KAI NOBUYUKI

Profiles

Profiles

• 氏名

  KAI NOBUYUKI

Affiliation

• Assistant Professor

Profile and Settings

Affiliation

• Dokkyo Medical University, Division for Memory and Cognitive Function, Research Center for Advanced Medical Science, Comprehensive Research Facilities for Advanced Medical Science, Assistant Professor, Assistant prof lv

Degree

• Doctor of Philosophy, The Graduate University for Advanced Studies

Research Interests

• Neuroethology
• 快情動
• 記憶
• 社会的動機づけ
• 海馬
• 側坐核
• 腹側被蓋野
• ドーパミン
• モノアミン

Research Areas

• Life Science, Basic brain sciences
• Life Science, Cognitive and brain science
• Life Science, Neuroscience-general, Neuroethology

Research Experience

• Sep. 2021, 9999, Dokkyo Medical University, Division for Memory and Cognitive Function, Research Center for Advanced Medical Science, Comprehensive Research Facilities for Advanced Medical Science, Assistant Professor
• Apr. 2021, 9999, Dokkyo Medical University, Division for Memory and Cognitive Function, Research Center for Advanced Medical Science, Comprehensive Research Facilities for Advanced Medical Science, Assistant Professor
• Jun. 2013, Mar. 2021, Dokkyou Medical University, Dept. of Histology and neurobiology, assistant professor
• Apr. 2004, May 2013, Dept. of Molecular Genetics, Fukushima Medical University, Assistant Professor
• Apr. 2002, Mar. 2004, Dept. of Ultrastrucutual Research, National Center of Neurology and Psychiatry, Research Fellow
• Apr. 1997, Mar. 2002, Lab. for Neurobiology of Emotion, Brain Science Institute, The Institute of Physical and Chemical Research, Research Fellow
• Oct. 1996, Mar. 1997, lab. of Neurobiology and Behavioral Genetics, Institute for Physiological Sciences, Visiting Fellow

Association Memberships

• Jan. 2008, 9999, Society for Neuroscience
• Apr. 1998, 9999, 日本神経科学会

Research achievements

Published Papers

Original paper
• Multipoint MicroLED probes for selective neural stimulation in optogenetics, Ayumu Okui; Kazuki Moriya; Nobuyuki Kai; Mitsuhiro Yamada; Atsushi Nishikawa; Alexander Loesing; Noriaki Ohkawa; Hiroto SEKIGUCHI, Japanese Journal of Applied Physics, 64(048005), 1-5, 02 Apr. 2025

  DOI
• Induction of aberrant agonistic behavior by a combination of serotonergic and dopaminergic manipulation in rats, Nobuyuki Kai; Shuichi Ueda, Brain Structure and Function, 226(4), 1253-1267, May 2021

  DOI
• Differential roles of dopamine D1 and D2 receptor-containing neurons of the nucleus accumbens shell in behavioral sensitization, Nobuyuki Kai; Kayo Nishizawa; Yuji Tsutsui; Shuichi Ueda; Kazuto Kobayashi, JOURNAL OF NEUROCHEMISTRY, 135(6), 1232-1241, Dec. 2015

  DOI
• Enhanced flexibility of place discrimination learning by targeting striatal cholinergic interneurons, Kana Okada; Kayo Nishizawa; Ryoji Fukabori; Nobuyuki Kai; Akira Shiota; Masatsugu Ueda; Yuji Tsutsui; Shogo Sakata; Natsuki Matsushita; Kazuto Kobayashi, NATURE COMMUNICATIONS, 5, 3778, May 2014

  DOI
• Lesions of the nucleus accumbens core modulate development of matching behavior, Nobuyuki Kai; Yuji Tsutsui; Kazuto Kobayashi, BMC NEUROSCIENCE, 15, 55, Apr. 2014

  DOI
• Striatal Indirect Pathway Contributes to Selection Accuracy of Learned Motor Actions, Kayo Nishizawa; Ryoji Fukabori; Kana Okada; Nobuyuki Kai; Motokazu Uchigashima; Masahiko Watanabe; Akira Shiota; Masatsugu Ueda; Yuji Tsutsui; Kazuto Kobayashi, JOURNAL OF NEUROSCIENCE, 32(39), 13421-13432, Sep. 2012

  DOI
• Striatal direct pathway modulates response time in execution of visual discrimination, Ryoji Fukabori; Kana Okada; Kayo Nishizawa; Nobuyuki Kai; Kenta Kobayashi; Motokazu Uchigashima; Masahiko Watanabe; Yuji Tsutsui; Kazuto Kobayashi, EUROPEAN JOURNAL OF NEUROSCIENCE, 35(5), 784-797, Mar. 2012

