ITOH MASAHIKO

Profiles

Profiles

• 氏名

  ITOH MASAHIKO

Affiliation

• Department of Biochemistry, Associate Professor

Profile and Settings

Affiliation

• Dokkyo Medical University, School of Medicine

Research Areas

• Life Science, Cell biology

Research achievements

Awards

• 01 Apr. 2019, Author, Publisher, Japan

Published Papers

Original paper
• The zonula occludens protein family regulates the hepatic barrier system in the murine liver, Itoh M, Terada M, Sugimoto H, BBA Molecular Basis of Disease, 01 Jan. 2021

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• Selective expression of claudin-5 in thymic endothelial cells regulates the blood-thymus barrier and T-cell export, Nagatake T, Yan-Chun Z, Ito T, Itoh M, Kometani K, Furuse M, Saika A, Node E, Kunisawa J, Minato N, Hamazaki Y., International Immunology, 10 Oct. 2020

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• Effects of the differential expression of ZO-1 and ZO-2 on podocyte structure and function., Masahiko Itoh, Kazuhiko Nakadate, Taiji Matsusaka, Walter Hunziker, Hiroyuki Sugimoto, Genes to cells : devoted to molecular & cellular mechanisms, 23(7), 546-556, Jul. 2018

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• 123, 1777-1788, 1994

Unclear
• The exon 38-containing ARHGEF11 splice isoform is differentially expressed and is required for migration and growth in invasive breast cancer cells, Masahiko Itoh, Derek C. Radisky, Masaaki Hashiguchi, Hiroyuki Sugimoto, ONCOTARGET, 8(54), 92157-92170, Nov. 2017

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• Identification of the N-terminal transmembrane domain of StarD7 and its importance for mitochondrial outer membrane localization and phosphatidylcholine transfer, Yasuhiro Horibata, Hiromi Ando, Motoyasu Satou, Hiroaki Shimizu, Satomi Mitsuhashi, Yasuo Shimizu, Masahiko Itoh, Hiroyuki Sugimoto, SCIENTIFIC REPORTS, 7(1), 8793, Aug. 2017

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• Human Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) Regulates Dendritic Morphogenesis, Yutaka Mizuki, Manabu Takaki, Shinji Sakamoto, Sojiro Okamoto, Makiko Kishimoto, Yuko Okahisa, Masahiko Itoh, Norihito Yamada, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(1), Jan. 2017

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• StarD7 Protein Deficiency Adversely Affects the Phosphatidylcholine Composition, Respiratory Activity, and Cristae Structure of Mitochondria, Yasuhiro Horibata, Hiromi Ando, Peixiang Zhang, Laurent Vergnes, Chieko Aoyama, Masahiko Itoh, Karen Reue, Hiroyuki Sugimoto, JOURNAL OF BIOLOGICAL CHEMISTRY, 291(48), 24880-24891, Nov. 2016

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• Transcriptional suppression of CTP: phosphoethanolamine cytidylyltransferase by 25-hydroxycholesterol is mediated by nuclear factor-Y and Yin Yang 1, Hiromi Ando, Chieko Aoyama, Yasuhiro Horibata, Motoyasu Satou, Satomi Mitsuhashi, Masahiko Itoh, Kohei Hosaka, Hiroyuki Sugimoto, BIOCHEMICAL JOURNAL, 471(3), 369-379, Nov. 2015

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• The Structural and Functional Organization of the Podocyte Filtration Slits Is Regulated by Tjp1/ZO-1, Masahiko Itoh, Kazuhiko Nakadate, Yasuhiro Horibata, Taiji Matsusaka, Jianliang Xu, Walter Hunziker, Hiroyuki Sugimoto, PLOS ONE, 9(9), e106621, Sep. 2014

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• Enzymatic and transcriptional regulation of the cytoplasmic acetyl-CoA hydrolase ACOT12, Yasuhiro Horibata, Hiromi Ando, Masahiko Itoh, Hiroyuki Sugimoto, JOURNAL OF LIPID RESEARCH, 54(8), 2049-2059, Aug. 2013

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• [Molecular regulatory mechanisms of epithelial structure and barrier function]., Itoh M, Seikagaku. The Journal of Japanese Biochemical Society, 85(7), 582-585, Jul. 2013
• ARHGEF11, a regulator of junction-associated actomyosin in epithelial cells., Itoh M, Tissue barriers, 1(2), e24221, Apr. 2013

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• Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-Myosin II signaling, Masahiko Itoh, Sachiko Tsukita, Yuji Yamazaki, Hiroyuki Sugimoto, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(25), 9905-9910, Jun. 2012

