HARA KENJI

Profiles

Profiles

• 氏名

  HARA KENJI

Affiliation

• Department of Diabetes, Endocrinology and Hematology

Research achievements

Published Papers

Original paper
• Association between angiopoietin-like protein 2 and lectin-like oxidized low-density lipoprotein receptor 1 ligand containing apolipoprotein B in patients with type 2 diabetes, Suzuki T, Takebayashi KHara KTsuchiya TInukai T, J Int Med Res, 46(10), 4167-4180, Oct. 2018

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• Isolated Adrenocorticotropic Hormone Deficiency and Severe Hypercalcemia After Destructive Thyroiditis in a Patient on Nivolumab Therapy With a Malignant Melanoma, Takebayashi K, Ujiie AKubo MFurukawa SYamauchi MShinozaki HSuzuki TNaruse RHara KTsuchiya TInukai T, J Clin Med Res, 10(4), 358-362, Apr. 2018

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• Involvement of Resveratrol and omega-3 Polyunsaturated Fatty Acids on Sirtuin 1 Gene Expression in THP1 Cells, Tsuchiya T, Endo ATsujikado KInukai T, Am J Med Sci, 354(4), 415-422, Oct. 2017

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• Effect of canagliflozin on circulating active GLP-1 levels in patients with type 2 diabetes: a randomized trial, Takebayashi K, Hara KTerasawa TNaruse RSuetsugu MTsuchiya TInukai T, Endocr J, 64(9), 923-931, Sep. 2017

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• Serum Betatrophin Levels and Clinical Features in Patients With Poorly Controlled Type 2 Diabetes, Takebayashi K, Hara KTerasawa TNaruse RSuetsugu MTsuchiya TInukai T, J Clin Med Res, 9(9), 782-787, Sep. 2017

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• Long-Term Effect of Alogliptin on Glycemic Control in Japanese Patients With Type 2 Diabetes: A 3.5-Year Observational Study, Takebayashi K, Suzuki TNaruse RHara KSuetsugu MTsuchiya TInukai T, J Clin Med Res, 9(9), 802-808, Sep. 2017

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• Circulating SerpinB1 levels and clinical features in patients with type 2 diabetes, Takebayashi K, Hara K, Terasawa TNaruse RSuetsugu MTsuchiya TInukai T, BMJ Open Diabetes Res Care, 4(1), e000274, 2016

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• 50(3), 659-664, Dec. 2015

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• Sitagliptin, a DPP-4 inhibitor, alters the subsets of circulating CD4+ T cells in patients with type 2 diabetes, Aso Y, Fukushima MSagara MJojima TIijima TSuzuki KMomobayashi AKasai KInukai T, Diabetes Res Clin Pract, 110(3), 250-256, Dec. 2015

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• Effect of proton pump inhibitors on glycemic control in patients with diabetes, Takebayashi K, Inukai T, World J Diabetes, 6(10), 1122-1131, Aug. 2015

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• Bezafibrate, a peroxisome proliferator-activated receptor alpha agonist, decreases circulating CD14(+)CD16(+) monocytes in patients with type 2 diabetes, Terasawa T, Aso YOmori KFukushima MMomobayashi AInukai T, Transl Res, 165(2), 336-345, Feb. 2015

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• Alterations of plant sterols, lathosterol, oxidative stress and inflammatory markers after the combination therapy of ezetimibe and statin drugs in type 2 diabetic patients, Naruse R, Hori KTerasawa THara KSuetsugu MTakebayashi KMorita KAso YInukai T, Obes Res Clin Pract, 9(1), 67-74, Jan. 2015

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• Effect of combination therapy with alogliptin and lansoprazole on glycemic control in patients with type 2 diabetes, Takebayashi K, Sakurai SSuzuki THori KTerasawa TNaruse RHara KSuetsugu MTsuchiya TAoki HHamasaki TShuutou HInukai T, Endocr J, 61(10), 1031-1039, 2014
• The serum level of soluble CD26/dipeptidyl peptidase 4 increases in response to acute hyperglycemia after an oral glucose load in healthy subjects: association with high-molecular weight adiponectin and hepatic enzymes, Aso Y, Terasawa TKato KJojima TSuzuki KIijima TKawagoe YMikami SKubota YInukai TKasai K, Transl Res, 162(5), 309-316, Nov. 2013

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• Association of the Hermansky-Pudlak syndrome type 4 (HPS4) gene variants with cognitive function in patients with schizophrenia and healthy subjects, Kuratomi G, Saito AOzeki YWatanabe TFujii KShimoda KInukai TMori HOhmori KAkiyama K, BMC Psychiatry, 13, 276, Oct. 2013

