HASHIMOTO KOSHI

Profiles

Profiles

• 氏名

  HASHIMOTO KOSHI

Affiliation

• Department of Diabetes, Endocrinology and Hematology, Professor

Research achievements

Published Papers

Original paper
• Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing., Hanzawa N, Hashimoto K, Yuan X, Kawahori K, Tsujimoto K, Hamaguchi M, Tanaka T, Nagaoka Y, Nishina H, Morita S, Hatada I, Yamada T, Ogawa Y., Sci Rep, 10(1), 5181, Mar. 2020

  DOI
• Clinical outcomes of 20 Japanese patients with insulinoma treated with diazoxide., Niitsu Y, Minami I, Izumiyama H, Hashimoto K, Yoshimoto T, Sato F, Tsujino M, Ota K, Kudo A, Tanabe M, Yamada T, Ogawa Y, Endocr J, 66(2), 149-155, 01 Feb. 2019

  DOI
• Analysis of time-dependent changes in the FIB4 index in patients with obesity receiving weight reduction therapy．, Kawai S，Yamakage H，Kotani K，Noda M，Satoh-Asahara N，Hashimoto K, Sci Rep., 12(1), Sep. 2022
• Seasonal variations and the influence of COVID-19 pandemic on hemoglobin A1c，glycoalbumin，and low-density lipoprotein cholesterol．, Takebayashi K，Yamauchi M，Hara K，Tsuchiya T，Hashimoto K, Diabetol Int., 13(4), 599-605, Oct. 2022

  DOI
• Association of skin autofluorescence with serum lipids, insulin secretion ability and diabetic complications in patients with poorly controlled type 2 diabetes., Takebayashi K, Tsuchiya T, Shinozaki H, Yamauchi M, Suzuki T, Hara K, Inukai T, Hashimoto K, Dokkyo Med J., 2022
• Switching from a dipeptidyl peptidase (DPP)-4 inhibitor to oral semaglutide in patients with poorly controlled type 2 diabetes: an observational study., Takebayashi K, Yamauchi M, Hara K, Tsuchiya T, Hashimoto K., Dokkyo Med J., 2022
• In Vivo Tissue-Specific DNA Demethylation in Mouse Liver Through a Hydrodynamic Tail Vein Injection, Hashimoto K，Hanzawa N, Methods Mol Biol, 2577, 269-277, 2023

  DOI

Review paper
• Update on subclinical thyroid dysfunction, Hashimoto K．, Endocr J., 69(7), 725-738, 28 Jul. 2022
• 24(2), 6-6, Oct. 2022
• 111(5), 583-588, 01 May 2023
• 53(2), 37-42, 2023

Case report
• A case of generalized lipodystrophy-associated progeroid syndrome treated by leptin replacement with short and long-term monitoring of the metabolic and endocrine profiles., Fukaishi T, Minami I, Masuda S, Miyachi Y, Tsujimoto K, Izumiyama H, Hashimoto K, Yoshida M, Takahashi S, Kashimada K, Morio T, Kosaki K, Maezawa Y, Yokote K, Yoshimoto T, Yamada T., Endocr J, 67(2), 211-218, 01 Feb. 2020

  DOI
• A case of refractory hypothyroidism due to poor compliance treated with the weekly intravenous and oral levothyroxine administration., Nakano Y, Hashimoto K, Ohkiba N, Okuma H, Minami I, Takahashi H, Tanaka Y, Yoshimoto T, Yamada T, Case Rep Endocrinol, 2019(5), 5986014-5986014, 01 Feb. 2019

  DOI
• Severe Non-Islet Cell Hypoglycemia From Ileum-Origin Gastrointestinal Stromal Tumor Producing Insulin-Like Growth Factor-2 in a Patient With Liver Cirrhosis Due to Chronic Hepatitis B, Takebayashi K, Furukawa S, Okumura T, Kubo M, Ujiie A, Yamauchi M, Shinozaki H, Hara K, Tsuchiya T, Ono Y, Inukai T, Hashimoto K, J Clin Med Res., 12, 824-830, 18 Dec. 2020

  DOI
• A case of persistent SARS-CoV-2 PCR positive after chemotherapy for B-cell lymphoma．, Hirokawa H，Hirata H，Kitajima R，Irokawa M，Ishiguro T，Hasegawa T，Sato J， Ozaki A，Arima M，Teramoto S，Haruki K，Okamura T，Tamura H，Hashimoto K， Fukushima Y., Dokkyo Med J., 1(2), 141-146, Jun. 2022