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• Similar and Distinct Properties of MUPP1 and Patj, Two Homologous PDZ Domain-Containing Tight-Junction Proteins, Makoto Adachi, Yoko Hamazaki, Yuka Kobayashi, Masahiko Itoh, Sachiko Tsukita, Mikio Furuse, Shoichiro Tsukita, MOLECULAR AND CELLULAR BIOLOGY, 29(9), 2372-2389, May 2009

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• Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells, Tatsuya Katsuno, Kazuaki Umeda, Takeshi Matsui, Masaki Hata, Atsushi Tamura, Masahiko Itoh, Kosei Takeuchi, Toshihiko Fujimori, Yo-ichi Nabeshima, Tetsuo Noda, Shoichiro Tsukita, Sachiko Tsukita, MOLECULAR BIOLOGY OF THE CELL, 19(6), 2465-2475, Jun. 2008

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• Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells, Masahiko Itoh, Celeste M. Nelson, Connie A. Myers, Mina J. Bissell, CANCER RESEARCH, 67(10), 4759-4766, May 2007

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• Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein, Makoto Adachi, Akihito Inoko, Masaki Hata, Kyoko Furuse, Kazuaki Umeda, Masahiko Itoh, Shoichiro Tsukita, MOLECULAR AND CELLULAR BIOLOGY, 26(23), 9003-9015, Dec. 2006

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• Expression and distribution of ZO-3, a tight junction MAGUK protein, in mouse tissues, A Inoko, M Itoh, A Tamura, M Matsuda, M Furuse, S Tsukita, GENES TO CELLS, 8(11), 837-845, Nov. 2003

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• The organization of tight junctions in epithelia: Implications for mammary gland biology and breast tumorigenesis, M Itoh, MJ Bissell, JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 8(4), 449-462, Oct. 2003

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• Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis, K Morita, M Furuse, Y Yoshida, M Itoh, H Sasaki, S Tsukita, Y Miyachi, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 118(6), 1073-1079, Jun. 2002

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• Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule, Y Hamazaki, M Itoh, H Sasaki, M Furuse, S Tsukita, JOURNAL OF BIOLOGICAL CHEMISTRY, 277(1), 455-461, Jan. 2002

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• Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions, M Itoh, H Sasaki, M Furuse, H Ozaki, T Kita, S Tsukita, JOURNAL OF CELL BIOLOGY, 154(3), 491-497, Aug. 2001

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• Multifunctional strands in tight junctions, S Tsukita, M Furuse, M Itoh, NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2(4), 285-293, Apr. 2001

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• Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2 and ZO-3, with the COOH termini of claudins, M Itoh, M Furuse, K Morita, K Kubota, M Saitou, S Tsukita, JOURNAL OF CELL BIOLOGY, 147(6), 1351-1363, Dec. 1999
• Structural and signalling molecules come together at tight junctions, S Tsukita, M Furuse, M Itoh, CURRENT OPINION IN CELL BIOLOGY, 11(5), 628-633, Oct. 1999
• Differential behavior of E-cadherin and occludin in their colocalization with ZO-1 during the establishment of epithelial cell polarity, Y Ando-Akatsuka, S Yonemura, M Itoh, M Furuse, S Tsukita, JOURNAL OF CELLULAR PHYSIOLOGY, 179(2), 115-125, May 1999

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• Functional domains of alpha-catenin required for the strong state of cadherin-based cell adhesion, Y Imamura, M Itoh, Y Maeno, S Tsukita, A Nagafuchi, JOURNAL OF CELL BIOLOGY, 144(6), 1311-1322, Mar. 1999
• Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin, M Itoh, K Morita, S Tsukita, JOURNAL OF BIOLOGICAL CHEMISTRY, 274(9), 5981-5986, Feb. 1999
• Normal development of mice and unimpaired cell adhesion cell motility actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout, Y Doi, M Itoh, S Yonemura, S Ishihara, H Takano, T Noda, S Tsukita, S Tsukita, JOURNAL OF BIOLOGICAL CHEMISTRY, 274(4), 2315-2321, Jan. 1999
• Subcellular distribution of tight junction-associated proteins (occludin, ZO-1, ZO-2) in rodent skin, K Morita, M Itoh, M Saitou, Y Ando-Akatsuka, M Furuse, K Yoneda, S Imamura, K Fujimoto, S Tsukita, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 110(6), 862-866, Jun. 1998