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• An association study of the Hermansky-Pudlak syndrome type 4 gene in schizophrenic patients, Saito A, Kuratomi GIto CMatsuoka HSuzuki TOzeki YWatanabe TFujii KShimoda KFukushima YInukai TOhmori KAkiyama K, Psychiatr Genet, 23(4), 163-73, Aug. 2013

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• Oxidative stress and antioxidative potency are closely associated with diabetic retinopathy and nephropathy in patients with type 2 diabetes, Naruse R, Suetsugu MTerasawa TIto KHara KTakebayashi KMorita KAso YInukai T, Saudi Med J, 34(2), 135-141, Feb. 2013
• Spontaneous platelet aggregation evaluated by laser light scatter in patients with type 2 diabetes: effects of short-term improved glycemic control and adiponectin, Hara K, Omori KSumioka YAso Y, Transl Res, 159(1), 15-24, Jan. 2012

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• Serum level of soluble CD26/dipeptidyl peptidase-4 (DPP-4) predicts the response to sitagliptin, a DPP-4 inhibitor, in patients with type 2 diabetes controlled inadequately by metformin and/or sulfonylurea, Aso Y, Ozeki NTerasawa TNaruse RHara KSuetsugu MTakebayashi KShibazaki MHaruki KMorita KInukai T, Transl Res, 159(1), 25-31, Jan. 2012

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• Relationship of body fat weight and body fat ratio determined by bioelectric impedance to serum adipocytokines in patients with type 2 diabetes mellitus, Naruse R, Inukai YTerasawa THara KTakebayashi KMorita MAso YInukai T, Obes Res Clin Pract, 5(4), e267-e360, Oct. 2011

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• Effects of retinol binding protein-4 on vascular endothelial cells, Takebayashi K, Sohma RAso YInukai T, Biochem Biophys Res Commun, 408(1), 58-64, Apr. 2011

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• Comparison of effects of insulin aspart three times a day versus insulin detemir once a day on oxidative stress in patients with type 2 diabetes, Naruse R, Takebayashi KMorita KAso YInukai T, Endocr J, 58(12), 1055-1063, 2011
• Determinants of serum high molecular weight (HMW) adiponectin levels in patients with coronary artery disease: associations with cardio-renal-anemia syndrome, Hara K, Uchida TTakebayashi KSakai YInoue TInukai TTakayanagi KAso Y, Intern Med, 50(24), 2953-2960, 2011
• Relation between serum high molecular weight adiponectin and serum ferritin or prohepcidin in patients with type 2 diabetes, Aso Y, Takebayashi KWakabayashi SMomobayashi ASugawara NTerasawa TNaruse RHara KSuetsugu MMorita KInukai T, Diabetes Res Clin Pract, 90(3), 250-255, Dec. 2010

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• Role of bile acid sequestrants in the treatment of type 2 diabetes, Takebayashi K, Aso YInukai T, World J Diabetes, 1(5), 146-152, Nov. 2010

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• Anemia is associated with an elevated serum level of high-molecular-weight adiponectin in patients with type 2 diabetes independently of renal dysfunction, Aso Y, Suganuma RWakabayashi SHara KNakano TSuetsugu MMatsumoto SNakamachi TTakebayashi KMorita KInukai T, Transl Res, 154(4), 175-182, Oct. 2009

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• Serum high-molecular weight adiponectin decreases abruptly after an oral glucose load in subjects with normal glucose tolerance or impaired fasting glucose, but not those with impaired glucose tolerance or diabetes mellitus, Ozeki N, Hara KYatsuka CNakano TMatsumoto SSuetsugu MNakamachi TTakebayashi KInukai THaruki KAso Y, Metabolism, 58(10), 1470-1476, Oct. 2009

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• Low-dose pioglitazone increases serum high molecular weight adiponectin and improves glycemic control in Japanese patients with poorly controlled type 2 diabetes, Aso Y, Hara KOzeki NYatsuka CNakano TMatsumoto SSuetsugu MNakamachi TTakebayashi KHaruki KInukai T, Diabetes Res Clin Pract, 85(2), 147-152, Aug. 2009

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• Effects of rosuvastatin and colestimide on metabolic parameters and urinary monocyte chemoattractant protein-1 in type 2 diabetic patients with hyperlipidemia, Takebayashi K, Suetsugu MMatsumoto SAso YInukai T, South Med J, 102(4), 361-368, Apr. 2009

