Researchers Database
UETA HISASHI
Position： Associate Professor | |||
Last Updated :2025/07/18
Profile and Settings
Degree
Research Interests
Research Experience
- 01 Apr. 2021, Dokkyo Medical University, Department of Anatomy, Associate Professor, Japan
- 01 Apr. 2017, 31 Mar. 2021, Dokkyo Medical University, Department of Anatomy (Macro), Associate Professor, Japan
- 01 May 2013, 30 Apr. 2014, Massachusetts General Hospital, Center for Immunology and Inflammatory Diseases, Visiting Researcher, United States
Committee Memberships
Research achievements
Awards
- 22 Apr. 2021, International Immunology, Editor's Choice, Suppression of liver transplant rejection by anti-donor MHC antibodies via depletion of donor immunogenic dendritic cells., Author, Official journal
- 2020, Author, Japan society
- 2020, Japan Society of Immunology, Best Presentation Award, Novel DC targeting by allogenic T-cells for multifocal prophylactic antibody production, Ueta H, Kitazawa Y, Sawanobori Y, Katakai T, Ueha S, Matsushima K, Tokuda N, Matsuno K, Author, Japan society
- 2019, Dokkyo Medical Fundation, Representative of Institution, Publisher
- 2018, International Immunology, Editor's Choice, Rapid immunosurveillance by recirculating lymphocytes in the rat intestine: critical role of unsulfated sialyl-Lewis X on high endothelial venules of the Peyer's patches., Uchida T*, Ueta H*, Xu XD, Hirakawa J, Tahara K, Zhou S, Sawanobori Y, Simmons S, Kitazawa Y, Kawashima H, Matsuno K, Author, Publisher
- 22 Mar. 2023, Representative of Institution, Others
- 15 May 2023, Representative of Institution
- 07 Jun. 2025, Author, Japan society, Japan
Published Papers
- Extracellular ATP limits homeostatic T cell migration within lymph nodes, Kobayashi D, Sugiura Y, Umemoto E, Takeda A, Ueta H, Hayasaka H, Matsuzaki S, Katakai T, Suematsu M, Hamachi I, Yegutkin GG, Salmi M, Jalkanen S, Miyasaka M, Frontiers in Immunology, 22 Dec. 2021
- Selective involution of thymic medulla by cyclosporine A with a decrease of mature thymic epithelia, XCR1+ dendritic cells, and epithelium-free areas containing Foxp3 + thymic regulatory T cells, Yasushi Sawanobori, Yusuke Kitazawa, Hisashi Ueta, Kenjiro Matsuno, Nobuko Tokuda, Histochemistry and Cell Biology, 16 May 2021
- Suppression of liver transplant rejection by anti-donor MHC antibodies via depletion of donor immunogenic dendritic cells., Ueta H, Xu XD, Yu B, Kitazawa Y, Yu E, Hara Y, Morita-Nakamura M, Zhou S, Sawanobori Y, Ueha S, Rokutan K, Tanaka T, Tokuda N, Matsushima K, Matsuno K, International Immunology, 33(5), 261-272, 22 Apr. 2021
- Monotherapy With Anti-CD70 Antibody Causes Long-Term Mouse Cardiac Allograft Acceptance With Induction of Tolerogenic Dendritic Cells., Zhao Jing;Que Weitao;Du Xiaoxiao;Fujino Masayuki;Ichimaru Naotsugu;Ueta Hisashi;Tokuda Nobuko;Guo Wen-Zhi;Zabrocki Piotr;de Haard Hans;Nonomura Norio;Li Xiao-Kang, Frontiers in Immunology, 11, 555996, 19 Feb. 2021
- Novel Targeting to XCR1+ Dendritic Cells Using Allogeneic T Cells for Polytopical Antibody Responses in the Lymph Nodes., Kitazawa Yusuke;Ueta Hisashi;Sawanobori Yasushi;Katakai Tomoya;Yoneyama Hiroyuki;Ueha Satoshi;Matsushima Kouji;Tokuda Nobuko;Matsuno Kenjiro, Frontiers in Immunology, 10, 1195, 29 May 2019