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• Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions, M Saitou, K Fujimoto, Y Doi, M Itoh, T Fujimoto, M Furuse, H Takano, T Noda, S Tsukita, JOURNAL OF CELL BIOLOGY, 141(2), 397-408, Apr. 1998
• Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction, K Mandai, H Nakanishi, A Satoh, H Obaishi, M Wada, H Nishioka, M Itoh, A Mizoguchi, T Aoki, T Fujimoto, Y Matsuda, S Tsukita, Y Takai, JOURNAL OF CELL BIOLOGY, 139(2), 517-528, Oct. 1997
• Mammalian occludin in epithelial cells: Its expression and subcellular distribution, M Saitou, Y AndoAkatsuka, M Itoh, M Furuse, J Inazawa, K Fujimoto, S Tsukita, EUROPEAN JOURNAL OF CELL BIOLOGY, 73(3), 222-231, Jul. 1997
• Occludin as a possible determinant of tight junction permeability in endothelial cells, T Hirase, JM Staddon, M Saitou, Y AndoAkatsuka, M Itoh, M Furuse, K Fujimoto, S Tsukita, LL Rubin, JOURNAL OF CELL SCIENCE, 110, 1603-1613, Jul. 1997
• Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to or catenin and actin filaments, M Itoh, A Nagafuchi, S Moroi, S Tsukita, JOURNAL OF CELL BIOLOGY, 138(1), 181-192, Jul. 1997
• Molecular architecture of tight junctions: Occludin and ZO-1, S Tsukita, M Furuse, M Itoh, CYTOSKELETAL REGULATION OF MEMBRANE FUNCTION, 52, 69-76, 1997
• Molecular dissection of tight junctions, S Tsukita, M Furuse, M Itoh, CELL STRUCTURE AND FUNCTION, 21(5), 381-385, Oct. 1996
• Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues, Y AndoAkatsuka, M Saitou, T Hirase, M Kishi, A Sakakibara, M Itoh, S Yonemura, M Furuse, S Tsukita, JOURNAL OF CELL BIOLOGY, 133(1), 43-47, Apr. 1996
• CELL-TO-CELL ADHERENS JUNCTION FORMATION AND ACTIN FILAMENT ORGANIZATION - SIMILARITIES AND DIFFERENCES BETWEEN NON-POLARIZED FIBROBLASTS AND POLARIZED EPITHELIAL-CELLS, S YONEMURA, M ITOH, A NAGAFUCHI, S TSUKITA, JOURNAL OF CELL SCIENCE, 108, 127-142, Jan. 1995
• DIRECT ASSOCIATION OF OCCLUDIN WITH ZO-1 AND ITS POSSIBLE INVOLVEMENT IN THE LOCALIZATION OF OCCLUDIN AT TIGHT JUNCTIONS, M FURUSE, M ITOH, T HIRASE, A NAGAFUCHI, S YONEMURA, S TSUKITA, S TSUKITA, JOURNAL OF CELL BIOLOGY, 127(6), 1617-1626, Dec. 1994
• AUTOIMMUNE MYOCARDITIS INDUCED IN MICE BY CARDIAC C-PROTEIN - CLONING OF COMPLEMENTARY-DNA ENCODING MURINE CARDIAC C-PROTEIN AND PARTIAL CHARACTERIZATION OF THE ANTIGENIC PEPTIDES, H KASAHARA, M ITOH, T SUGIYAMA, N KIDO, H HAYASHI, H SAITO, S TSUKITA, N KATO, JOURNAL OF CLINICAL INVESTIGATION, 94(3), 1026-1036, Sep. 1994

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• SUBMEMBRANOUS JUNCTIONAL PLAQUE PROTEINS INCLUDE POTENTIAL TUMOR-SUPPRESSOR MOLECULES, S TSUKITA, M ITOH, A NAGAFUCHI, S YONEMURA, S TSUKITA, JOURNAL OF CELL BIOLOGY, 123(5), 1049-1053, Dec. 1993
• OCCLUDIN - A NOVEL INTEGRAL MEMBRANE-PROTEIN LOCALIZING AT TIGHT JUNCTIONS, M FURUSE, T HIRASE, M ITOH, A NAGAFUCHI, S YONEMURA, S TSUKITA, S TSUKITA, JOURNAL OF CELL BIOLOGY, 123(6), 1777-1788, Dec. 1993
• THE 220-KD PROTEIN COLOCALIZING WITH CADHERINS IN NONEPITHELIAL CELLS IS IDENTICAL TO ZO-1, A TIGHT JUNCTION ASSOCIATED PROTEIN IN EPITHELIAL-CELLS - CDNA CLONING AND IMMUNOELECTRON MICROSCOPY, M ITOH, A NAGAFUCHI, S YONEMURA, T KITANIYASUDA, S TSUKITA, S TSUKITA, JOURNAL OF CELL BIOLOGY, 121(3), 491-502, May 1993
• A 220-KD UNDERCOAT-CONSTITUTIVE PROTEIN - ITS SPECIFIC LOCALIZATION AT CADHERIN-BASED CELL CELL-ADHESION SITES, M ITOH, S YONEMURA, A NAGAFUCHI, S TSUKITA, S TSUKITA, JOURNAL OF CELL BIOLOGY, 115(5), 1449-1462, Dec. 1991
• A NEW 400-KD PROTEIN FROM ISOLATED ADHERENS JUNCTIONS - ITS LOCALIZATION AT THE UNDERCOAT OF ADHERENS JUNCTIONS AND AT MICROFILAMENT BUNDLES SUCH AS STRESS FIBERS AND CIRCUMFERENTIAL BUNDLES, S TSUKITA, M ITOH, S TSUKITA, JOURNAL OF CELL BIOLOGY, 109(6), 2905-2915, Dec. 1989
• Molecular alterations associated with pathophysiology in liver-specific ZO-1 and ZO-2 knockout mice., Itoh Masahiko;Watanabe Kenji;Mizukami Yoichi;Sugimoto Hiroyuki, Cell structure and function, 49(2), 83-99, 26 Sep. 2024