  DOI
• Up-regulation of dopamine D-1 receptor in the hippocampus after establishment of conditioned place preference by cocaine, Tomoko Tanaka; Nobuyuki Kai; Kazuto Kobayashi; Yuji Takano; Naoyuki Hironaka, NEUROPHARMACOLOGY, 61(4), 842-848, Sep. 2011

  DOI
• Lever pressing responses under a fixed-ratio schedule of mice with 6-hydroxydopamine-induced dopamine depletion in the nucleus accumbens, Yuji Tsutsui; Kayo Nishizawa; Nobuyuki Kai; Kazuto Kobayashi, BEHAVIOURAL BRAIN RESEARCH, 217(1), 60-66, Feb. 2011

  DOI
• Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord, Tomoyuki Masuda; Nobuyuki Kai; Chie Sakuma; Kazuto Kobayashi; Hisashi Koga; Hiroyuki Yaginuma, BRAIN RESEARCH, 1249, 61-67, Jan. 2009

  DOI
• Transient silencing of synaptic transmitter release from specific neuronal types by recombinant tetanus toxin light chain fused to antibody variable region, Tomoko Kobayashi; Nobuyuki Kai; Kenta Kobayashi; Tomonori Fujiwara; Kimio Akagawa; Masanori Onda; Kazuto Kobayashi, JOURNAL OF NEUROSCIENCE METHODS, 175(1), 125-132, Oct. 2008

  DOI
• Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography, Shigeto Sato; Tomoki Chiba; Shingo Nishiyama; Takeharu Kakiuchi; Hideo Tsukada; Taku Hatano; Takahiro Fukuda; Yasunobu Yasoshima; Nobuyuki Kai; Kazuto Kobayashi; Yoshikuni Mizuno; Keiji Tanaka; Nobutaka Hattori, JOURNAL OF NEUROSCIENCE RESEARCH, 84(6), 1350-1357, Nov. 2006

  DOI
• Altered gene expression in the subdivisions of the amygdala of Fyn-deficient mice as revealed by laser capture microdissection and mKIAA cDNA array analysis, N Kai; K Iwase; K Imai; E Nakahira; M Soma; S Ohtsuka; T Yagi; K Kobayashi; H Koga; M Takiguchi; S Yuasa, BRAIN RESEARCH, 1073(1), 60-70, Feb. 2006

  DOI
• Subthalamic neurons coordinate basal ganglia function through differential neural pathways, Y Yasoshima; N Kai; S Yoshida; S Shiosaka; Y Koyama; Y Kayama; K Kobayashi, JOURNAL OF NEUROSCIENCE, 25(34), 7743-7753, Aug. 2005

  DOI
• Aberrant responses to acoustic stimuli in mice deficient for neural recognition molecule NB-2, H Li; Y Takeda; H Niki; J Ogawa; S Kobayashi; N Kai; K Akasaka; M Asano; K Sudo; Y Iwakura; K Watanabe, EUROPEAN JOURNAL OF NEUROSCIENCE, 17(5), 929-936, Mar. 2003

  DOI
• Altered tone-induced Fos expression in the mouse inferior colliculus after early exposure to intense noise, N Kai; H Niki, NEUROSCIENCE RESEARCH, 44(3), 305-313, Nov. 2002

  DOI
• Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex, N Kohmura; K Senzaki; S Hamada; N Kai; R Yasuda; M Watanabe; H Ishii; M Yasuda; M Mishina; T Yagi, NEURON, 20(6), 1137-1151, Jun. 1998

  DOI
• Molecular cloning of Fyn-associated molecules in the mouse central nervous system, N Kai; M Mishina; T Yagi, JOURNAL OF NEUROSCIENCE RESEARCH, 48(5), 407-424, Jun. 1997
• STABLE PRODUCTION OF MUTANT MICE FROM DOUBLE GENE CONVERTED ES CELLS WITH PUROMYCIN AND NEOMYCIN, S WATANABE; N KAI; M YASUDA; N KOHMURA; M SANBO; M MISHINA; T YAGI, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 213(1), 130-137, Aug. 1995

  DOI
• HUMAN HIGH-AFFINITY FC-GAMMA-RI (CD64) GENE MAPPED TO CHROMOSOME 1Q21.2-Q21.3 BY FLUORESCENCE IN-SITU HYBRIDIZATION, S TAKAI; M KASAMA; K YAMADA; N KAI; N HIRAYAMA; H NAMIKI; T TANIYAMA, HUMAN GENETICS, 93(1), 13-15, Jan. 1994