- Visualizing the Rapid and Dynamic Elimination of Allogeneic T Cells in Secondary Lymphoid Organs., Kanda Yasuhiro;Takeuchi Arata;Ozawa Madoka;Kurosawa Yoichi;Kawamura Toshihiko;Bogdanova Dana;Iioka Hidekazu;Kondo Eisaku;Kitazawa Yusuke;Ueta Hisashi;Matsuno Kenjiro;Kinashi Tatsuo;Katakai Tomoya, Journal of Immunology (Baltimore, Md. : 1950), 201(3), 1062-1072, 01 Aug. 2018
- Rapid immunosurveillance by recirculating lymphocytes in the rat intestine: critical role of unsulfated sialyl-Lewis X on high endothelial venules of the Peyer's patches., Uchida Tomomi;Ueta Hisashi;Xu Xue-Dong;Hirakawa Jotaro;Tahara Kazunori;Zhou Shu;Sawanobori Yasushi;Simmons Szandor;Kitazawa Yusuke;Kawashima Hiroto;Matsuno Kenjiro, International immunology, 30(1), 23-33, 03 Feb. 2018
- Anatomical basis for simultaneous block of greater and third occipital nerves, with an ultrasound-guided technique., Kariya Ken;Usui Yosuke;Higashi Naoko;Nakamoto Tatsuo;Shimbori Hironobu;Terada Satoshi;Takahashi Hideo;Ueta Hisashi;Kitazawa Yusuke;Sawanobori Yasushi;Okuda Yasuhisa;Matsuno Kenjiro, Journal of anesthesia, 32(4), 483-492, 2018
- Graft-Versus-Host Disease Following Liver Transplantation: Development of a High-Incidence Rat Model and a Selective Prevention Method., Yu E*, Ueta H*, Kimura H, Kitazawa Y, Sawanobori Y, Matsuno K, American Journal of Transplantation, 17(4), 979-991, Apr. 2017
- Splenic differentiation and emergence of CCR5+CXCL9+CXCL10+ monocyte-derived dendritic cells in the brain during cerebral malaria., Hirako IC, Ataide MA, Faustino L, Assis PA, Sorensen EW, Ueta H, Araujo NM, Menezes GB, Luster AD, Gazzinelli RT, Nature Communication, 7, 13277, 03 Nov. 2016
- Direct evidence for activated CD8+ T cell transmigration across portal vein endothelial cells in liver graft rejection., Kariya Taro;Ueta Hisashi;Xu Xue-Dong;Koga Daisuke;Ezaki Taichi;Yu Enqiao;Kusumi Satoshi;Kitazawa Yusuke;Sawanobori Yasushi;Ushiki Tatsuo;Issekutz Thomas;Matsuno Kenjiro, Journal of Gastroenterology, 51(10), 985-998, Oct. 2016
- Pivotal role of duct epithelia in salivary gland GVHD., Sasaki M, Sawanobori S, Tanaka T, Kikuta, Ueta H, Kitazawa Y, Matsuno K, Arch Histol Cytol., 76(1), 1-8, Jan. 2016
- A novel multicolor immunostaining method using ethynyl deoxyuridine for analysis of in situ immunoproliferative response., Kitazawa Y, Ueta H, Hunig T, Sawanobori Y, Matsuno K, Histochemistry and Cell Biology, 144(3), 195-208, Sep. 2015
- Three distinct subsets of thymic epithelial cells in rats and mice defined by novel antibodies., Sawanobori Y, Ueta H, Dijkstra CD, Park CG, Satou M, Kitazawa Y, Matsuno K, PLoS ONE, 9(10), e109995, Oct. 2014
- Role of uterine contraction in regeneration of the murine postpartum endometrium., Yoshii A, Kitahara S, Ueta H, Matsuno K, Ezaki T, Biol Reprod., 91(2), 32, Sep. 2014
- Two immunogenic passenger dendritic-cell subsets in the rat liver have distinct trafficking patterns and radiosensitivities., Yu B*, Ueta H*, Kitazawa Y, Tanaka T, Adachi K, Kimura H, Morita M, Sawanobori Y, Qian HX, Kodama T, Matsuno K, Hepatology., 56(4), 1532-1545, Oct. 2012
- Generation of anti-human DEC205/CD205 monoclonal antibodies that recognize epitopes conserved in different mammals., Park CG, Rodriguez A, Ueta H, Lee H, Pack M, Matsuno K, Steinman RM, J Immunol Methods., 377(1-2), 15-22, Mar. 2012