Presentations

• Adenosine induces myeloma cell apoptosis due to decreased expression of PIM-2 and Myc, Sunakawa M，Ishibashi M，Kinoshita R，Kaito Y，Tanaka K，Akuzawa Y，Okura M， Okamura T，Kiguchi T，Hashimoto K，Tamura H, 14 Oct. 2022

Public grant (competitive fund)

• Exercise therapy against the development of diabetic kidney disease, 科学研究費助成事業(獨協医科大学, 獨協医科大学), Kenji Hara, 01 Apr. 2020 - 31 Mar. 2023
• Elucidation of molecular mechanism of epigenetic memory of FGF21 gene and its functional significance in vivo., 科学研究費助成事業(獨協医科大学), Koshi Hashimoto, 01 Apr. 2019 - 31 Mar. 2022
• reration of subclinical hypothyroidism and fetal and maternal complications, 科学研究費助成事業(独立行政法人国立病院機構(京都医療センター臨床研究センター), 独立行政法人国立病院機構(京都医療センター臨床研究センター), 獨協医科大学, 独立行政法人国立病院機構(京都医療センター臨床研究センター), 独立行政法人国立病院機構(京都医療センター臨床研究センター), 独立行政法人国立病院機構(京都医療センター臨床研究センター)), Michiko Wada, 01 Apr. 2018 - 31 Mar. 2021
• Elucidation of epigenetic control by fatty acid against metabolic syndrome, 科学研究費助成事業(大阪女子短期大学, 東京医科歯科大学), MAYUMI TAKAHASHI, Tomomi YAMAZAKI, 01 Apr. 2015 - 31 Mar. 2018
• Epigenetic analysis of gene expression in central nervous system of offspring derived from dam with hypothyroxinemia during pregnancy, 科学研究費助成事業(東京医科歯科大学, 東京医科歯科大学, 京都府立大学), Koshi Hashimoto, Yoshihiro OGAWA, Yasutomi KAMEI, Kenichi KAWAHORI, 01 Apr. 2014 - 31 Mar. 2017
• Analysis of epigenetic memory of FGF21 gene in the liver, 科学研究費助成事業(東京医科歯科大学, 東京医科歯科大学, 東京医科歯科大学), Xunmei Yuan, Koshi HASHIMOTO, Yoshihiro OGAWA, Kazutaka TSUJIMOTO, Kenichi KAWAHORI, Nozomi HANZAWA, 01 Apr. 2014 - 31 Mar. 2017
• Molecular mechanism of intracellular and in vivo function of an anorexic peptide, Nesfatin-1, 科学研究費助成事業(東京医科歯科大学), Koshi HASHIMOTO, 28 Apr. 2011 - 31 Mar. 2014
• Studies on signal activating systems induced by an anorexigenicappetitekine, Nesfatin-1, 科学研究費助成事業(群馬大学, 群馬大学, 群馬大学, 自治医科大学, 群馬大学), Masatomo MORI, Shuichi OKADA, Koshi HASHIMOTO, Toshihiko YADA, Masanobu YAMADA, 31 May 2010 - 31 Mar. 2013
• Analysis of intracellular signaling pathway of an anorexic hormone 'Nesfatin-1'., 科学研究費助成事業(群馬大学), Koshi HASHIMOTO, -
• Identification of a receptor for an anorexigenic molecule, Nesfatin-1, and its signal transduction systems, 科学研究費助成事業(群馬大学, 群馬大学, 群馬大学, 群馬大学, 群馬大学, 埼玉大学), Masatomo MOR, Hiroyuki SHIMIZU, Masanobu YAMADA, Shuichi OKADA, Kohshi HASHIMOTO, Kinji INOUE, -
• Elucidation of clinicopathological significance of Siglec1 in Graves' disease and clinical application of Siglec1, 科学研究費助成事業(獨協医科大学), 01 Apr. 2023 - 31 Mar. 2026

Social contributions

Media Coverage

• Media report, 09 Jun. 2020
• Paper, 20 May 2020
• Paper, Other than myself, 05 Mar. 2020
• Paper, 07 Nov. 2019