MISC

• 基底核と行動選択, 甲斐信行; 小林和人, Clinical Neuroscience, 29(7), 2011
• Animal models for the study of instrumental learning and behavioral control, 小林 和人; 深堀 良二; 甲斐 信行, 生体の科学, 61(1), 47-52, Jan. 2010
• P1-23 マウスの側坐核ニューロンの破壊がメタンフェタミン投与による条件性場所選好および逆耐性現象に及ぼす影響(日本動物心理学会第68回大会発表要旨), 西澤 佳代; 甲斐 信行; 小林 和人; 筒井 雄二, 動物心理学研究, 58(2), 197-197, 25 Dec. 2008
• 基底核と記憶--Basal ganglia and memory (特集 大脳基底核と情動) -- (基底核と高次機能), 甲斐 信行; 小林 和人, 分子精神医学, 8(4), 294-299, Oct. 2008
• Dopaminergic regulation of behavior and its development, 甲斐 信行; 小林 和人, 蛋白質核酸酵素, 53(4), 565-572, Mar. 2008
• P-42 6-OHDAの側坐核投与がマウスのレバー押し行動,オープンフィールド活動性および摂食行動に及ぼす影響(日本動物心理学会第67回大会発表要旨), 西澤 佳代; 甲斐 信行; 小林 和人; 筒井 雄二, 動物心理学研究, 57(2), 152-152, 25 Dec. 2007
• Molecular mechanisms underlying emotional memory, 湯浅茂樹; 甲斐信行; 甲斐信行; 相馬美歩, 神経研究の進歩, 50(1), 2006
• マウス精子形成過程におけるFynチロシンキナーゼの機能解析, 前川真見子; 湯浅茂樹; 安田昌弘; 八木健; 甲斐信行, 生理学研究所年報, 20, 1999
• Knockout Mouse Data Book. Agrin., 甲斐信行, Molecular Medicine, 34(Dec), 1997
• Knockout Mouse Data Book. MuSK(muscle-specific kinase)., 甲斐信行, Molecular Medicine, 34(Dec), 1997
• Living and death of nerve cells. Birth of nerve cells. Heredity of cerebral functions., 八木健; 甲斐信行; 安田昌弘, 現代化学増刊, 32, 1997
• Behavioral genetics by gene targeting., 八木健; 安田昌弘; 甲斐信行, 実験医学, 12(19), 1994

Books etc

• Functional circuitry analysis in rodents using neurotoxins/immunotoxins., Joint work, Kobayashi, K; Okada, K; Kai, N, Humana Press Inc., 2012, Not refereed