- Utility of nano-sized, water-in-oil emulsion as a sustained release formulation of glycyrrhizin., Koga K, Nishimon Y, Ueta H, Matsuno K, Takada K, Biol Pharm Bull., 34(2), 300-305, 2011
- Simultaneous immunohistochemical detection of gangliosides and neuronal markers in paraformaldehyde-fixed nervous tissues by acetone etching., Sakumoto Y, Ueta H, Yuki N, Matsuno K., Arch Histol Cytol., 72(2), 77-90, Jul. 2009
- Systemic transmigration of allosensitizing donor dendritic cells to host secondary lymphoid organs after rat liver transplantation., Ueta H, Shi C, Miyanari N, Xu XD, Zhou S, Yamashita M, Ezaki T, Matsuno K, Hepatology., 47(4), 1352-1362, Apr. 2008
- Trafficking of recirculating lymphocytes in the rat liver: rapid transmigration into the portal area and then to the hepatic lymph., Xu XD, Ueta H, Zhou S, Shi C, Koga D, Ushiki T, Matsuno K, Liver Int., 28(3), 319-330, Mar. 2008
- Predominant donor CD103+CD8+ T cell infiltration into the gut epithelium during acute GvHD: a role of gut lymph nodes., Zhou S, Ueta H, Xu XD, Shi C, Matsuno K, Int Immunol., 20(3), 385-394, Mar. 2008
- Localization of enolase in synaptic plasma membrane as an alphagamma heterodimer in rat brain., Ueta H, Nagasawa H, Oyabu-Manabe Y, Toida K, Ishimura K, Hori H., Neurosci Res., 48(4), 379-386, Apr. 2004
- Temporal and spatial dynamics of immune cells in spontaneous liver transplant tolerance., Que W, Ueta H, Hu X, Morita-Nakagawa M, Fujino M, Ueda D, Tokuda N, Huang W, Guo WZ, Zhong L, Li XK., iScience, 26(9), 2023
- Newly Found Rat CD103 - Dendritic Cells Represent a Highly Immunogenic Subpopulation of Type-2 Conventional Dendritic Cells, Corresponding to Known Dendritic Cell Subsets in Mice and Humans, Yasushi Sawanobori, Tadayuki Ogawa, Hisashi Ueta, Yusuke Kitazawa, Nobuko Tokuda, Immunology, 174(4), 384-401, 04 Jan. 2025
Original paper
- 78(6), 744-750, Jun. 2019
- 37(10), 1088-1091, Oct. 2017
- 49(4), 161-164, Apr. 2017
- 259(5), 453-458, Oct. 2016
- Preventing rejection of transplanted organs through the morphology-based microenvironment research., H.Ueta, N.Tokuda, Acta Anatomica Nipponica, 99(1), 7-10, Mar. 2024
Review paper
- 47(2), Jul. 2020
- A New Multicolor Immunostaining Method for analysis of Immunoproliferative Response, Kitazawa Y, Ueta H, Sawanobori Y, Yu E, Kariya T, Sasaki M, Uchida T, Kariya K, Sakumoto J, Sasaki K, Yamada Y, Matsund K, Dokkyo Journal of Medical Sciences, 43((1)), 91-103, Mar. 2016
- The Immunotherapy mediated by Dendritic-Cells, Matsuno K, Ueta H, Sawanobori Y, Kitazawa Y, Yu E, Dokkyo Journal of Medical Sciences, 41((3)), 245-255, 2014
- Migration pathways for graft-derived dendritic-cell subsets after rat liver transplantation, Ueta H, Yu B, Matsuno K, Japanese Journal of Lymphology, 36((1)), 18-22, Jun. 2013
- 47((1)), 33-37, 2012
- The microstructure of secondary lymphoid organs that support immune cell trafficking., Matsuno K, Ueta H, Shu Z, Xue-Dong X, Sawanobori Y, Kitazawa Y, Bin Y, Yamashita M, Shi C, Arch Histol Cytol., 73(1), 1-21, 2010
- Trafficking and role of dendritic cells in the liver, Ueta H, Matsuno K, KAN TAN SUI, 58((2)), 193-199, Apr. 2009
- 32((2)), 63-66, 2009
- 9, 63-67, 2008
- Liver DC, functional subsets and trafficking, Ueta H, Matsuno K, Experimental Medicine, 26((20)), 121-127, 2008
