TAKEI GEN

Profiles

Profiles

• 氏名

  TAKEI GEN

Affiliation

• Department of Pharmacology and Toxicology, Senior Assistant Professor

Research achievements

Published Papers

Original paper
• Hamster spermatozoa incorporate hypotaurine via TauT for self-protection., Takei Gen L;Horibata Yasuhiro;Toyama Fubito;Hayashi Keitaro;Morita Asuka;Ouchi Motoshi;Fujita Tomoe, Reproduction (Cambridge, England), 168(2), 02 Jul. 2024

  DOI
• Hamster Sperm Possess Functional Na+/Ca2+-Exchanger 1: Its Implication in Hyperactivation., Takei Gen L;Ogura Yuhei;Ujihara Yoshihiro;Toyama Fubito;Hayashi Keitaro;Fujita Tomoe, International journal of molecular sciences, 24(10), 17 May 2023

  DOI
• Activation of cAMP-dependent phosphorylation pathways is independent of ROS production during mouse sperm capacitation., Takei Gen L;Tourzani Darya A;Paudel Bidur;Visconti Pablo E, Molecular reproduction and development, 88(8), 544-557, 27 Jul. 2021

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• Oviductal high concentration of K+ suppresses hyperpolarization but does not prevent hyperactivation, acrosome reaction and in vitro fertilization in hamsters., Takei Gen L;Kon Hiroe, Zygote (Cambridge, England), 29(1), 66-74, Feb. 2021

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• Na+/K+-ATPase α4 regulates sperm hyperactivation while Na+/K+-ATPase α1 regulates basal motility in hamster spermatozoa., Takei Gen L;Hayashi Keitaro, Theriogenology, 157, 48-60, 30 Jul. 2020

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• Fujinoki Masakatsu;Takei Gen L, The Journal of reproduction and development, 63(1), 67-74, 16 Feb. 2017

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• Regulatory mechanisms of sperm flagellar motility by metachronal and synchronous sliding of doublet microtubules., Takei Gen L;Fujinoki Masakatsu;Yoshida Kaoru;Ishijima Sumio, Molecular human reproduction, 23(12), 817-826, 2017

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• Regulation of hamster sperm hyperactivation by extracellular Na., Takei Gen L;Fujinoki Masakatsu, Reproduction (Cambridge, England), 151(6), 589-603, 2016

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• 182, 84-92, 2015

  DOI
• Estrogen suppresses melatonin-enhanced hyperactivation of hamster spermatozoa., Fujinoki Masakatsu;Takei Gen L, The Journal of reproduction and development, 61(4), 287-295, 11 May 2015

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• Glycolysis plays an important role in energy transfer from the base to the distal end of the flagellum in mouse sperm., Takei Gen L;Miyashiro Daisuke;Mukai Chinatsu;Okuno Makoto, The Journal of experimental biology, 217(Pt 11), 1876-1886, 27 Feb. 2014

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• Suppression of progesterone-enhanced hyperactivation in hamster spermatozoa by γ-aminobutyric acid., Kon Hiroe;Takei Gen L;Fujinoki Masakatsu;Shinoda Motoo, The Journal of reproduction and development, 60(3), 202-209, 10 Mar. 2014

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• Takei Gen L;Mukai Chinatsu;Okuno Makoto, The Journal of experimental biology, 215(Pt 4), 630-641, 15 Feb. 2012

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Review paper
• Molecular mechanisms of mammalian sperm capacitation, and its regulation by sodium-dependent secondary active transporters., Takei Gen L, Reproductive medicine and biology, 23(1), e12614, 16 Oct. 2024

  DOI
• [Regulation of sperm hyperactivation by transporters involved in Na+ homeostasis]., L Takei Gen, Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 157(3), 176-180, 2022

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• Non-genomic regulation and disruption of spermatozoal in vitro hyperactivation by oviductal hormones., The journal of physiological sciences : JPS, 66(3), 207-212, May 2016

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Unclear
• Regulation of salmonid fish sperm motility by osmotic shock-induced water influx across the plasma membrane., Takei Gen Leon;Mukai Chinatsu;Okuno Makoto, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 182, 84-92, 16 Dec. 2014

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Presentations

• Hypotaurine, a precursor of taurine, protects spermatozoa from ROS to ensure capacitation/fertilization in vivo., Gen L. Takei, 20 Jun. 2025, 20 Jun. 2024, 21 Jun. 2024, Invited oral presentation, False, Domestic journal
• Hypotaurine is synthesized and secreted in the epididymis and the oviduct to protect spermatozoa in hamsters., Gen L. Takei, Yasuhiro Horibata, Hiroe Kon, Keitaro Hayashi and Tomoe Fujita, APPW2025, Mar. 2025, 17 Mar. 2025, 19 Mar. 2025, Poster presentation
• -closed meeting-, Gordon Research Conference Fertilization & Activation of Development,, Jul. 2019, Poster presentation, True, International journal
• Signaling pathways involved in reactive oxygen species (ROS) generation during capacitation, 2. Gen L. Takei and Pablo Visconti, American Society of Andrology 44th Annual Conference, Apr. 2019, Poster presentation, United States, True, International journal
• 4th World Congress of Reproductive Biology, Sep. 2017, Poster presentation, True, Domestic journal
• closed meeting, Gordon Research Conference Fertilization & Activation of Development, Jul. 2017, Poster presentation, True, Domestic journal

学内助成金

• 2013, 2013, 500000
• 01 Apr. 2020, 31 Mar. 2021, 500000