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• High-molecular-weight adiponectin does not predict cardiovascular events in patients with type 2 diabetes, Krzyzanowska K, Aso YMittermayer FInukai TBrix JSchernthaner G, Transl Res, 153(4), 199-203, Apr. 2009

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• Increase of osteopontin plasma concentrations after bariatric surgery independent from inflammation and insulin resistance, Schaller G, Aso YSchernthaner GHKopp HPInukai TKriwanek SSchernthaner G, Obes Surg, 19(3), 351-356, Mar. 2009

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• Effects of losartan on serum total and high-molecular weight adiponectin concentrations in hypertensive patients with metabolic syndrome, Uchida T, Shimizu MSakai YNakano THara KTakebayashi KInoue TNode KInukai TTakayanagi KAso Y, Metabolism, 57(9), 1278-1285, Sep. 2008

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• High molecular weight adiponectin as a predictor of long-term clinical outcome in patients with coronary artery disease, Inoue T, Kotooka NMorooka TKomoda HUchida TAso YInukai TOkuno TNode K, Am J Cardiol, 100(4), 569-574, Aug. 2007

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• Retinol binding protein-4 levels and clinical features of type 2 diabetes patients, Takebayashi K, Suetsugu MWakabayashi SAso YInukai T, J Clin Endocrinol Metab, 92(7), 2712-2719, Jul. 2007

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• PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes, Nakamachi T, Nomiyama TGizard FHeywood EBJones KLZhao YFuentes LTakebayashi KAso YStaels BInukai TBruemmer D, Diabetes, 56(6), 1662-1670, Jun. 2007

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• Association between plasma visfatin and vascular endothelial function in patients with type 2 diabetes mellitus, Takebayashi K, Suetsugu MWakabayashi SAso YInukai T, Metabolism, 56(4), 451-458, Apr. 2007

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• High serum high-sensitivity C-reactive protein concentrations are associated with relative cardiac sympathetic overactivity during the early morning period in type 2 diabetic patients with metabolic syndrome, Aso Y, Wakabayashi SNakano TYamamoto RTakebayashi KInukai T, Metabolism, 55(8), 1014-21, Aug. 2006

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• Comparison of serum high-molecular weight (HMW) adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin, Aso Y, Yamamoto RWakabayashi SUchida TTakayanagi KTakebayashi KOkuno TInoue TNode KTobe TInukai TNakano Y, Diabetes, 55(7), 1954-1960, Jul. 2006

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• Aldosterone blockade attenuates urinary monocyte chemoattractant protein-1 and oxidative stress in patients with type 2 diabetes complicated by diabetic nephropathy, Takebayashi K, Matsumoto SAso YInukai T, J Clin Endocrinol Metab, 91(6), 2214-2217, Jun. 2006

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• Profound reduction in T-helper (Th) 1 lymphocytes in peripheral blood from patients with concurrent type 1 diabetes and Graves' disease, Aso Y, Matsuura HMomobayashi AInukai YSugawara NNakano TYamamoto RWakabayashi STakebayashi KInukai T, Endocr J, 53(3), 377-385, Jun. 2006
• Association between circulating monocyte chemoattractant protein-1 and urinary albumin excretion in nonobese Type 2 diabetic patients, Takebayashi K, Matsumoto SAso YInukai T, J Diabetes Complications, 20(2), 98-104, Mar. 2006

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• Relationships between heart rate variability and urinary albumin excretion in patients with type 2 diabetes, Takebayashi K, Matsutomo RMatsumoto SSuetsugu MWakabayashi SAso YInukai T, Am J Med Sci, 331(2), 72-78, Feb. 2006
• Correlation of high-sensitivity C-reactive protein and plasma fibrinogen with individual complications in patients with type 2 diabetes, Takebayashi K, Suetsugu MMatsutomo RWakabayashi SAso YInukai T, South Med J, 99(1), 23-7, Jan. 2006

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• Small low-density lipoprotein and small low-density lipoprotein/total low-density lipoprotein are closely associated with intima-media thickness of the carotid artery in Type 2 diabetic patients, Inukai T, Yamamoto RSuetsugu MMatsumoto SWakabayashi SInukai YMatsutomo RTakebayashi KAso Y, J Diabetes Complications, 19(5), 269-275, Sep. 2005

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• The effect of low-dose atorvastatin on circulating monocyte chemoattractant protein-1 in patients with type 2 diabetes complicated by hyperlipidemia, Takebayashi K, Matsumoto SWakabayashi SInukai YMatsutomo RAso YInukai T, Metabolism, 54(9), 1225-1229, Sep. 2005