Presentations

• Lesions of the Nucleus Accumbens Core Modulate Development of Matching Behavior., Kai N., 13 Oct. 2015, Invited oral presentation, Japanese Alcohol, Nicotine & Drug Addiction Conference 2015, Kobe, False
• The development of operant matching is regulated by the Nucleus Accumbens core, Kai N., Nov. 2011, Poster presentation, The Society for Neuroscience annual meeting, True
• Conditional ablation of dopamine D2 receptor-containing neurons in the nucleus accumbens shell impairs reward-related behavior., Kai N., Nov. 2008, Poster presentation, The Society for Neuroscience annual meeting, True
• Differential roles of dopamine D1 and D2 receptor-containing neurons of the nucleus accumbens shell in behavioral sensitization., Kai N., Sep. 2015, Oral presentation, The 58th Annual Meeting of Japanese Society for Neurochemistry, False
• The development of operant matching is regulated by the Nucleus Accumbens core, Kai N., Sep. 2011, Poster presentation, The 34th Annual Meeting of Japan Neuroscience Society, False
• Roles of two types of dopamine receptor-containing neurons of nucleus accumbens shell in reward-related behavior., Kai N., 2008, Poster presentation, The 31th Annual Meeting of Japan Neuroscience Society, False
• The role of dopamine D2 receptor-expressing neurons in the nucleus accumbens core in operant matching., Kai N., 2008, Poster presentation, The 33rd Annual Meeting of Japan Neuroscience Society, False
• Conditional ablation of dopamine D2 receptor-containing neurons in the nucleus accumbens shell impairs reward-related behavior., Kai N., 2007, Poster presentation, The 30th Annual Meeting of the Molecular Biology Society of Japan, False
• Conditional ablation of dopamine D2 receptor containing cells in the nucleus accumbens., Kai N., 2005, Poster presentation, The 28th Annual Meeting of Japan Neuroscience Society, False
• cDNA array analysis of gene expression profiles in the amygdala subdivisions of hetero- and homo- Fyn deficient mice following NMDA administration., Kai N., 2004, Oral presentation, The 27th Annual Meeting of Japan Neuroscience Society, False
• Comprehensive analysis of gene expression in a single neuron from mouse amygdala., Kai N., 2003, Poster presentation, The 26th Annual Meeting of Japan Neuroscience Society, False
• Increase in autophosphorylation of Ca2+/calmpdulin-dependent protein kinase II in the inferior colliculus after early noise exposure (priming)., Kai N., 2001, Poster presentation, The 24th Annual Meeting of the Molecular Biology Society of Japan, False
• Enhanced reactivity to tone in Inferior Colliculus following early noise exposure (priming)., Kai N., 2000, Poster presentation, The 23rd Annual Meeting of Japan Neuroscience Society, False
• Induction of aberrant agonistic behavior by a combination of serotonergic and dopaminergic manipulation in rats., Nobuyuki Kai, The 44th Annual meeting of the Japan Neuroscience Society, 28 Jul. 2021, Poster presentation
• モノアミン神経操作誘発性の社会行動異常に関わる脳部位の解析, 甲斐信行, 第124回日本解剖学会総会・全国学術集会, 25 Mar. 2019
• Ethological and histological analysis of intra-specific defensive rage induced by monoaminergic manipulation., Nobuyuki Kai, The 41st Annual Meeting of Japan Neuroscience Society, Jul. 2018
• Analysis of abnormal social behaviors caused by manipulations of monoaminergic neurotransmissions., Nobuyuki Kai, The 123rd Annual Meeting of The Japanese Association of Anatomists, Mar. 2018
• Analysis of abnormal behaviors and neuronal activities caused by manipulations of monoaminergic neurotransmissions., Nobuyuki Kai, The 122nd Annual Meeting of The Japanese Association of Anatomists, Mar. 2017
• 側坐核コアの破壊が対応法則に従った行動の獲得に及ぼす影響, 甲斐信行, 平成27年度アルコール薬物依存関連学会合同学術集会・シンポジウム：嗜癖・依存と意思決定, 13 Oct. 2015, Nominated symposium
• Differential roles of dopamine D1 and D2 receptor-containing neurons of the nucleus accumbens shell in behavioral sensitization., Nobuyuki Kai, The 58th Annual Meeting of Japanese Society for Neurochemistry, Sep. 2015
• The development of operant matching is regulated by the Nucleus Accumbens core., Nobuyuki Kai, The Society for Neuroscience annual meeting, Nov. 2011
• The development of operant matching is regulated by the Nucleus Accumbens core., Nobuyuki Kai, The 34th Annual Meeting of Japan Neuroscience Society, Jul. 2011
• The role of dopamine D2 receptor-expressing neurons in the nucleus accumbens core in operant matching., Nobuyuki Kai, The 33rd Annual Meeting of Japan Neuroscience Society, Jul. 2010
• Conditional ablation of dopamine D2 receptor-containing neurons in the nucleus accumbens shell impairs reward-related behavior., Nobuyuki Kai, The Society for Neuroscience annual meeting, Nov. 2008
• 報酬行動における2種類の側坐核shell投射ニューロンの役割, 第31回日本神経科学大会, 2008, Poster presentation
• Roles of two types of dopamine receptor-containing neurons of nucleus accumbens shell in reward-related behavior, The 31st Annual Meeting of the Japan Neuroscience Society, 2008, Poster presentation
• 側坐核shellにおけるドーパミンD2受容体陽性細胞の選択的除去が報酬行動に及ぼす役割の検討, 第30回日本分子生物学会年会, 2007, Poster presentation
• Conditional ablation of dopamine D2receptor-containing neurons in the nucleus accumbens shell impairs reward-related behavior, The 30th Annual Meeting of the Molecular Biology Society of Japan, 2007, Poster presentation
• Conditional ablation of dopamine D2 receptor containing cells in the nucleus accumbens., Nobuyuki Kai, The 28th Annual Meeting of Japan Neuroscience Society, Jul. 2005
• cDNA array analysis of gene expression profiles in the amygdala subdivisions of hetero- and homo- Fyn deficient mice following NMDA administration., Nobuyuki Kai, The 27th Annual Meeting of Japan Neuroscience Society, Jul. 2004
• Comprehensive analysis of gene expression in a single neuron from mouse amygdala, Nobuyuki Kai, The 26th Annual Meeting of Japan Neuroscience Society, Jul. 2003
• Increase in autophosphorylation of Ca2+/calmpdulin-dependent protein kinase II in the inferior colliculus after early noise exposure (priming), Nobuyuki Kai, The 24th Annual Meeting of the Molecular Biology Society of Japan, Jul. 2001
• Enhanced reactivity to tone in Inferior Colliculus following early noise exposure (priming), Nobuyuki Kai, The 23rd Annual Meeting of Japan Neuroscience Society, Jul. 2000

学内助成金

• 2006, 2006, 400000

Educational activity

Teaching Experience

• 99 Oct. 2022, Practical training of biochemistry, Dokkyo Medical University