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MISC

• MUPP1, a homologue of Drosophila Discs Lost (DLT), interacts with nectin, an immunoglobulin-like membrane protein, Y Hamazaki, Y Kobayashi, M Itoh, M Furuse, S Tsukita, MOLECULAR BIOLOGY OF THE CELL, 13, 494A-494A, Nov. 2002
• Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions, M Itoh, H Sasaki, M Furuse, H Ozaki, T Kita, S Tsukita, MOLECULAR BIOLOGY OF THE CELL, 12, 219A-219A, Nov. 2001
• Identification and characterization of MUPP1 containing 13 PDZ domains as a claudin-1-binding partner, Y Hamazaki, M Itoh, H Sasaki, M Furuse, S Tsukita, MOLECULAR BIOLOGY OF THE CELL, 12, 220A-220A, Nov. 2001
• Subcellular distribution of thigh junction-associated proteins, occludin, ZO-1 and ZO-2 in rodent skin and its development changes, K Morita, M Itoh, M Saitou, Y Ando-Akatsuka, M Furuse, K Yoneda, S Imamura, K Fujimoto, S Tsukita, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 110(4), 542-542, Apr. 1998
• Afadin: A novel actin filament-binding protein in with one PDZ domain localized at cadherin-based cell-to-cell adherens junction (vol 139, pg 517, 1997), K Mandai, H Nakanishi, A Satoh, H Obaishi, M Wada, H Nishioka, M Itoh, A Mizoguchi, T Aoki, T Fujimoto, Y Matsuda, S Tsukita, Y Takai, JOURNAL OF CELL BIOLOGY, 139(4), 1061-1061, Nov. 1997
• Molecular dissection of two tight junction-associated maguk family members, ZO-1 and ZO-2., M Itoh, K Morita, S Tsukita, MOLECULAR BIOLOGY OF THE CELL, 7, 3528-3528, Dec. 1996
• Distinct domains of alpha catenin, required for cadherin activation and cytoskeleton interaction, synergistically support the strong cell adhesion state., A Nagafuchi, M Itoh, S Ishihara, Y Imamura, S Tsukita, MOLECULAR BIOLOGY OF THE CELL, 7, 2658-2658, Dec. 1996
• Molecular dissection of tight junctions: Occludin, ZO-1, and ZO-2., S Tsukita, M Furuse, M Itoh, MOLECULAR BIOLOGY OF THE CELL, 7, 956-956, Dec. 1996
• Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo, Y AndoAkatsuka, M Saitou, T Hirase, M Kishi, A Sakakibara, M Itoh, S Yonemura, M Furuse, S Tsukita, MOLECULAR BIOLOGY OF THE CELL, 7, 3525-3525, Dec. 1996

Books etc

• Introduction to the Blood-Brain Barrier, Contributor, Tsukita S, Furuse M, Itoh M, Molecular dissection of tight junctions: occludin and ZO-1, Cambridge University Press, 1998, Not refereed

Presentations

• The Small-G Protein Rap1 Regulates Breast Acinar Polarity in Human Epithelial Cells, Itoh M, Myers C, Bissell MJ, American Society for Cell Biology 45th Annual Meeting, 2005, Nominated symposium, True
• Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins, Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S, Batsheva Seminar: The Dialogue between Cell Adhesion, Protein Degradation and Transcriptional Regulation, 1999, Poster presentation, True
• Molecular dissection of tight junctions, Tsukita S, Furuse M, Itoh M, US-Japan Cooperative Cancer Research Program, 1998, Invited oral presentation, True
• Occludin: A novel tight junction integral membrane protein, Tsukita S, Furuse M, Itoh M, The 9th International Congress of the International Society of Differentiation, 1996, Invited oral presentation, True