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• Metabolic syndrome accompanied by hypercholesterolemia is strongly associated with proinflammatory state and impairment of fibrinolysis in patients with type 2 diabetes: synergistic effects of plasminogen activator inhibitor-1 and thrombin-activatable fibrinolysis inhibitor, Aso Y, Wakabayashi SYamamoto RMatsutomo RTakebayashi KInukai T, Diabetes Care, 28(9), 2211-2216, Sep. 2005
• Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers effectively and directly potentiate superoxide scavenging by polymorphonuclear leukocytes from patients with type 2 diabetes mellitus, Inukai T, Yoshida NWakabayashi SInukai YMatsutomo RTakanashi KNakamachi TTakebayashi KAso YTakahashi K, Am J Med Sci, 329(5), 222-227, May 2005
• Elevated pregnancy-associated plasma protein-a in sera from type 2 diabetic patients with hypercholesterolemia: associations with carotid atherosclerosis and toe-brachial index, Aso Y, Okumura KWakabayashi STakebayashi KTaki SInukai T, J Clin Endocrinol Metab, 89(11), 5713-5717, Nov. 2004

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• Coagulation and inflammation in overt diabetic nephropathy: association with hyperhomocysteinemia, Aso Y, Yoshida NOkumura KWakabayashi SMatsutomo RTakebayashi KInukai T, Clin Chim Acta, 348(1-2), 139-145, Oct. 2004

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• Association between the corrected QT intervals and combined intimal-medial thickness of the carotid artery in patients with type 2 diabetes, Takebayashi K, Aso YMatsutomo RWakabayashi SInukai T, Metabolism, 53(9), 1152-1157, Sep. 2004
• Dissociation between urinary pyrraline and pentosidine concentrations in diabetic patients with advanced nephropathy, Aso Y, Takanashi KSekine KYoshida NTakebayashi KYoshihara KInukai T, J Lab Clin Med, 144(2), 92-99, Aug. 2004

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• Initiation of insulin therapy reduces serum concentrations of high-sensitivity C-reactive protein in patients with type 2 diabetes, Takebayashi K, Aso YInukai T, Metabolism, 53(6), 693-699, Jun. 2004
• Results of blood inflammatory markers are associated more strongly with toe-brachial index than with ankle-brachial index in patients with type 2 diabetes, Aso Y, Okumura KInoue TMatsutomo RYoshida NWakabayashi STakebayashi KInukai T, Diabetes Care, 27(6), 1381-1386, Jun. 2004
• Relationships of plasma interleukin-18 concentrations to hyperhomocysteinemia and carotid intimal-media wall thickness in patients with type 2 diabetes, Aso Y, Okumura KTakebayashi KWakabayashi SInukai T, Diabetes Care, 26(9), 2622-2627, Sep. 2003
• High glucose concentrations abolish the superoxide dismutase response of leukocytes to ascorbic acid or troglitazone in type 2 diabetes mellitus, Inukai T, Takanashi KTayama KAso YTakemura Y, Life Sci, 70(20), 2391-401, Apr. 2002
• Impaired fibrinolytic compensation for hypercoagulability in obese patients with type 2 diabetes: association with increased plasminogen activator inhibitor-1, Aso Y, Matsumoto SFujiwara YTayama KInukai TTakemura Y, Metabolism, 51(4), 471-476, Apr. 2002
• 91(6), 811-814, Jun. 2014
• Seasonal variations and the influence of COVID-19 pandemic on hemoglobin A1c, glycoalbumin, and low-density lipoprotein cholesterol, Takebayashi K，Yamauchi M，Hara K，Tsuchiya T，Hashimoto K．, Diabetol Int., 13(4), 599-605, Oct. 2022
• Seasonal variations and the influence of COVID-19 pandemic on hemoglobin A1c，glycoalbumin，and low-density lipoprotein cholesterol．, Takebayashi K，Yamauchi M，Hara K，Tsuchiya T，Hashimoto K, Diabetol Int., 13(4), 599-605, Oct. 2022
• Association of skin autofluorescence with serum lipids, insulin secretion ability and diabetic complications in patients with poorly controlled type 2 diabetes., Takebayashi K, Tsuchiya T, Shinozaki H, Yamauchi M, Suzuki T, Hara K, Inukai T, Hashimoto K., Dokkyo Med J., 2022
• Switching from a dipeptidyl peptidase (DPP)-4 inhibitor to oral semaglutide in patients with poorly controlled type 2 diabetes: an observational study., Takebayashi K, Yamauchi M, Hara K, Tsuchiya T, Hashimoto K., 2022
• Analysis of five cases showing false-high Hemoglobin A1c due to reduced catalase activity., Hara K, Ujiie A, Suzuki S, Okumura T, Kubo M, Shinozaki H, Yamauchi M, Tsuchiya T, Takebayashi K, Shimozawa N, Koga M, Hashimoto K, Endocr J, 71, 39-44, 2024
• Effects of telemedicine on the management of diabetes mellitus in the COVID-19 pandemic- A single center study-., Furukawa S, Kawai S, Yamauchi M, Shinozaki H, Ujiie A, Okumura T, Kubo M, Suzuki S, Asai K, Takii H, Hara K, Miyakawa K, Hara K, Tsuchiya T, Takebayashi K, Hashimoto K, Dokkyo Med J, 2023
• Analysis of five cases showing false-high Hemoglobin A1c due to reduced catalase activity., Hara K, Ujiie A, Suzuki S, Okumura T, Kubo M, Shinozaki H, Yamauchi M, Tsuchiya T, Takebayashi K, Shimozawa N, Koga M, Hashimoto K, Endocr J., 71, 39-44, 2024
• Changing from a Dipeptidyl Peptidase (DPP)-4 Inhibitor to Oral Semaglutide in Patients with Poorly Controlled Type 2 Diabetes Mellitus: An Observational Study., Takebayashi K, Yamauchi M, Hara K, Tsuchiya T, Hashimoto K., Dokkyo Medical J., 2(Jun), 123-129, 2023