- Localization and trafficking of immunocompetent cells, Ueta H, Matsuno K, KAN TAN SUI, 52((4)), 499-508, Apr. 2006
- 13((4)), 413-418, 2005
- 37((13)), 550-554, 2005
Other
Books etc
- Introduction to the Human Body, Contributor, Gerard J. Tortora, Bryan Derrickson, 30 Aug. 2020, 670, 434-461, Not refereed, Japanese, Textbook, Domestic journal, 978-4-621-30539-3
- Joint translation, Nov. 2018, 289-318, 978-4-621-30339-9
Presentations
- Suppression of hepatic allograft rejection by depleting donor immunogenic dendritic cells: implication of donor-specific transfusion, Ueta H, Kitazawa Y, Sawanobori Y, Matsuno K, Tokuda N, 08 Dec. 2021, 08 Dec. 2021, 12 Dec. 2021, Poster presentation, Japan Society of Immunology, Japan, False, Domestic journal
- Transmigration of activated CD8+ T-cell across the portal vein during hepatic allograft rejection, Ueta H, Kariya T, Kitazawa Y, Sawanobori Y, Matsuno K, Dec. 2016, Oral presentation, Japan Society of Immunology, False
- Area-specific M2-macrophage differentiation by recruited monocytes in rat duct-ligation acute pancreatitis model, Ueta H, Yu E, Goto M, Kitazawa Y, Sawanobori Y, Matsuno K, Jun. 2016, Poster presentation, International Symposium on Molecular Cell Biology of Macrophages, False
- Role of lymph-derived extracellular vesicles and area-specific Foxp3+ cells in the pathogenesis of Ulcerative Colitis, Hisashi Ueta, Mina Shirabe, Yusuke Kitazawa, Yasushi Sawanobori, Nobuko Tokuda, 22 Mar. 2024, 21 Mar. 2024, 23 Mar. 2024, Oral presentation, False, Domestic journal
- Role of niche-specific Foxp3+ cell and lymph extracellular vesicles in the pathogenesis of Ulcerative Colitis, Hisashi Ueta, Toshiya Tanaka, Hidefumi Kojima, Keiichi Tominaga, Yusuke Kitazawa, Yasushi Sawanobori, Mina Shirabe, Atsushi Irisawa, Nobuko Tokuda, 19 Jan. 2024, 17 Jan. 2024, 19 Jan. 2024, Poster presentation
- Rat CD103-MHCII+CD45R-CD161+CD172a+ cells are a novel potent subpopulation of cDC2, corresponding to known mouse and human subpopulations., Yasushi Sawanobori, Tadayuki Ogawa, Hisashi Ueta, Yusuke Kitazawa, Nobuko Tokuda, APPW2025, 19 Mar. 2025, 17 Mar. 2025, 19 Mar. 2025, Oral presentation, Chiba, Japan, Japan, Dendritic cells (DCs) are known for their potent capabilities in antigen presentation, T cell priming, and cytokine secretion. They consist of XCR1+ conventional DC1 (cDC1), CD172a+ cDC2, and plasmacytoid DC subsets. While CD11c serves as the primary marker for DCs in mice and humans, rat DCs have traditionally been identified by CD103 molecules. However, this history cannot exclude the possibility of CD103- DC existence in rats. To investigate this possibility, we examined low-density cells from the rat spleen and MHCII-enriched rat thymic cells, finding CD103-MHCII+CD45R-CD161+CD172a+ cells. These cells were negative for CD103 and the B cell marker CD45R, but positive for another rat DC marker CD161 and the cDC2 marker CD172a. For further characterization, we performed microarray analyses on these cells. Principal component analysis, marker gene expression, and similarity to murine counterparts indicated that these cells represent a subpopulation of cDC2. Consequently, we designated this novel subset and the classic rat cDC2 as CD103- cDC2 and CD103+ cDC2, respectively. Subsequently, we investigated the functionality of the rat CD103- and CD103+ cDC2 subsets. Gene set enrichment analyses suggested that the rat CD103- cDC2 subsets are enriched for immune-associated terms, while the rat CD103+ cDC2 subsets are enriched for cell cycle-associated terms. Consistent with this prediction, the rat CD103- cDC2 cells induced enhanced T cell proliferation in mixed lymphocyte reaction assays. Given that mouse and human cDC2 subsets include subpopulations such as cDC2a, cDC2b, inf-cDC2, and moDC, we compared the rat CD103- and CD103+ cDC2 subsets to these subpopulations. The rat CD103- cDC2s expressed markers associated with cDC2a, cDC2b, inf-cDC2, and moDC, whereas the rat CD103+ cDC2s expressed exclusively cDC2a markers. These findings suggest that a substantial and potent population of DCs may have been overlooked in studies relying on anti-CD103 criteria. Researchers working with rat models should consider the presence of CD103- cDC2s in their investigations., False, Domestic journal
- A single-cell analysis revealed tissue-restricted antigen-expressing fibroblasts accumulated in epithelium-free areas in rat thymic medulla, Yasushi Sawanobori, Hisashi Ueta, Yusuke Kitazawa, and Nobuko Tokuda, The 53rd Annual Meeting of the Japanese Society for Immunology, 03 Dec. 2024, 03 Dec. 2024, 05 Dec. 2024, Oral presentation, Nagasaki, Japan, Japan, Several reports have indicated that not only medullary thymic epithelial cells (mTECs) but also thymic medullary fibroblasts (mFbs) express tissue-restricted antigens (TRAs) that are essential for the negative selection (Nitta 2020, Nitta 2021). On the other hand, we have reported that there are medullary epithelium-free areas (mEFAs) that lack mTECs in the medulla of rat thymus (Sawanobori 2014, Sawanobori 2021). We recently performed immunohistochemistry upon some candidate antigens to reveal accumulated cells in the mEFAs, finding the accumulation of PDGFRb+ fibroblasts in this area. Based on these facts, we performed a single-cell RNA-seq (scRNA-seq) analysis on rat thymic stromal cells to investigate whether the rat mEFAs are the place to present TRAs expressed by mFbs. The umap clustering revealed five fibroblast subsets: Fb1-4s and capsular fibroblasts (capFbs). Fb1s and Fb2s expressed Pdgfra mainly. Fb3s and Fb4s expressed Pdgfrb and significant TRA genes, suggesting that they are the mFbs accumulated in the rat mEFAs. The velocity analysis revealed that Fb1s are an independent cluster, Fb2s are progenitors of capFbs, and Fb3s are the progenitors of Fb4s. Our research has demonstrated that TRA-expressing PDGFRb+ Fbs accumulate in the rat mEFAs, suggesting that mEFAs are where Fb-derived TRA are presented. Moreover, we have discovered novel fibroblast subsets: Pdgfra+ Fb1s and capFb progenitor Fb2s. Now, investigations into functions and localizations of these novel subsets are ongoing. An additional remark: The scRNA-seq also revealed subpopulations of rat mTECs that have been poorly understood. Data concerning mTECs will also be presented., False, Domestic journal
学内助成金
- 01 Apr. 2023, 31 Mar. 2024, 1000000
- 01 Apr. 2021, 31 Mar. 2022, 1000000
- 01 Apr. 2019, 31 Mar. 2021, 2000000
- 01 Apr. 2012, 31 Mar. 2013, 1000000
- 01 Apr. 2008, 31 Mar. 2009, 1000000