELL STRUCTURE AND FUNCTION, 29, 37-37, May 2004

Presentations

• 疾患脳から迫る疾患特異的金属蛋白質の分子構造病態解析, 小川覚之, 第21回 日本蛋白質科学会年会 (オンライン開催), 17 Jun. 2021, Public symposium
• 量子ビームで迫る微小管関連タンパク質構造動態：疾患から分子構造病態まで, 小川覚之, 2020年度量子ビームサイエンスフェスタ (オンライン開催), 11 Mar. 2021, Invited oral presentation
• タンパク質の質的変化を如何に捉えるか？, 小川覚之, 第42回日本分子生物学会年会 （福岡）, 05 Dec. 2019, Public symposium
• 微小管脱重合反応を推進する遷移段階KIF2-チューブリン複合体の溶液解析, 小川覚之; 西條慎也; 清水伸隆; 蒋緒光; 廣川信隆, 分子生物学会, 29 Nov. 2018, Public symposium, False
• The Smart Nano-Machine that demolishes the Microtubule Cytoskeleton in Cells, Ogawa Tadayuki, International BMS Symposium, 26 Oct. 2018, Invited oral presentation, True
• Mechanism of Protein Dynamics Revealed by the Combination of Multiple Protein Analyses in Solution, Tadayuki Ogawa; Nobutaka Hirokawa, 生物物理学会, 16 Sep. 2018, Public symposium, False
• Mechanism of Catalytic Microtubule Depolymerization via KIF2-tubulin Transitional Conformation, Ogawa Tadayuki, American Society for Cell Biology, 05 Dec. 2017, Poster presentation, True
• 神経細胞における微小管脱重合の制御機構の解明：Phos-tagからリン酸化定量プロテオミクスまで, 小川 覚之, 日本電気泳動学会, 26 Aug. 2016, Invited oral presentation, False
• Microtubule Destabilizer KIF2A Undergoes Distinct Site-specific Phosphorylation Cascades that Differentially Affect Neuronal Morphogenesis, Ogawa Tadayuki, International Congress of Cell Biology, 21 Jul. 2016, Oral presentation, True
• Microtubule Destabilizer KIF2A Undergoes Distinct Site-specific Phosphorylation Cascades for Neuronal Morphogenesis, Ogawa Tadayuki, American Society for Cell Biology, 15 Dec. 2015, Poster presentation, True
• 蛋白質複合体の遷移状態を解析する, 小川 覚之, 生体分子相互作用解析フォーラム(BMIA)ワークショップ, 27 Aug. 2015, Invited oral presentation, False
• 生命科学研究における質量分析, 小川 覚之, JIANミーティング, 22 Aug. 2014, Public discourse, False
• 生命科学研究におけるリン酸化プロテオミクスー基礎と実際ー, 小川 覚之, 微生物化学研究会セミナー, 21 Aug. 2014, Public discourse, False
• Rat CD103-MHCII+CD45R-CD161+CD172a+ cells are a novel potent subpopulation of cDC2, corresponding to known mouse and human subpopulations., Yasushi Sawanobori, Tadayuki Ogawa, Hisashi Ueta, Yusuke Kitazawa, Nobuko Tokuda, APPW2025, 19 Mar. 2025, 17 Mar. 2025, 19 Mar. 2025, Oral presentation, Chiba, Japan, Japan, Dendritic cells (DCs) are known for their potent capabilities in antigen presentation, T cell priming, and cytokine secretion. They consist of XCR1+ conventional DC1 (cDC1), CD172a+ cDC2, and plasmacytoid DC subsets. While CD11c serves as the primary marker for DCs in mice and humans, rat DCs have traditionally been identified by CD103 molecules. However, this history cannot exclude the possibility of CD103- DC existence in rats. To investigate this possibility, we examined low-density cells from the rat spleen and MHCII-enriched rat thymic cells, finding CD103-MHCII+CD45R-CD161+CD172a+ cells. These cells were negative for CD103 and the B cell marker CD45R, but positive for another rat DC marker CD161 and the cDC2 marker CD172a. For further characterization, we performed microarray analyses on these cells. Principal component analysis, marker gene expression, and similarity to murine counterparts indicated that these cells represent a subpopulation of cDC2. Consequently, we designated this novel subset and the classic rat cDC2 as CD103- cDC2 and CD103+ cDC2, respectively. Subsequently, we investigated the functionality of the rat CD103- and CD103+ cDC2 subsets. Gene set enrichment analyses suggested that the rat CD103- cDC2 subsets are enriched for immune-associated terms, while the rat CD103+ cDC2 subsets are enriched for cell cycle-associated terms. Consistent with this prediction, the rat CD103- cDC2 cells induced enhanced T cell proliferation in mixed lymphocyte reaction assays. Given that mouse and human cDC2 subsets include subpopulations such as cDC2a, cDC2b, inf-cDC2, and moDC, we compared the rat CD103- and CD103+ cDC2 subsets to these subpopulations. The rat CD103- cDC2s expressed markers associated with cDC2a, cDC2b, inf-cDC2, and moDC, whereas the rat CD103+ cDC2s expressed exclusively cDC2a markers. These findings suggest that a substantial and potent population of DCs may have been overlooked in studies relying on anti-CD103 criteria. Researchers working with rat models should consider the presence of CD103- cDC2s in their investigations., False, Domestic journal

Educational activity

Teaching Experience

• 99 Dec. 2019, Health Science (class in English), International Christian University
• 20 Apr. 2015, Brain Anatomy, The University of Tokyo, Faculty of Medicine
• 20 Apr. 2006, Histology, The University of Tokyo, Faculty of Medicine
• 20 Apr. 2006, Human Anatomy, The University of Tokyo, Faculty of Medicine