Other
• Symptomatic obesity--classification, pathogenesis, diagnosis and therapy, Inukai T, Nihon Rinsho, 71(2), 291-296, Feb. 2013
• A case presenting with ataxic gait and dementia due to vitamin B(1)(2) deficiency without megaloblastic anemia or subacute combined degeneration of the spinal cord, Iwanami H, Tanaka MIwakawa HTakiguti YInukai T, Brain Nerve, 63(3), 267-269, Mar. 2011
• Magnetic resonance imaging (MRI) of human T lymphocyte virus type I (HTLV-I) associated polyradiculoneuropathy, Iwanami H, Tatsumoto MHirata KTakiguchi YInukai T, Brain Nerve, 62(6), 633-634, Jun. 2010
• Pseudofourth nerve palsy as initial and sole presentation in ocular myasthenia, Suzuki K, Hirata KTakiguchi YHori KAso YInukai T, South Med J, 102(6), 669-670, Jun. 2009

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• Extensive callosal infarction showing difficulty in knitting as an initial symptom, Suzuki K, Takiguchi YMiyamoto TMiyamoto MHirata KHara KSuzuki STakebayashi KAso YInukai T, Intern Med, 47(15), 1431-1435, 2008
• Magnetic resonance images in rhombencephalitis due to Listeria monocytogenes mimicking Wernicke encephalopathy, Suzuki K, Takiguchi YSuzuki SHirata KInukai T, Intern Med, 47(8), 817-818, 2008
• Endogenous endophthalmitis and disseminated intravascular coagulation complicating a Klebsiella pneumoniae perirenal abscess in a patient with type 2 diabetes, Takebayashi K, Matsumoto SNakagawa YWakabayashi SAso YInukai T, Am J Med Sci, 329(3), 157-160, Mar. 2005
• Microscopic polyangiitis presenting with liver dysfunction preceding rapidly progressive necrotizing glomerulonephritis, Takebayashi K, Aso YKitamura HSakurai YWakabayashi SInukai T, South Med J, 97(9), 911-914, Sep. 2004

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• Measles encephalitis and acute pancreatitis in a young adult, Takebayashi K, Aso YWakabayashi SMatsutomo ROkumura KSugita RInukai T, Am J Med Sci, 327(5), 299-303, May 2004
• Myotonic dystrophy associated with variable circadian rhythms of serum cortisol and isolated thyrotropin deficiency, Okumura K, Aso YTayama KYoshida NTakiguchi YTakemura YInukai T, Am J Med Sci, 324(3), 158-160, Sep. 2002
• Effect of Sodium Glucose Cotransporter 2 Inhibitors With Low SGLT2/SGLT1 Selectivity on Circulating Glucagon-Like Peptide 1 Levels in Type 2 Diabetes Mellitus, Takebayashi K, Inukai T, J Clin Med Res, 9(9), 745-753, Sep. 2017

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Books etc

• Single work, 2023

Educational activity

Teaching Experience

• 2015, hyperthyroidism

Social contributions

Academic Contribution

• Apr. 2016, Apr. 2016, Not contributing to international academic